Featured Research

Understanding Risk Factors for Stomach Cancer in People with Inherited Mutations

Surveys, Registries, Interviews
Online survey on stomach cancer risk for people with an inherited mutation in genes that are linked to an increased risk of certain cancers

Treating Advanced Cancers with DNA-Repair Mutations Using MOMA-313 Alone or In Combination with the PARP Inhibitor Olaparib

Clinicaltrials.gov identifier:
NCT06545942

Treatment
Treatment study for people with advanced or metastatic cancers

NePtune: Using PARP Inhibitors Before Surgery in Localized Prostate Cancer

Clinicaltrials.gov identifier:
NCT05498272

Treatment
Treatment study for people with intermediate- or high-risk prostate cancer with certain tumor mutations

Pfizer Clinical Trials for Metastatic Prostate Cancer are Now Enrolling

Treatment
Men aged 18 years or older with metastatic prostate cancer

Study of a New InvestigationaI Inhibitor to Treat People with Advanced Solid Tumors

Clinicaltrials.gov identifier:
NCT05932862

Treatment
Treatment study for people with advanced solid tumors

Research Study on the Genetics of Breast Cancer

Surveys, Registries, Interviews
This population-based research study aims to enroll at least 10,000 people aged 18 and older who live in the United States. A diagnosis of cancer is NOT required. Participants may receive information about their genetic ancestry for free

PROMISE Registry: A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness

Clinicaltrials.gov identifier:
NCT04995198

Surveys, Registries, Interviews
A screening registry for people diagnosed with prostate cancer

Acting on Cancer Testing Together (ACT-Together)

Prevention
This is a study for women diagnosed with BRCA 1 or BRCA2 focused on increasing education on options for reducing cancer risk associated with their diagnosis

Screening Study for Pancreatic Cancer in People with Inherited Mutations

Clinicaltrials.gov identifier:
NCT05058846

Prevention
Pancreatic cancer screening study for people with ATM, BRCA1, BRCA2 or PALB2 mutations

What Happens to Tissue or Blood Samples you Donate as Part of Research?

Surveys, Registries, Interviews
Survey to share your views on a new method to track research specimens

Registry for People at Increased Risk for Pancreatic Cancer

Clinicaltrials.gov identifier:
NCT06151223

Surveys, Registries, Interviews
Study collecting blood samples and imaging records of people at high risk of developing pancreatic cancer

Study of the Drug Olvi-Vec in Women with Ovarian Cancer

Clinicaltrials.gov identifier:
NCT05281471

Treatment
Treatment for women diagnosed with platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer or whose cancer did not respond to prior chemotherapy

The American Cancer Society’s “VOICES of Black Women” Observational Study

Surveys, Registries, Interviews
VOICES of Black Women is a study led by the American Cancer Society to better understand cancer and other health conditions among Black women

Olaparib with Cediranib or Ceralasertib for People with Advanced or Metastatic Breast Cancer and with a BRCA1 or BRCA2 Mutation

Clinicaltrials.gov identifier:
NCT04090567

Treatment
Treatment study for people with advanced breast cancer who have a BRCA1 or BRCA2 genetic mutation and who were previously treated with a PARP inhibitor

Treating Metastatic BRCA1, BRCA2 or PALB2 Pancreatic Cancer Using a New Combination of Chemotherapy Drugs

Clinicaltrials.gov identifier:
NCT06115499

Treatment
Treatment study for people with metastatic pancreatic cancer and a BRCA1, BRCA2 or PALB2 mutation

Sexual Health and Rehabilitation Online (SHAREonline): An Educational Intervention for Young Women after Cancer

Clinicaltrials.gov identifier:
NCT06458049

Quality of Life
An online study comparing two educational interventions for female cancer survivors experiencing sexual health changes

Understanding the Emotional and Social Experiences of Individuals Diagnosed with Ovarian Cancer

Surveys, Registries, Interviews
Survey for people diagnosed with ovarian cancer

CHANCES: Studying the Connection Between Chemotherapy Exposure and Secondary Cancers of the Blood in Ovarian and other Cancer Survivors

Clinicaltrials.gov identifier:
NCT06295965

Prevention
Study focusing on improving outcomes for ovarian and other cancer survivors

Treating Metastatic Prostate Cancer with a New PARP Inhibitor AZD5305 Combined With Hormone Therapy

Clinicaltrials.gov identifier:
NCT05367440

Treatment
Treatment study for metastatic prostate cancer

Pancreatic Cancer Screening Study (CAPS5)

Clinicaltrials.gov identifier:
NCT02000089

Prevention
Screening study for people at high risk for pancreatic cancer

Cancer Risk Perception and Management of Individuals With a BRCA1 or BRCA2 Mutation Who Were Assigned Male at Birth (AMAB)

Surveys, Registries, Interviews
Research study enrolling individuals assigned male at birth (AMAB) who are a confirmed carrier of a BRCA1 and/or BRCA2 mutation

Cognitive Training for Breast Cancer Survivors with Memory and Thinking Problems

Clinicaltrials.gov identifier:
NCT05896189

Quality of Life
How well cognitive training helps breast cancer survivors with their memory and thinking problems

A Study to Compare Two Surgical Procedures in Women with BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer (SOROCk)

Clinicaltrials.gov identifier:
NCT04251052

Prevention
Ovarian cancer prevention for women with a BRCA1 mutation who still have their ovaries

PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease

Clinicaltrials.gov identifier:
NCT04472338

Prevention
Screening study for people with a mutation linked to prostate cancer risk

Social Support and Coping Strategies Among LGBTQIA+ Cancer Patients

Surveys, Registries, Interviews
This study explores how different levels of support systems influence coping strategies among LGBTQIA+ cancer patients

Understanding the Cancer Journey: A Survey of Patient Experiences and Emotional Impact

Surveys, Registries, Interviews
Online survey for people diagnosed with breast, colorectal, gastric or prostate cancer within the past twenty years

Immunotherapy and PARP Inhibitor for Advanced or Metastatic Breast, Ovarian or Pancreatic Cancer with a BRCA Mutation

Clinicaltrials.gov identifier:
NCT04673448

Treatment
Treatment study for people with advanced breast, ovarian or pancreatic cancer and an inherited or tumor BRCA mutation

The DETECT Study: Detecting Endometrial Cancer in Tampons

Clinicaltrials.gov identifier:
NCT03538665

Prevention
Early detection of endometrial cancer in women over 45 years of age who are undergoing hysterectomy surgery at the University of Alabama

Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome

Clinicaltrials.gov identifier:
NCT05419011

Prevention
Testing a combination of vaccines for cancer prevention in Lynch syndrome

Effectiveness of Lymph Node Mapping to Reduce the Risk of Swelling in the Legs in Patients with Stage I Endometrial Cancer

Clinicaltrials.gov identifier:
NCT05646316

Treatment
People with stage I endometrial cancer who are having a hysterectomy

The LiFT UP Li-Fraumeni & TP53: Understanding & Progress Study

Clinicaltrials.gov identifier:
NCT04541654

Surveys, Registries, Interviews
Study looking at cancer risk for people with Li-Fraumeni syndrome

Roadmap to Parenthood: A Study about Fertility and Family-Building After Cancer

Clinicaltrials.gov identifier:
NCT06050135

Surveys, Registries, Interviews
A survey for people aged 18-45, assigned female at birth, and history of a cancer diagnosis

Registry to Discover New Treatments and Developmental Processes of Colorectal and Endometrial Cancer in Patients with Hereditary Cancer

Clinicaltrials.gov identifier:
NCT06096688

Surveys, Registries, Interviews
Study to collect and save data, cancer samples, and cancer family health histories from people who screen for colorectal endometrial cancer

New Treatment in People with Triple Negative Breast Cancer or Advanced Solid Tumors

Clinicaltrials.gov identifier:
NCT06022029

Treatment
Treatment study for people with triple negative breast cancer, advanced solid tumors or lymphomas

The Phoenix Trial: Cemiplimab for Patients with Localized dMMR Colon Cancer

Clinicaltrials.gov identifier:
NCT05961709

Treatment
This study will examine how well Cemiplimab works for patients with localized colon cancer who have dMMR

ShareForCures®: Susan G. Komen's People-Powered, Data-Driven Breast Cancer Research Registry

Clinicaltrials.gov identifier:
NCT05654246

Surveys, Registries, Interviews
Registry for anyone diagnosed with breast cancer

The Risk Factor Analysis of Hereditary Breast and Ovarian Cancer In Women with BRCA1, BRCA2 or PALB2 Mutations

Surveys, Registries, Interviews
Study for people who have a BRCA1, BRCA2, or PALB2 genetic mutation

Testing a Vaccine for Treating or Preventing Triple-Negative Breast Cancer

Clinicaltrials.gov identifier:
NCT04674306

Treatment
Treatment study for people with stage 2 or 3 triple-negative breast cancer at high risk for recurrence

Study of the Drug Sovilnesib in People with Ovarian Cancer

Clinicaltrials.gov identifier:
NCT06084416

Treatment
Treatment study for people with platinum-resistant ovarian cancer

High Dose Testosterone Treatment for People with Metastatic Prostate Cancer and an ATM, CDK12 or CHEK2 Mutation

Clinicaltrials.gov identifier:
NCT05011383

Treatment
People who have metastatic castration-resistant prostate cancer with an ATM, CDK12, or CHEK2 mutation

Screening Study for Men at High Genetic Risk for Prostate Cancer

Clinicaltrials.gov identifier:
NCT03805919

Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or other mutation

Carboplatin Chemotherapy before Surgery for Patients with High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

Clinicaltrials.gov identifier:
NCT05806515

Treatment
Treatment before surgery for people with high-risk prostate cancer and an inherited BRCA1 or BRCA2 gene mutation

Testing the Safety And Action of the Investigational Drug REC-4881 in People With Familial Adenomatous Polyposis (FAP)

Clinicaltrials.gov identifier:
NCT05552755

Prevention
Prevention study for people with an APC mutation and FAP who have had colectomy surgery

Using ctDNA for Earlier Detection and Treatment of Recurrence or Spread after Treatment for Stage 3 Colon Cancer

Clinicaltrials.gov identifier:
NCT03803553

Treatment
Monitoring and treatment study for people who completed treatment for stage 3 colon cancer

Treatment of HER2-positive Colorectal Cancer as First Line Treatment in the Metastatic Setting

Clinicaltrials.gov identifier:
NCT05253651

Treatment
People with HER2-positive colorectal cancer who have not yet received treatment in the metastatic setting

Study of Colorectal Cancer and Genetics in Hispanic and Latino People (ENLACE Study)

Treatment
Hispanic and Latino people diagnosed with colorectal cancer

Testing a Vaccine for Preventing or Treating Triple-Negative Breast Cancer

Clinicaltrials.gov identifier:
NCT04674306

Prevention
Prevention study for people with a BRCA1, BRCA2 or PALB2 inherited mutation who are planning to undergo risk-reducing mastectomy

Pancreatic Cancer Early Detection for People at High Risk

Clinicaltrials.gov identifier:
NCT04970056

Prevention
Registry and biobank for high risk people undergoing pancreatic cancer screening

Early Detection of Colorectal Cancer for People with Lynch Syndrome

Clinicaltrials.gov identifier:
NCT05410977

Prevention
People with Lynch Syndrome at risk for colon cancer

Study of the PARP inhibitor AZD9574 Alone and Combined with Other Cancer Medicines to Treat People with Advanced Solid Cancers (CERTIS1 Study)

Clinicaltrials.gov identifier:
NCT05417594

Treatment
Treatment study for people with advanced breast, ovarian, pancreatic or prostate cancer or gliomas

WISDOM Study: Women Informed to Screen Depending on Measures of Risk

Clinicaltrials.gov identifier:
NCT02620852

Prevention
Study to determine if breast cancer screening can be made better by personalizing each woman’s mammogram schedule

Screening in Men at High Risk of Developing Prostate Cancer

Clinicaltrials.gov identifier:
NCT05608694

Prevention
Screening using MRI for men at risk of developing prostate cancer

My Best GI Eating Study

Clinicaltrials.gov identifier:
NCT05396846

Prevention
Diet and weight loss study for people who are overweight and at increased risk of colorectal cancer

Observing People and Families Affected by Li-Fraumeni Syndrome (TP53 Mutation )

Clinicaltrials.gov identifier:
NCT01443468

Surveys, Registries, Interviews
Registry for people with Li-Fraumeni syndrome (LFS) or from LFS families

A Surveillance Program for Women at High Risk for Breast Cancer (CAPSBRACA)

Clinicaltrials.gov identifier:
NCT03729115

Surveys, Registries, Interviews
Screening study for women at risk for breast cancer due to an inherited mutation or other risk factor

Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy

Clinicaltrials.gov identifier:
NCT05287451

Prevention
Prevention study for women at high risk for ovarian cancer

Coaching for Family Caregivers of People with Advanced Cancer from Rural and Minority Communities

Clinicaltrials.gov identifier:
NCT04318886

Quality of Life
Quality of life study for caregivers involving in-person or telephone coaching sessions

Testing the Drug Obeticholic Acid for Familial Adenomatous Polyposis

Clinicaltrials.gov identifier:
NCT05223036

Prevention
Prevention study for people with an APC mutation and FAP or AFAP who have polyps in remaining tissue after colectomy surgery

Nipple Sparing Mastectomy With Immediate Implant-Based Reconstruction for Women With Early-Stage Breast Cancer

Clinicaltrials.gov identifier:
NCT05720039

Treatment
Nipple sparing mastectomy with reconstruction for women with early-stage breast cancer

A Study of Targeted Therapies for Patients With Recurrent Endometrial Cancer

Clinicaltrials.gov identifier:
NCT04486352

Treatment
This study is for people with recurrent endometrial cancer

Studying the Use of Naproxen and Aspirin for Cancer Prevention in People with Lynch Syndrome

Clinicaltrials.gov identifier:
NCT05411718

Prevention
Prevention study for people with Lynch syndrome

Kindred Study

Surveys, Registries, Interviews
Interviews with African American people who tested positive for a genetic mutation

Testing an Immunotherapy in Patients with Advanced Solid Tumors

Clinicaltrials.gov identifier:
NCT02628067

Treatment
Treatment study for people with advanced cancers

TAPUR Study: Testing FDA Approved Drugs Targeting Tumor Biomarkers in People with Advanced Stage Cancer

Clinicaltrials.gov identifier:
NCT02693535

Treatment
Cancer treatment study for people with advanced solid tumors

Self -Perception and Intimacy After the Cancer Experience (SPICE)

Surveys, Registries, Interviews
Online survey for cancer survivors ages 18-39 years old about sexual health

Metastatic Castration Resistant Prostate Cancer Clinical Trial

Clinicaltrials.gov identifier:
NCT03460977

Treatment
This clinical trial is studying a potential treatment for men with metastatic castration resistant prostate cancer

Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects

Clinicaltrials.gov identifier:
NCT04030559

Treatment
High-risk localized prostate cancer

Treating Metastatic Solid Tumors with an Inherited or Acquired Gene Mutation Using the PARP Inhibitor Talazoparib

Clinicaltrials.gov identifier:
NCT04550494

Treatment
Treatment study for people with advanced solid tumors

Survey for People Diagnosed with Breast Cancer to Provide Feedback on a New Type of Clinical Trial

Surveys, Registries, Interviews
Survey for people diagnosed with stage 0 - stage 3 breast cancer

Restoring Sensation after DIEP Flap Reconstruction

Clinicaltrials.gov identifier:
NCT04533373

Prevention
Study for people undergoing DIEP flap reconstruction

Olaparib or Placebo in Patients with Surgically Removed Pancreatic Cancer who have a BRCA1, BRCA2 or PALB2 Mutation

Clinicaltrials.gov identifier:
NCT04858334

Treatment
Treatment study for pancreatic cancer in people with a BRCA1, BRCA2, or PALB2 mutation

Tools To Be Fit: Tools to Improve Nutrition and Physical Activity for Cancer Survivors

Clinicaltrials.gov identifier:
NCT05056077

Quality of Life
Bladder, breast, colon, endometrial, kidney (renal cell carcinoma), ovarian, prostate, or rectal cancer

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Clinicaltrials.gov identifier:
NCT05129605

Prevention
People at high risk for prostate cancer due to an inherited mutation

Treating Metastatic Prostate Cancer with Chemotherapy or PARP Inhibitor in People with Mutations (COBRA)

Clinicaltrials.gov identifier:
NCT04038502

Treatment
Treatment study for mCRPC with an inherited or tumor mutation in BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2, RAD51B, RAD51C, RAD51D or RAD54L

Blood Markers of Early Pancreas Cancer

Clinicaltrials.gov identifier:
NCT03568630

Prevention
Observational study for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk

Helping Latinas Understand Their Risk for Breast Cancer and Get Breast Cancer Care

Clinicaltrials.gov identifier:
NCT05483283

Prevention
Latinas with a high risk of breast cancer

Upright MRI for Prostate Cancer Screening

Clinicaltrials.gov identifier:
NCT03474913

Prevention
Screening for prostate cancer using upright MRI

Bazedoxifene Plus Conjugated Estrogens for Hot Flashes in Women at High Risk for Breast Cancer

Clinicaltrials.gov identifier:
NCT04821141

Quality of Life
Women at high risk for breast cancer due to ATM, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, STK11, P53 or PTEN mutation who have hot flashes

BRCA 1 and BRCA 2: Interviews on Genetic Testing and Individual Experiences

Surveys, Registries, Interviews
People with or without cancer who have had or are considering BRCA testing

Cancer Experience Registry

Surveys, Registries, Interviews
Online survey for patients and caregivers focusing on multiple aspects of cancer

SHARON: A Clinical Trial for Metastatic Cancer With an Inherited BRCA or PALB2 Mutation Using Chemotherapy and Patients’ Own Stem Cells

Clinicaltrials.gov identifier:
NCT04150042

Treatment
Advanced pancreatic cancer or stage 4 breast cancer in people with a BRCA1 or BRCA2 mutation

All of Us Research Program

Surveys, Registries, Interviews
Anyone age 18 or over can participate in this research study

Investigational PARP Inhibitor AZD5305 Alone or Combined With Other Anti-cancer Agents in People With Advanced Solid Tumors (PETRA)

Clinicaltrials.gov identifier:
NCT04644068

Treatment
Advanced ovarian, breast, prostate or pancreatic cancer

Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed

Clinicaltrials.gov identifier:
NCT03231891

Surveys, Registries, Interviews
People with an inherited mutation or cancer in the family

Adding Pembrolizumab to Olaparib to Treat Pancreatic Cancer in People with an Inherited BRCA Mutation

Clinicaltrials.gov identifier:
NCT04548752

Treatment
Metastatic pancreatic cancer and a BRCA1 or BRCA2 mutation

Treatment with ATR Inhibitor for Advanced or Metastatic Solid Tumors

Clinicaltrials.gov identifier:
NCT04657068

Treatment
Advanced solid tumors

Nivolumab and Relatlimab in Advanced MSI-H Cancers Resistant to Prior PD-L1 Inhibitor

Clinicaltrials.gov identifier:
NCT03607890

Treatment
Solid tumors that are MSI-High and resistant to prior immunotherapy

Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

Clinicaltrials.gov identifier:
NCT04042831

Treatment
Treatment study for people diagnosed with metastatic biliary tract (bile duct) cancer and who have an inherited or tumor mutation in ATM, BRCA 1/2, BRIP1, CHEK2, RAD51C, RAD51D, PALB2, PTEN, NBN and others

Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families

Prevention
Screening study for women with a BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, PMS2, MLH1, MSH2, MSH6, or EPCAM mutation

Blood Tests to Measure Ovarian Reserves in Women with a BRCA Mutation or Women Treated for Early-Stage Breast Cancer

Clinicaltrials.gov identifier:
NCT00823654

Prevention
Study for premenopausal women with early-stage breast cancer and high-risk women with BRCA mutations and no evidence of breast or ovarian cancer

Talazoparib for People with Metastatic Breast Cancer Who Have Acquired (Somatic) BRCA Mutations

Clinicaltrials.gov identifier:
NCT03990896

Treatment
This is a study for people with metastatic breast cancer without a known mutation in BRCA1 or BRCA2, who learn they have a BRCA1 or BRCA2 acquired tumor mutation (somatic mutation) found through liquid biopsy

Pancreatic Cancer Screening Study for High Risk People

Clinicaltrials.gov identifier:
NCT03250078

Prevention
Screening study to detect pancreatic cancer and precancer in people with either a strong family history of pancreatic cancer, or an inherited mutation associated with pancreatic cancer risk

Connect My Variant

Surveys, Registries, Interviews
Study for people with an inherited mutation to help them talk with relatives about their family history and genetic test results, connect them to others with the same variant and to their family trees

Study for People with Unexpected Genetic Results

Clinicaltrials.gov identifier:
NCT02595957

Prevention
This study is recruiting people who received unexpected genetic test results about their cancer risk after having genetic testing done for some other reason

Talking to Employers and Medical Staff About Breast Cancer Treatment and Your Job

Clinicaltrials.gov identifier:
NCT03572374

Quality of Life
Study for people diagnosed with cancer to help them navigate wok-related issues

Hereditary Breast Cancer Treatment Study (Treatment Study)

Surveys, Registries, Interviews
The Treatment Study is an international research study to better understand breast cancer treatment among individuals with ATM, CHEK2 and PALB2 gene mutations

ELLIE's Project

Quality of Life
A survey to gain a better understanding of the baseline lifestyle factors related to nutrition and physical activity in people with a hereditary cancer gene mutation

Identification and Analysis of Families With Genetic Susceptibility To Cancer Registry

Surveys, Registries, Interviews
Registry for people with an inherited mutation in BRCA1 or BRCA2, or a BRCA1 or BRCA2 variant of uncertain significance, a gene mutation linked to a Lynch syndrome or an inherited mutation in another cancer risk gene