BRIP1 Gene Mutations: Cancer Risk

If you have tested positive for a BRIP1 mutation, we recommend you speak with a genetics expert who can look at your personal and family history of cancer and can help you decide on a plan for managing your cancer risk. 

Experts at the National Comprehensive Cancer Network (NCCN) created guidelines which estimate the cancer risks for people with BRIP1 mutations. These cancer risk estimates are updated based on the latest research.

It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years may vary depending on:

• current age.
• sex assigned at birth.
• specific type and location of mutation on the BRIP1 gene. 
• personal and family health history.
• diet, exercise, lifestyle and other factors.

The information below is based on the 2027 guidelines.

Fallopian tube, ovarian and primary peritoneal cancer risks

People with a BRIP1 mutation have a 5-15% lifetime risk of fallopian tube, ovarian or primary peritoneal cancer. These three cancers are related and are often referred to together as ovarian cancer. According to the National Cancer Institute, the average lifetime risk for these cancers in people without a mutation is about 1.1%.

Other cancer risks for people with a BRIP1 mutation

There is not yet enough research to conclude that a BRIP1 mutation is associated with an increased risk of other cancers. Because questions about cancer risk remain unanswered, genetics experts often use a family's history of cancer and other risk factors to help people with BRIP1 mutations better understand their cancer risks and make informed decisions about their care.

Participate in Research