Hereditary Cancer and Genetic Testing

Cancer risk associated with inherited BRIP1 mutations

If you have tested positive for a BRIP1 mutation, we recommend consulting with a genetics expert who can assess your personal and family history of cancer and can help you determine the best risk management plan.

Risks for women with a BRIP1 mutation

  • About a 10% lifetime risk of ovarian cancer.
  • A potentially increased lifetime risk for breast cancer, specifically triple-negative breast cancer.

Other cancer risks for people with a BRIP1 mutation

Currently, evidence is insufficient to conclusively show that a BRIP1 mutation is associated with an increased risk of other adult-onset cancers. Research on the risk for cancer in people with BRIP1 mutations is ongoing. 

Graph of lifetime risk for women with a <abbr
                class='glossary-tip tt-brip1'
                title='<p>BRIP1 is a gene found on chromosome 17.&nbsp;Women who inherit one mutated copy of BRIP1 are at an increased risk of&nbsp;ovarian cancer.&nbsp;Research on the risk for other cancers for people with a mutation&nbsp;in BRIP1 is ongoing.</p>

<p>Inheriting two mutated copies of BRIP1, one from each parent, causes a rare blood disease known as Fanconi anemia in children.</p>
            >BRIP1</abbr> mutation

  • NCT02665195: Prospective Registry Of MultiPlex Testing (PROMPT). PROMPT is an online research registry. The goal of PROMPT is to help researchers to better understand the risks that are linked to mutations in less well-studied genes. People with BRIP1 mutations can enroll in PROMPT to help researchers learn more about cancer risks. 
Last updated September 02, 2021