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BRIP1: Cancer Risk
People with an inherited mutation in the BRIP1 gene have an increased risk for certain types of cancer. Learn about the cancer risks associated with BRIP1 mutations.

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Cancer Risk Associated with Inherited Mutations

If you have tested positive for a mutation, we recommend you speak with a genetics expert who can look at your personal and family history of cancer and can help you decide on a plan for managing your cancer risk. 

, ovarian and primary peritoneal cancer risks

People with a mutation have a 5-15% lifetime risk of , ovarian or primary peritoneal cancer. These three cancers are related and are often referred to together as ovarian cancer.

Other cancer risks for people with a mutation

There is not yet enough research to conclude that a mutation is associated with an increased risk of other adult-onset cancers. Research on the risk for cancer in people with mutations is ongoing. 

It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years will vary depending on:

  • current age
  • sex assigned at birth
  • specific mutation
  • personal and family health history
  • diet, exercise, lifestyle and other factors

Risk Graph

Graph of lifetime risk for women with a BRIP1 mutation

Last updated June 21, 2024