Get notified of page updates
Research & Clinical Trials > Featured Research

Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. Sign up for our community newsletter to stay up to date on the latest hereditary cancer research.

How to Use Our Search and Enroll Tool

Featured Research

Study of a New InvestigationaI Inhibitor to Treat People with Advanced Solid Tumors

Study of a New InvestigationaI Inhibitor to Treat People with Advanced Solid Tumors

Clinicaltrials.gov identifier:
NCT05932862

Treatment
Treatment study for people with advanced solid tumors

NePtune: Using PARP Inhibitors Before Surgery in Localized Prostate Cancer

NePtune: Using PARP Inhibitors Before Surgery in Localized Prostate Cancer

Clinicaltrials.gov identifier:
NCT05498272

Treatment
Treatment study for people with intermediate- or high-risk prostate cancer with certain tumor mutations

Social Support and Coping Strategies Among LGBTQIA+ Cancer Patients

Social Support and Coping Strategies Among LGBTQIA+ Cancer Patients

Surveys, Registries, Interviews
This study explores how different levels of support systems influence coping strategies among LGBTQIA+ cancer patients

PROMISE Registry: A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness

PROMISE Registry: A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness

Clinicaltrials.gov identifier:
NCT04995198

Surveys, Registries, Interviews
A screening registry for people diagnosed with prostate cancer

Denosumab for Breast Cancer Risk Reduction in Women With an Inherited BRCA1 Mutation (The Breast Cancer Prevention Study)

Denosumab for Breast Cancer Risk Reduction in Women With an Inherited BRCA1 Mutation (The Breast Cancer Prevention Study)

Clinicaltrials.gov identifier:
NCT04711109

Prevention
Prevention study enrolling women ages 25-55 with a BRCA1 mutation

Olaparib with Cediranib or Ceralasertib for People with Advanced or Metastatic Breast Cancer and with a BRCA1 or BRCA2 Mutation

Olaparib with Cediranib or Ceralasertib for People with Advanced or Metastatic Breast Cancer and with a BRCA1 or BRCA2 Mutation

Clinicaltrials.gov identifier:
NCT04090567

Treatment
Treatment study for people with advanced breast cancer who have a BRCA1 or BRCA2 genetic mutation and who were previously treated with a PARP inhibitor

Pancreatic Cancer Screening Study (CAPS5)

Pancreatic Cancer Screening Study (CAPS5)

Clinicaltrials.gov identifier:
NCT02000089

Prevention
Screening study for people at high risk for pancreatic cancer

A Study to Compare Two Surgical Procedures in Women with BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer (SOROCk)

A Study to Compare Two Surgical Procedures in Women with BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer (SOROCk)

Clinicaltrials.gov identifier:
NCT04251052

Prevention
Ovarian cancer prevention for women with a BRCA1 mutation who still have their ovaries

PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease

PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease

Clinicaltrials.gov identifier:
NCT04472338

Prevention
Screening study for people with a mutation linked to prostate cancer risk

Ethical Challenges and Best Practices in End-of-Life Care

Ethical Challenges and Best Practices in End-of-Life Care

Surveys, Registries, Interviews
Interview of palliative care patients and/or their adult family members who have been offered and involved in genetic testing or counseling

Immunotherapy and PARP Inhibitor for Advanced or Metastatic Breast, Ovarian or Pancreatic Cancer with a BRCA Mutation

Immunotherapy and PARP Inhibitor for Advanced or Metastatic Breast, Ovarian or Pancreatic Cancer with a BRCA Mutation

Clinicaltrials.gov identifier:
NCT04673448

Treatment
Treatment study for people with advanced breast, ovarian or pancreatic cancer and an inherited or tumor BRCA mutation

The DETECT Study: Detecting Endometrial Cancer in Tampons

The DETECT Study: Detecting Endometrial Cancer in Tampons

Clinicaltrials.gov identifier:
NCT03538665

Prevention
Early detection of endometrial cancer in women over 45 years of age who are undergoing hysterectomy surgery at the University of Alabama

Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome

Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome

Clinicaltrials.gov identifier:
NCT05419011

Prevention
Testing a combination of vaccines for cancer prevention in Lynch syndrome

UPLIFT: Cancer Caregivers Study

UPLIFT: Cancer Caregivers Study

Surveys, Registries, Interviews
Survey for cancer caregivers of an LGBTQIA+ family member or friend

Effectiveness of Lymph Node Mapping to Reduce the Risk of Swelling in the Legs in Patients with Stage I Endometrial Cancer

Effectiveness of Lymph Node Mapping to Reduce the Risk of Swelling in the Legs in Patients with Stage I Endometrial Cancer

Clinicaltrials.gov identifier:
NCT05646316

Treatment
People with stage I endometrial cancer who are having a hysterectomy

Treatment Studies for People with ER-Positive, HER2-Negative Advanced or Metastatic Breast Cancer (TACTIVE-U)

Treatment Studies for People with ER-Positive, HER2-Negative Advanced or Metastatic Breast Cancer (TACTIVE-U)

Treatment
Treatment for ER-positive, HER2-negative metastatic breast cancer

The LiFT UP Li-Fraumeni & TP53: Understanding & Progress Study

The LiFT UP Li-Fraumeni & TP53: Understanding & Progress Study

Clinicaltrials.gov identifier:
NCT04541654

Surveys, Registries, Interviews
Study looking at cancer risk for people with Li-Fraumeni syndrome

Registry to Discover New Treatments and Developmental Processes of Colorectal and Endometrial Cancer in Patients with Hereditary Cancer

Registry to Discover New Treatments and Developmental Processes of Colorectal and Endometrial Cancer in Patients with Hereditary Cancer

Clinicaltrials.gov identifier:
NCT06096688

Surveys, Registries, Interviews
Study to collect and save data, cancer samples, and cancer family health histories from people who screen for colorectal endometrial cancer

The Phoenix Trial: Cemiplimab for Patients with Localized dMMR Colon Cancer

The Phoenix Trial: Cemiplimab for Patients with Localized dMMR Colon Cancer

Clinicaltrials.gov identifier:
NCT05961709

Treatment
This study will examine how well Cemiplimab works for patients with localized colon cancer who have dMMR

ShareForCures®: Susan G. Komen's People-Powered, Data-Driven Breast Cancer Research Registry

ShareForCures®: Susan G. Komen's People-Powered, Data-Driven Breast Cancer Research Registry

Clinicaltrials.gov identifier:
NCT05654246

Surveys, Registries, Interviews
Registry for anyone diagnosed with breast cancer

The Risk Factor Analysis of Hereditary Breast and Ovarian Cancer In Women with BRCA1, BRCA2 or PALB2 Mutations

The Risk Factor Analysis of Hereditary Breast and Ovarian Cancer In Women with BRCA1, BRCA2 or PALB2 Mutations

Surveys, Registries, Interviews
Study for people who have a BRCA1, BRCA2, or PALB2 genetic mutation

Testing a Vaccine for Treating or Preventing Triple-Negative Breast Cancer

Testing a Vaccine for Treating or Preventing Triple-Negative Breast Cancer

Clinicaltrials.gov identifier:
NCT04674306

Treatment
Treatment study for people with stage 2 or 3 triple-negative breast cancer at high risk for recurrence

Study of the Drug Sovilnesib in People with Ovarian Cancer

Study of the Drug Sovilnesib in People with Ovarian Cancer

Clinicaltrials.gov identifier:
NCT06084416

Treatment
Treatment study for people with platinum-resistant ovarian cancer

A Survey on Options for Managing Cancer Risk Among Women with a BRCA1 or BRCA2 Mutation

A Survey on Options for Managing Cancer Risk Among Women with a BRCA1 or BRCA2 Mutation

Surveys, Registries, Interviews
A survey for women with a BRCA1 or BRCA2 mutation

High Dose Testosterone Treatment for People with Metastatic Prostate Cancer and an ATM, CDK12 or CHEK2 Mutation

High Dose Testosterone Treatment for People with Metastatic Prostate Cancer and an ATM, CDK12 or CHEK2 Mutation

Clinicaltrials.gov identifier:
NCT05011383

Treatment
People who have metastatic castration-resistant prostate cancer with an ATM, CDK12, or CHEK2 mutation

Roadmap to Parenthood: A Study about Fertility and Family-Building After Cancer

Roadmap to Parenthood: A Study about Fertility and Family-Building After Cancer

Clinicaltrials.gov identifier:
NCT06050135

Surveys, Registries, Interviews
A survey for people aged 18-45, assigned female at birth, and history of a cancer diagnosis

Screening Study for Men at High Genetic Risk for Prostate Cancer

Screening Study for Men at High Genetic Risk for Prostate Cancer

Clinicaltrials.gov identifier:
NCT03805919

Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or other mutation

Carboplatin Chemotherapy before Surgery for Patients with High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

Carboplatin Chemotherapy before Surgery for Patients with High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

Clinicaltrials.gov identifier:
NCT05806515

Treatment
Treatment before surgery for people with high-risk prostate cancer and an inherited BRCA1 or BRCA2 gene mutation

Study of a New Immunotherapy Treatment Called NC410 in People with Different Types of Advanced or Metastatic Cancers

Study of a New Immunotherapy Treatment Called NC410 in People with Different Types of Advanced or Metastatic Cancers

Clinicaltrials.gov identifier:
NCT05572684

Treatment
People with advanced or metastatic colorectal, endometrial, ovarian, stomach, esophageal or other cancers

A Study of the Drug REC-4881 For Treating People with Advanced Cancers with an APC or  AXIN1 Mutation

A Study of the Drug REC-4881 For Treating People with Advanced Cancers with an APC or AXIN1 Mutation

Clinicaltrials.gov identifier:
NCT06005974

Treatment
Treatment study for people with advanced cancer with an APC or AXIN1 mutation

Studying a Combination of Three Drugs to Treat Previously Untreated Metastatic Colorectal Cancer with Certain Tumor Markers

Studying a Combination of Three Drugs to Treat Previously Untreated Metastatic Colorectal Cancer with Certain Tumor Markers

Clinicaltrials.gov identifier:
NCT05217446

Treatment
Study for metastatic colorectal cancer that has not yet been treated

Testing the Safety And Action of the Investigational Drug REC-4881 in People With Familial Adenomatous Polyposis (FAP)

Testing the Safety And Action of the Investigational Drug REC-4881 in People With Familial Adenomatous Polyposis (FAP)

Clinicaltrials.gov identifier:
NCT05552755

Prevention
Prevention study for people with an APC mutation and FAP who have had colectomy surgery

Using ctDNA for Earlier Detection and Treatment  of Recurrence or Spread after Treatment for Stage 3 Colon Cancer

Using ctDNA for Earlier Detection and Treatment of Recurrence or Spread after Treatment for Stage 3 Colon Cancer

Clinicaltrials.gov identifier:
NCT03803553

Treatment
Monitoring and treatment study for people who completed treatment for stage 3 colon cancer

Exploring How People of Caribbean Descent Share Information About Their  Genetic Mutations with  Family Members

Exploring How People of Caribbean Descent Share Information About Their Genetic Mutations with Family Members

Surveys, Registries, Interviews
Survey and interview for people of Caribbean descent who tested positive for a genetic mutation linked to cancer.

Treatment of HER2-positive Colorectal Cancer as First Line Treatment in the Metastatic Setting

Treatment of HER2-positive Colorectal Cancer as First Line Treatment in the Metastatic Setting

Clinicaltrials.gov identifier:
NCT05253651

Treatment
People with HER2-positive colorectal cancer who have not yet received treatment in the metastatic setting

Study of Colorectal Cancer and Genetics in Hispanic and Latino People (ENLACE Study)

Study of Colorectal Cancer and Genetics in Hispanic and Latino People (ENLACE Study)

Treatment
Hispanic and Latino people diagnosed with colorectal cancer

Testing a Vaccine for Preventing or Treating Triple-Negative Breast Cancer

Testing a Vaccine for Preventing or Treating Triple-Negative Breast Cancer

Clinicaltrials.gov identifier:
NCT04674306

Prevention
Prevention study for people with a BRCA1, BRCA2 or PALB2 inherited mutation who are planning to undergo risk-reducing mastectomy

Pancreatic Cancer Early Detection for People  at High Risk

Pancreatic Cancer Early Detection for People at High Risk

Clinicaltrials.gov identifier:
NCT04970056

Prevention
Registry and biobank for high risk people undergoing pancreatic cancer screening

Young, Empowered & Strong: Web-Based Symptom Monitoring and Self-Management for Young Adult Breast Cancer Survivors

Young, Empowered & Strong: Web-Based Symptom Monitoring and Self-Management for Young Adult Breast Cancer Survivors

Clinicaltrials.gov identifier:
NCT04906200

Quality of Life
Women diagnosed with breast cancer between the ages of 15-39

Early Detection of Colorectal Cancer for People with Lynch Syndrome

Early Detection of Colorectal Cancer for People with Lynch Syndrome

Clinicaltrials.gov identifier:
NCT05410977

Prevention
People with Lynch Syndrome at risk for colon cancer

Study of the PARP inhibitor AZD9574 Alone and Combined with Other Cancer Medicines to Treat People with Advanced Solid Cancers (CERTIS1 Study)

Study of the PARP inhibitor AZD9574 Alone and Combined with Other Cancer Medicines to Treat People with Advanced Solid Cancers (CERTIS1 Study)

Clinicaltrials.gov identifier:
NCT05417594

Treatment
Treatment study for people with advanced breast, ovarian, pancreatic or prostate cancer or gliomas

WISDOM Study: Women Informed to Screen Depending on Measures of Risk

WISDOM Study: Women Informed to Screen Depending on Measures of Risk

Clinicaltrials.gov identifier:
NCT02620852

Prevention
Study to determine if breast cancer screening can be made better by personalizing each woman’s mammogram schedule

LIVING WELL: A Web-Based Program to Improve Quality of Life in Ovarian Cancer Survivors

LIVING WELL: A Web-Based Program to Improve Quality of Life in Ovarian Cancer Survivors

Clinicaltrials.gov identifier:
NCT04533763

Quality of Life
A research program offering mindfulness, coping, and healthy lifestyle skills for ovarian cancer survivors

Screening in Men at High Risk of Developing Prostate Cancer

Screening in Men at High Risk of Developing Prostate Cancer

Clinicaltrials.gov identifier:
NCT05608694

Prevention
Screening using MRI for men at risk of developing prostate cancer

My Best GI Eating Study

My Best GI Eating Study

Clinicaltrials.gov identifier:
NCT05396846

Prevention
Diet and weight loss study for people who are overweight and at increased risk of colorectal cancer

Observing People and Families Affected by Li-Fraumeni Syndrome (TP53 Mutation )

Observing People and Families Affected by Li-Fraumeni Syndrome (TP53 Mutation )

Clinicaltrials.gov identifier:
NCT01443468

Surveys, Registries, Interviews
Registry for people with Li-Fraumeni syndrome (LFS) or from LFS families

Registry to Promote Health Equity for People of African Ancestry with Breast or Prostate Cancer

Registry to Promote Health Equity for People of African Ancestry with Breast or Prostate Cancer

Clinicaltrials.gov identifier:
NCT05754658

Surveys, Registries, Interviews
This is a registry for people of African ancestry who have breast or prostate cancer

A Surveillance Program for Women at High Risk for Breast Cancer (CAPSBRACA)

A Surveillance Program for Women at High Risk for Breast Cancer (CAPSBRACA)

Clinicaltrials.gov identifier:
NCT03729115

Surveys, Registries, Interviews
Screening study for women at risk for breast cancer due to an inherited mutation or other risk factor

Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy

Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy

Clinicaltrials.gov identifier:
NCT05287451

Prevention
Prevention study for women at high risk for ovarian cancer

Coaching for Family Caregivers of People with Advanced Cancer from Rural and Minority Communities

Coaching for Family Caregivers of People with Advanced Cancer from Rural and Minority Communities

Clinicaltrials.gov identifier:
NCT04318886

Quality of Life
Quality of life study for caregivers involving in-person or telephone coaching sessions

Testing the Drug Obeticholic Acid for Familial Adenomatous Polyposis

Testing the Drug Obeticholic Acid for Familial Adenomatous Polyposis

Clinicaltrials.gov identifier:
NCT05223036

Prevention
Prevention study for people with an APC mutation and FAP or AFAP who have polyps in remaining tissue after colectomy surgery

Nipple Sparing Mastectomy With Immediate Implant-Based Reconstruction for Women With Early-Stage Breast Cancer

Nipple Sparing Mastectomy With Immediate Implant-Based Reconstruction for Women With Early-Stage Breast Cancer

Clinicaltrials.gov identifier:
NCT05720039

Treatment
Nipple sparing mastectomy with reconstruction for women with early-stage breast cancer

Testing  a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation

Testing a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation

Clinicaltrials.gov identifier:
NCT04367675

Prevention
People with a BRCA1 or BRCA2 mutation

Survey about Motivations and Barriers to Talking with Family Members about Inherited Cancer Risk

Survey about Motivations and Barriers to Talking with Family Members about Inherited Cancer Risk

Surveys, Registries, Interviews
Survey for people with an inherited gene mutation

A Study of  Targeted Therapies for Patients With Recurrent Endometrial Cancer

A Study of Targeted Therapies for Patients With Recurrent Endometrial Cancer

Clinicaltrials.gov identifier:
NCT04486352

Treatment
This study is for people with recurrent endometrial cancer

Studying the Use of Naproxen and Aspirin for Cancer Prevention in People with Lynch Syndrome

Studying the Use of Naproxen and Aspirin for Cancer Prevention in People with Lynch Syndrome

Clinicaltrials.gov identifier:
NCT05411718

Prevention
Prevention study for people with Lynch syndrome

Kindred Study

Kindred Study

Surveys, Registries, Interviews
Interviews with African American people who tested positive for a genetic mutation

Testing an Immunotherapy in Patients with Advanced Solid Tumors

Testing an Immunotherapy in Patients with Advanced Solid Tumors

Clinicaltrials.gov identifier:
NCT02628067

Treatment
Treatment study for people with advanced cancers

TAPUR Study: Testing FDA Approved Drugs Targeting Tumor Biomarkers in People with Advanced Stage Cancer

TAPUR Study: Testing FDA Approved Drugs Targeting Tumor Biomarkers in People with Advanced Stage Cancer

Clinicaltrials.gov identifier:
NCT02693535

Treatment
Cancer treatment study for people with advanced solid tumors

Self -Perception and Intimacy After the Cancer Experience (SPICE)

Self -Perception and Intimacy After the Cancer Experience (SPICE)

Surveys, Registries, Interviews
Online survey for cancer survivors ages 18-39 years old about sexual health

Metastatic Castration Resistant Prostate Cancer Clinical Trial

Metastatic Castration Resistant Prostate Cancer Clinical Trial

Clinicaltrials.gov identifier:
NCT03460977

Treatment
This clinical trial is studying a potential treatment for men with metastatic castration resistant prostate cancer.

Breastfeeding and Breast Cancer Screening in People at High Risk: Knowledge and Perspectives

Breastfeeding and Breast Cancer Screening in People at High Risk: Knowledge and Perspectives

Surveys, Registries, Interviews
Online survey for women with an ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, RAD51C, RAD51D, STK11 or TP53 inherited mutation.

Opening the Conversation

Opening the Conversation

Clinicaltrials.gov identifier:
NCT04806724

Quality of Life
Online communication program for breast and gynecologic cancer survivors and their partners

Treating Metastatic Solid Tumors with an Inherited or Acquired Gene Mutation Using the PARP Inhibitor Talazoparib

Treating Metastatic Solid Tumors with an Inherited or Acquired Gene Mutation Using the PARP Inhibitor Talazoparib

Clinicaltrials.gov identifier:
NCT04550494

Treatment
Treatment study for people with advanced solid tumors

Survey for People Diagnosed with Breast Cancer to Provide Feedback on a New Type of Clinical Trial

Survey for People Diagnosed with Breast Cancer to Provide Feedback on a New Type of Clinical Trial

Surveys, Registries, Interviews
Survey for people diagnosed with stage 0 - stage 3 breast cancer

Effect of Acupuncture on Memory and Thinking Difficulties after Breast Cancer

Effect of Acupuncture on Memory and Thinking Difficulties after Breast Cancer

Clinicaltrials.gov identifier:
NCT04837820

Quality of Life
Acupuncture study for people with memory issues who completed treatment for stage 0-3 breast cancer

Restoring Sensation after DIEP Flap Reconstruction

Restoring Sensation after DIEP Flap Reconstruction

Clinicaltrials.gov identifier:
NCT04533373

Prevention
Study for people undergoing DIEP flap reconstruction

Olaparib or Placebo in Patients with Surgically Removed Pancreatic Cancer who have a BRCA1, BRCA2 or PALB2 Mutation

Olaparib or Placebo in Patients with Surgically Removed Pancreatic Cancer who have a BRCA1, BRCA2 or PALB2 Mutation

Clinicaltrials.gov identifier:
NCT04858334

Treatment
Treatment study for pancreatic cancer in people with a BRCA1, BRCA2, or PALB2 mutation

Tools To Be Fit: Tools to Improve Nutrition and Physical Activity for Cancer Survivors

Tools To Be Fit: Tools to Improve Nutrition and Physical Activity for Cancer Survivors

Clinicaltrials.gov identifier:
NCT05056077

Quality of Life
Bladder, breast, colon, endometrial, kidney (renal cell carcinoma), ovarian, prostate, or rectal cancer

Factors Influencing Disparities in Quality of Life among People of Color Affected by Cancer

Factors Influencing Disparities in Quality of Life among People of Color Affected by Cancer

Surveys, Registries, Interviews
Survey for people of color who have completed treatment for cancer

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Clinicaltrials.gov identifier:
NCT05129605

Prevention
People at high risk for prostate cancer due to an inherited mutation

NUV-868 Alone and in Combination With PARP Inhibitors in Patients With Advanced Solid Tumors

NUV-868 Alone and in Combination With PARP Inhibitors in Patients With Advanced Solid Tumors

Clinicaltrials.gov identifier:
NCT05252390

Treatment
Treatment study for people with advanced solid tumors, including triple-negative breast, ovarian, pancreatic and prostate cancer

Treating Metastatic Prostate Cancer with Chemotherapy or PARP Inhibitor in People with Mutations (COBRA)

Treating Metastatic Prostate Cancer with Chemotherapy or PARP Inhibitor in People with Mutations (COBRA)

Clinicaltrials.gov identifier:
NCT04038502

Treatment
Treatment study for mCRPC with an inherited or tumor mutation in BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2, RAD51B, RAD51C, RAD51D or RAD54L

Blood Markers of Early Pancreas Cancer

Blood Markers of Early Pancreas Cancer

Clinicaltrials.gov identifier:
NCT03568630

Prevention
Observational study for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk

Helping Latinas Understand Their Risk for Breast Cancer and Get Breast Cancer Care

Helping Latinas Understand Their Risk for Breast Cancer and Get Breast Cancer Care

Clinicaltrials.gov identifier:
NCT05483283

Prevention
Latinas with a high risk of breast cancer

Upright MRI for Prostate Cancer Screening

Upright MRI for Prostate Cancer Screening

Clinicaltrials.gov identifier:
NCT03474913

Prevention
Screening for prostate cancer using upright MRI

Bazedoxifene Plus Conjugated Estrogens for Hot Flashes in Women at High Risk for Breast Cancer

Bazedoxifene Plus Conjugated Estrogens for Hot Flashes in Women at High Risk for Breast Cancer

Clinicaltrials.gov identifier:
NCT04821141

Quality of Life
Women at high risk for breast cancer due to ATM, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, STK11, P53 or PTEN mutation who have hot flashes

Research Opportunity for Previvors and their Romantic Partners

Research Opportunity for Previvors and their Romantic Partners

Surveys, Registries, Interviews
Interview for people with inherited mutations who had risk-reducing mastectomy and their partners

BRCA 1 and BRCA 2: Interviews on Genetic Testing and Individual Experiences

BRCA 1 and BRCA 2: Interviews on Genetic Testing and Individual Experiences

Surveys, Registries, Interviews
People with or without cancer who have had or are considering BRCA testing

Cancer Experience Registry

Cancer Experience Registry

Surveys, Registries, Interviews
Online survey for patients and caregivers focusing on multiple aspects of cancer

SHARON: A Clinical Trial for Metastatic Cancer With an Inherited BRCA or PALB2 Mutation Using Chemotherapy and Patients’ Own Stem Cells

SHARON: A Clinical Trial for Metastatic Cancer With an Inherited BRCA or PALB2 Mutation Using Chemotherapy and Patients’ Own Stem Cells

Clinicaltrials.gov identifier:
NCT04150042

Treatment
Advanced pancreatic cancer or stage 4 breast cancer in people with a BRCA1 or BRCA2 mutation

Helping People With a Genetic Mutation in BRCA1, BRCA2 or Lynch Syndrome Talk to Their Family Members About Their Risk for Cancer and Find the Best Way to Get Family Members Tested

Helping People With a Genetic Mutation in BRCA1, BRCA2 or Lynch Syndrome Talk to Their Family Members About Their Risk for Cancer and Find the Best Way to Get Family Members Tested

Clinicaltrials.gov identifier:
NCT05677048

Prevention
People with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome who have relatives who have not been tested

All of Us Research Program

All of Us Research Program

Surveys, Registries, Interviews
Anyone age 18 or over can participate in this research study

Treating Early-Stage Breast Cancer  with a PARP Inhibitor (Niraparib) and Immunotherapy (Dostarlimab) in People with  a BRCA or PALB2 Mutation

Treating Early-Stage Breast Cancer with a PARP Inhibitor (Niraparib) and Immunotherapy (Dostarlimab) in People with a BRCA or PALB2 Mutation

Clinicaltrials.gov identifier:
NCT04584255

Treatment
Treatment before surgery for people with early-stage breast cancer & a BRCA1, BRCA2 or PALB2 mutation

Investigational PARP Inhibitor AZD5305 Alone or Combined With Other Anti-cancer Agents in People With Advanced Solid Tumors (PETRA)

Investigational PARP Inhibitor AZD5305 Alone or Combined With Other Anti-cancer Agents in People With Advanced Solid Tumors (PETRA)

Clinicaltrials.gov identifier:
NCT04644068

Treatment
Advanced ovarian, breast, prostate or pancreatic cancer

Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed

Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed

Clinicaltrials.gov identifier:
NCT03231891

Surveys, Registries, Interviews
People with an inherited mutation or cancer in the family

Adding Pembrolizumab to Olaparib to Treat Pancreatic Cancer in People with an Inherited BRCA Mutation

Adding Pembrolizumab to Olaparib to Treat Pancreatic Cancer in People with an Inherited BRCA Mutation

Clinicaltrials.gov identifier:
NCT04548752

Treatment
Metastatic pancreatic cancer and a BRCA1 or BRCA2 mutation

Treatment with ATR Inhibitor for Advanced or Metastatic Solid Tumors

Treatment with ATR Inhibitor for Advanced or Metastatic Solid Tumors

Clinicaltrials.gov identifier:
NCT04657068

Treatment
Advanced solid tumors

Nivolumab and Relatlimab in Advanced MSI-H Cancers Resistant to Prior PD-L1 Inhibitor

Nivolumab and Relatlimab in Advanced MSI-H Cancers Resistant to Prior PD-L1 Inhibitor

Clinicaltrials.gov identifier:
NCT03607890

Treatment
Solid tumors that are MSI-High and resistant to prior immunotherapy

Developing a Test for the Detection of Ovarian Cancer

Developing a Test for the Detection of Ovarian Cancer

Clinicaltrials.gov identifier:
NCT04794322

Prevention
Prevention study for women with a BRCA1 or BRCA2 mutation who are scheduled for risk-reducing salpingo-oophorectomy

Chemotherapy, Bevacizumab, and/or Atezolizumab for dMMR / MSI-H Metastatic Colorectal Cancer (COMMIT Study)

Chemotherapy, Bevacizumab, and/or Atezolizumab for dMMR / MSI-H Metastatic Colorectal Cancer (COMMIT Study)

Clinicaltrials.gov identifier:
NCT02997228

Treatment
This is a treatment study is for people with metastatic colorectal cancer

Screening for Pancreatic Cancer in Patients with an Inherited BRCA1, BRCA2, PALB2 or ATM Mutation

Screening for Pancreatic Cancer in Patients with an Inherited BRCA1, BRCA2, PALB2 or ATM Mutation

Clinicaltrials.gov identifier:
NCT02478892

Prevention
Pancreatic cancer screening for people at high risk and with an inherited BRCA1, BRCA2, ATM, or PALB2 mutation

Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

Clinicaltrials.gov identifier:
NCT04042831

Treatment
Treatment study for people diagnosed with metastatic biliary tract (bile duct) cancer and who have an inherited or tumor mutation in ATM, BRCA 1/2, BRIP1, CHEK2, RAD51C, RAD51D, PALB2, PTEN, NBN and others

Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families

Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families

Prevention
Screening study for women with a BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, PMS2, MLH1, MSH2, MSH6, or EPCAM mutation

Pembrolizumab and Olaparib for Metastatic Pancreatic Cancer with Homologous Recombination Deficiency or Exceptional Response to Platinum Chemotherapy

Pembrolizumab and Olaparib for Metastatic Pancreatic Cancer with Homologous Recombination Deficiency or Exceptional Response to Platinum Chemotherapy

Clinicaltrials.gov identifier:
NCT04666740

Treatment
Treatment study for people diagnosed with metastatic pancreatic cancer with Homologous Recombination Deficiency, or whose disease has responded well to first-line or second-line platinum therapy

Blood Tests to Measure Ovarian Reserves in Women with a BRCA Mutation or Women Treated for Early-Stage Breast Cancer

Blood Tests to Measure Ovarian Reserves in Women with a BRCA Mutation or Women Treated for Early-Stage Breast Cancer

Clinicaltrials.gov identifier:
NCT00823654

Prevention
Study for premenopausal women with early-stage breast cancer and high-risk women with BRCA mutations and no evidence of breast or ovarian cancer

Talazoparib for People with Metastatic Breast Cancer Who Have Acquired (Somatic) BRCA Mutations

Talazoparib for People with Metastatic Breast Cancer Who Have Acquired (Somatic) BRCA Mutations

Clinicaltrials.gov identifier:
NCT03990896

Treatment
This is a study for people with metastatic breast cancer without a known mutation in BRCA1 or BRCA2, who learn they have a BRCA1 or BRCA2 acquired tumor mutation (somatic mutation) found through liquid biopsy

Metastatic Prostate Cancer Project

Metastatic Prostate Cancer Project

Surveys, Registries, Interviews
A nationwide genomic research study for men with advanced and/or metastatic prostate cancer

The Metastatic Breast Cancer Project

The Metastatic Breast Cancer Project

Surveys, Registries, Interviews
A nationwide genomic research study for people with advanced and/or metastatic breast cancer

Pancreatic Cancer Screening Study for High Risk People

Pancreatic Cancer Screening Study for High Risk People

Clinicaltrials.gov identifier:
NCT03250078

Prevention
Screening study to detect pancreatic cancer and precancer in people with either a strong family history of pancreatic cancer, or an inherited mutation associated with pancreatic cancer risk

Connect My Variant

Connect My Variant

Surveys, Registries, Interviews
Study for people with an inherited mutation to help them talk with relatives about their family history and genetic test results, connect them to others with the same variant and to their family trees

Study for People with Unexpected Genetic Results

Study for People with Unexpected Genetic Results

Clinicaltrials.gov identifier:
NCT02595957

Prevention
This study is recruiting people who received unexpected genetic test results about their cancer risk after having genetic testing done for some other reason

Talking to Employers and Medical Staff About Breast Cancer Treatment and Your Job

Talking to Employers and Medical Staff About Breast Cancer Treatment and Your Job

Clinicaltrials.gov identifier:
NCT03572374

Quality of Life
Study for people diagnosed with cancer to help them navigate wok-related issues

Breast Cancer Treatment in Women with PALB2 Mutations

Breast Cancer Treatment in Women with PALB2 Mutations

Surveys, Registries, Interviews
The PALB2 Study is an international research study to better understand breast cancer treatment among women with a PALB2 gene mutation.

ELLIE's Project

ELLIE's Project

Quality of Life
A survey to gain a better understanding of the baseline lifestyle factors related to nutrition and physical activity in people with a hereditary cancer gene mutation.

Identification and Analysis of Families With Genetic Susceptibility To Cancer Registry

Identification and Analysis of Families With Genetic Susceptibility To Cancer Registry

Surveys, Registries, Interviews
Registry for people with an inherited mutation in BRCA1 or BRCA2, or a BRCA1 or BRCA2 variant of uncertain significance, a gene mutation linked to a Lynch syndrome or an inherited mutation in another cancer risk gene


Sponsored By: