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Treatment for Metastatic Castration-Sensitive Prostate Cancer and Inherited or Tumor Mutations in DNA Damage Repair Genes (Amplitude)

Treatment for Metastatic Castration-Sensitive Prostate Cancer and Inherited or Tumor Mutations in DNA Damage Repair Genes (Amplitude)

Clinicaltrials.gov identifier:
NCT04497844

Treatment
Treatment for metastatic castration-sensitive prostate cancer and a tumor or inherited mutation in BRCA1, BRCA2, ATM, BRIP1, CHEK2, PALB2 or related gene

Differences in Family Communication about Positive Genetic Test Results Between Indian, Chinese, and Filipino Americans

Differences in Family Communication about Positive Genetic Test Results Between Indian, Chinese, and Filipino Americans

Surveys, Registries, Interviews
Interview for Indian, Chinese or Filipino Americans with a mutation in BRCA1, BRCA2, ATM, CHEK2, PALB2 or other gene linked to breast or ovarian cancer risk

Combination Drugs for Treating Metastatic Castration-resistant Prostate Cancer with Tumor Mutation the Affect DNA Repair

Combination Drugs for Treating Metastatic Castration-resistant Prostate Cancer with Tumor Mutation the Affect DNA Repair

Clinicaltrials.gov identifier:
NCT03012321

Treatment
Treatment study for men with metastatic castration-resistant prostate cancer

PARP inhibitor (niraparib) in patients with inherited or tumor PALB2 mutations in advanced solid tumors (PAVO)

PARP inhibitor (niraparib) in patients with inherited or tumor PALB2 mutations in advanced solid tumors (PAVO)

Clinicaltrials.gov identifier:
NCT05169437

Treatment
Any advanced or metastatic solid tumor except ovarian or prostate

NUV-868 Alone and in Combination With PARP Inhibitors in Patients With Advanced Solid Tumors

NUV-868 Alone and in Combination With PARP Inhibitors in Patients With Advanced Solid Tumors

Clinicaltrials.gov identifier:
NCT05252390

Treatment
Treatment study for people with advanced solid tumors, including triple-negative breast, ovarian, pancreatic and prostate cancer

Physical Activity Promotion for Breast and Endometrial Cancer Survivors

Physical Activity Promotion for Breast and Endometrial Cancer Survivors

Clinicaltrials.gov identifier:
NCT04262180

Quality of Life
Exercise study for breast or endometrial cancer survivors

Studying the Medication Olaparib Given with Radium-223 for Advanced Prostate Cancer with Bone Metastasis

Studying the Medication Olaparib Given with Radium-223 for Advanced Prostate Cancer with Bone Metastasis

Clinicaltrials.gov identifier:
NCT03317392

Treatment
People with castration-resistant prostate cancer with bone spread

Denosumab for Preventing Breast Cancer in Women with a BRCA1 Inherited Mutation (BRCA-P)

Denosumab for Preventing Breast Cancer in Women with a BRCA1 Inherited Mutation (BRCA-P)

Clinicaltrials.gov identifier:
NCT04711109

Prevention
Prevention study enrolling women ages 25-55 with a BRCA1 mutation

Abiraterone/Prednisone and Olaparib Alone or In Combination for Treatment of Metastatic Castration-Resistant Prostate Cancer With Mutations Related to DNA Repair

Abiraterone/Prednisone and Olaparib Alone or In Combination for Treatment of Metastatic Castration-Resistant Prostate Cancer With Mutations Related to DNA Repair

Clinicaltrials.gov identifier:
NCT03012321

Treatment
Men with mCRPC with an inherited mutation or a tumor mutation in a DNA damage repair gene

Research Opportunity for Previvors and their Romantic Partners

Research Opportunity for Previvors and their Romantic Partners

Surveys, Registries, Interviews
Interview for people with inherited mutations who had risk-reducing mastectomy and their partners

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Clinicaltrials.gov identifier:
NCT05129605

Prevention
People at high risk for prostate cancer due to an inherited mutation

Survey about Endometrial Cancer Risk and Risk-Reducing Surgery for Women with a BRCA1/2 Mutation or Mutation in the Family

Survey about Endometrial Cancer Risk and Risk-Reducing Surgery for Women with a BRCA1/2 Mutation or Mutation in the Family

Surveys, Registries, Interviews
Women with a BRCA mutation or from a family with a BRCA mutation

Young, Empowered & Strong: Web-Based Symptom Monitoring and Self-Management for Young Adult Breast Cancer Survivors

Young, Empowered & Strong: Web-Based Symptom Monitoring and Self-Management for Young Adult Breast Cancer Survivors

Clinicaltrials.gov identifier:
NCT04906200

Quality of Life
Women diagnosed with breast cancer between the ages of 15-39

Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women

Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women

Clinicaltrials.gov identifier:
NCT05287451

Prevention
Prevention study for women at high risk for ovarian cancer

Combination ATR inhibitor and PARP Inhibitor in Recurrent Ovarian Cancer (CAPRI)

Combination ATR inhibitor and PARP Inhibitor in Recurrent Ovarian Cancer (CAPRI)

Clinicaltrials.gov identifier:
NCT03462342

Treatment
Recurrent ovarian cancer

BRCA 1 and 2: Interviews on Genetic Testing and Individual Experiences

BRCA 1 and 2: Interviews on Genetic Testing and Individual Experiences

Surveys, Registries, Interviews
People with or without cancer who have had or are considering BRCA testing

UCLA Research Study: Zoom Interviews to Learn from Asian Americans Living with Metastatic Cancer

UCLA Research Study: Zoom Interviews to Learn from Asian Americans Living with Metastatic Cancer

Surveys, Registries, Interviews
Asian Americans with metastatic cancer of any type

A Study of Melphalan, BCNU, Vitamin B12b, Vitamin C, and Stem Cell Infusion in People with Advanced Pancreatic Cancer and BRCA Mutations

A Study of Melphalan, BCNU, Vitamin B12b, Vitamin C, and Stem Cell Infusion in People with Advanced Pancreatic Cancer and BRCA Mutations

Clinicaltrials.gov identifier:
NCT04150042

Treatment
Advanced pancreatic cancer in people with a BRCA1 or BRCA2 mutation

Metastatic Pancreatic Cancer in US

Metastatic Pancreatic Cancer in US

Surveys, Registries, Interviews
People with metastatic pancreatic cancer and their caregivers

Interviews for people with a genetic test result that was later reclassified

Interviews for people with a genetic test result that was later reclassified

Surveys, Registries, Interviews
People with a genetic test result that was later reclassified

Chemotherapy, Immunotherapy and PARP Inhibitor for the Treatment of Metastatic Aggressive Variant Prostate Cancer (AVPC)

Chemotherapy, Immunotherapy and PARP Inhibitor for the Treatment of Metastatic Aggressive Variant Prostate Cancer (AVPC)

Clinicaltrials.gov identifier:
NCT04592237

Treatment
Treatment in people with aggressive metastatic prostate cancer

All of Us Research Program

All of Us Research Program

Surveys, Registries, Interviews
Anyone age 18 or over

Studying Crowdfunding for Cancer

Studying Crowdfunding for Cancer

Surveys, Registries, Interviews
Cancer survivors who have used crowdfunding to help cover cancer-related costs

Treating Early-Stage BRCA, or PALB2-Associated Breast Cancer with a PARP Inhibitor (Niraparib) and Immunotherapy (Dostarlimab)

Treating Early-Stage BRCA, or PALB2-Associated Breast Cancer with a PARP Inhibitor (Niraparib) and Immunotherapy (Dostarlimab)

Clinicaltrials.gov identifier:
NCT04584255

Treatment
Early-stage breast cancer & a BRCA1, BRCA2 or PALB2 mutation

Interview Study: Exploring Gender Diverse Experiences of Hereditary Cancer Risk

Interview Study: Exploring Gender Diverse Experiences of Hereditary Cancer Risk

Surveys, Registries, Interviews
People with elevated cancer risk who identify as trans* or nonbinary

Investigational PARP Inhibitor AZD5305 Alone or Combined With Other Anti-cancer Agents in People With Advanced Solid Tumors (PETRA)

Investigational PARP Inhibitor AZD5305 Alone or Combined With Other Anti-cancer Agents in People With Advanced Solid Tumors (PETRA)

Clinicaltrials.gov identifier:
NCT04644068

Treatment
Advanced ovarian, breast, prostate or pancreatic cancer

Interview about Hispanic/Latino Community Experiences Accessing Genetic Testing for Hereditary Cancer Risk

Interview about Hispanic/Latino Community Experiences Accessing Genetic Testing for Hereditary Cancer Risk

Surveys, Registries, Interviews
Hispanic/Latino people with a personal diagnosis of cancer or a family history of cancer

ATR Inhibitor Plus Niraparib Study in Advanced Solid Tumors and Ovarian Cancer

ATR Inhibitor Plus Niraparib Study in Advanced Solid Tumors and Ovarian Cancer

Clinicaltrials.gov identifier:
NCT04267939

Treatment
Advanced ovarian cancer or other solid tumors

Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed

Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed

Clinicaltrials.gov identifier:
NCT03231891

Surveys, Registries, Interviews
People with an inherited mutation or cancer in the family

Adding Pembrolizumab to Olaparib to Treat Pancreatic Cancer in People with an Inherited BRCA Mutation

Adding Pembrolizumab to Olaparib to Treat Pancreatic Cancer in People with an Inherited BRCA Mutation

Clinicaltrials.gov identifier:
NCT04548752

Treatment
Metastatic pancreatic cancer and a BRCA1 or BRCA2 mutation

Tools To Be Fit: Tools to Improve Nutrition and Physical Activity for Colorectal Cancer Survivors

Tools To Be Fit: Tools to Improve Nutrition and Physical Activity for Colorectal Cancer Survivors

Clinicaltrials.gov identifier:
NCT05056077

Quality of Life
Nonmetastatic colon or rectal cancer

Testing  a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation

Testing a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation

Clinicaltrials.gov identifier:
NCT04367675

Prevention
People with a BRCA1 or BRCA2 mutation

Treatment with ATR Inhibitor for Advanced or Metastatic Solid Tumors

Treatment with ATR Inhibitor for Advanced or Metastatic Solid Tumors

Clinicaltrials.gov identifier:
NCT04657068

Treatment
Advanced solid tumors

Treating Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer with Chemotherapy and Rucaparib

Treating Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer with Chemotherapy and Rucaparib

Clinicaltrials.gov identifier:
NCT03337087

Treatment
Metastatic colorectal, pancreatic, gastroesophageal or biliary tract cancer

Nivolumab and Relatlimab in Advanced MSI-H Cancers Resistant to Prior PD-L1 Inhibitor

Nivolumab and Relatlimab in Advanced MSI-H Cancers Resistant to Prior PD-L1 Inhibitor

Clinicaltrials.gov identifier:
NCT03607890

Treatment
Solid tumors that are MSI-High and resistant to prior immunotherapy

Understanding the Experiences of Black Women after Cancer Genetic Testing

Understanding the Experiences of Black Women after Cancer Genetic Testing

Surveys, Registries, Interviews
Black women who have tested positive for an inherited mutation

Men at High Genetic Risk for Prostate Cancer

Men at High Genetic Risk for Prostate Cancer

Clinicaltrials.gov identifier:
NCT03805919

Prevention

Fear of Recurrence, Adversity, and Pain

Fear of Recurrence, Adversity, and Pain

Surveys, Registries, Interviews

Blood Markers of Early Pancreas Cancer

Blood Markers of Early Pancreas Cancer

Clinicaltrials.gov identifier:
NCT03568630

Prevention

COVID-19 Breast Cancer Care Survey

COVID-19 Breast Cancer Care Survey

Surveys, Registries, Interviews

Metastatic Prostate Cancer Project

Metastatic Prostate Cancer Project

Surveys, Registries, Interviews

The Metastatic Breast Cancer Project

The Metastatic Breast Cancer Project

Surveys, Registries, Interviews

Connect My Variant

Connect My Variant

Surveys, Registries, Interviews

Study for People with Unexpected Genetic Results

Study for People with Unexpected Genetic Results

Clinicaltrials.gov identifier:
NCT02595957

Prevention

ELLIE's Project

ELLIE's Project

Quality of Life

Find My Variant

Find My Variant

Surveys, Registries, Interviews

Pancreatic Cancer Early Detection

Pancreatic Cancer Early Detection

Clinicaltrials.gov identifier:
NCT02206360

Prevention

WISDOM Study

WISDOM Study

Clinicaltrials.gov identifier:
NCT02620852

Prevention

PROMPT

PROMPT

Clinicaltrials.gov identifier:
NCT02665195

Surveys, Registries, Interviews

Talazoparib Beyond BRCA (TBB) Trial

Talazoparib Beyond BRCA (TBB) Trial

Clinicaltrials.gov identifier:
NCT02401347

Treatment


Sponsored By:

Merck & Co., Inc.

This resource was made possible through an independent grant from Merck & Co., Inc.