Hereditary Cancer and Genetic Testing

Genes linked to hereditary cancers

Inherited mutations have been linked to many different types of mutations. Some types of cancer are more likely to be hereditary. Below is a list of common cancers, and the most common genes that have been linked to increased risk for each.

Cancer Genes
Breast cancer in women

ATMBARD1BRCA1BRCA2, BRIP1*, CHEK2,  CDH1, NF1NBNPALB2PTEN, RAD51C*, RAD51D*, STK11TP53

Breast cancer in men

BRCA1BRCA2CHEK2PALB2

Colorectal cancer

EPCAMMLH1MSH2MSH6PMS2CHEK2PTENSTK11TP53, MUTYH  

Endometrial cancer

EPCAMMLH1MSH2MSH6PMS2PTENSTK11

Fallopian tube, ovarian, primary peritoneal cancer

ATM*, BRCA1BRCA2BRIP1EPCAMMLH1,  MSH2,  MSH6NBN*, PALB2RAD51C, RAD51D, STK11**

Gastric cancer

CDH1STK11, EPCAMMLH1,  MSH2MSH6PMS2*

Melanoma

BAP1 (especially uveal melanoma), BRCA2 CDK4CDKN2APTENTP53

Pancreatic cancer

ATMBRCA1BRCA2CDKN2AEPCAM*, MLH1,  MSH2*, MSH6,* PALB2STK11TP53

Prostate cancer

ATMBRCA1BRCA2CHEK2EPCAM*, MLH1*, MSH2*, MSH6*, PALB2PMS2*

* More research is needed to confirm a link between this cancer type and an inherited mutation in this gene.

** Most ovarian tumors in people with this mutation are benign.

Last updated September 13, 2020