The only way to improve cancer detection, prevention, and treatment is through research. People participating in research contribute to medical knowledge and have opportunity to receive cutting-edge care.
Click on the “Search Now” button to search for research studies enrolling people like you. Need help getting started? Click on “Tips for Searching Studies” to find resources and assistance to help you find studies.

Denosumab for Preventing Breast Cancer in Women with a BRCA1 Inherited Mutation (BRCA-P)
Clinicaltrials.gov identifier:
NCT04711109
Prevention
Prevention study enrolling women ages 25-55 with a BRCA1 mutation

Survey about Endometrial Cancer Risk and Risk-Reducing Surgery for Women with a BRCA1/2 Mutation or Mutation in the Family
Surveys, Registries, Interviews
Women with a BRCA mutation or from a family with a BRCA mutation

EnergyPoints: A Mobile App Guiding Use of Acupressure for Cancer-related Fatigue and Sleep Disturbances
Quality of Life
Anyone diagnosed with cancer experiencing fatigue

PARP inhibitor (niraparib) in patients with inherited or tumor PALB2 mutations in advanced solid tumors (PAVO)
Clinicaltrials.gov identifier:
NCT05169437
Treatment
Any advanced or metastatic solid tumor except ovarian or prostate

TALAPRO-3: A Clinical Trial in Men with Metastatic Castration-Sensitive Prostate Cancer (mCSPC) and DNA Damage Repair (DDR) Gene Alteration
Clinicaltrials.gov identifier:
NCT04821622
Treatment
Metastatic castration-sensitive prostate cancer

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier:
NCT05129605
Prevention
People at high risk for prostate cancer due to an inherited mutation

BRCA 1 and 2: Interviews on Genetic Testing and Individual Experiences
Surveys, Registries, Interviews
People with or without cancer who have had or are considering BRCA testing

UCLA Research Study: Zoom Interviews to Learn from Asian Americans Living with Metastatic Cancer
Surveys, Registries, Interviews
Asian Americans with metastatic cancer of any type

A Study of Melphalan, BCNU, Vitamin B12b, Vitamin C, and Stem Cell Infusion in People with Advanced Pancreatic Cancer and BRCA Mutations
Clinicaltrials.gov identifier:
NCT04150042
Treatment
Advanced pancreatic cancer in people with a BRCA1 or BRCA2 mutation

Interview Study: Exploring Gender Diverse Experiences of Hereditary Cancer Risk
Surveys, Registries, Interviews
People with elevated cancer risk who identify as trans* or nonbinary

RESTORE: A virtual study comparing 2 digital apps to improve mental and physical well-being of patients with stage I – 3 cancer
Clinicaltrials.gov identifier:
NCT05227898
Quality of Life
People with stage 1-3 cancer

Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed
Clinicaltrials.gov identifier:
NCT03231891
Surveys, Registries, Interviews
People with an inherited mutation or cancer in the family

Interviews for people who had a genetic test result that was later reclassified
Surveys, Registries, Interviews
People who had a genetic test result that was later reclassified

Androgen Suppression With Abiraterone, Leuprolide, PARP Inhibitor and Stereotactic Radiotherapy in Prostate Cancer (ASCLEPIuS)
Clinicaltrials.gov identifier:
NCT04194554
Treatment
Newly diagnosed prostate cancer grade group 3-5

Combination ATR inhibitor and PARP Inhibitor in Recurrent Ovarian Cancer (CAPRI)
Clinicaltrials.gov identifier:
NCT03462342
Treatment
Recurrent ovarian cancer

Metastatic Pancreatic Cancer in US
Surveys, Registries, Interviews
People with metastatic pancreatic cancer and their caregivers

Treating Early-Stage BRCA, or PALB2-Associated Breast Cancer with a PARP Inhibitor (Niraparib) and Immunotherapy (Dostarlimab)
Clinicaltrials.gov identifier:
NCT04584255
Treatment
Early-stage breast cancer & a BRCA1, BRCA2 or PALB2 mutation

Investigational PARP Inhibitor AZD5305 Alone or in Combination With Other Anti-cancer Agents in Patients With Advanced Solid Tumors (PETRA)
Clinicaltrials.gov identifier:
NCT04644068
Treatment
Advanced ovarian, breast, prostate or pancreatic cancer

Interview about Hispanic/Latino Community Experiences Accessing Genetic Testing for Hereditary Cancer Risk
Surveys, Registries, Interviews
Hispanic/Latino people with a personal diagnosis of cancer or a family history of cancer

Targeted Therapy RP-3500 Alone or in Combination with Talazoparib or Gemcitabine in Advanced Solid Tumors with DNA Damage Repair Mutations (TRESR Study)
Clinicaltrials.gov identifier:
NCT04497116
Treatment
Advanced solid tumors

Screening for Cancer DNA in the Blood after Treatment for Early-Stage TNBC and/or a BRCA Mutation; Followed by Study Comparing Niraparib with Placebo for People with Cancer DNA found in their Blood (ZEST)
Clinicaltrials.gov identifier:
NCT04915755
Treatment
Early-stage TNBC or early-stage breast cancer with a BRCA mutation

ATR Inhibitor Plus Niraparib Study in Advanced Solid Tumors and Ovarian Cancer
Clinicaltrials.gov identifier:
NCT04267939
Treatment
Advanced ovarian cancer or other solid tumors

Survey: Making Decisions about Genetic Testing
Surveys, Registries, Interviews
Survey for adults who have had genetic testing for inherited cancer risk through a doctor

Adding Pembrolizumab to Olaparib to Treat Pancreatic Cancer in People with an Inherited BRCA Mutation
Clinicaltrials.gov identifier:
NCT04548752
Treatment
Metastatic pancreatic cancer and a BRCA1 or BRCA2 mutation

Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in People With MSI-High or dMMR Stage IV Colorectal Cancer
Clinicaltrials.gov identifier:
NCT04895722
Treatment
Stage 4 colorectal cancer

Studying Crowdfunding for Cancer
Surveys, Registries, Interviews
Cancer survivors who have used crowdfunding to help cover cancer-related costs

Tools To Be Fit: Tools to Improve Nutrition and Physical Activity for Colorectal Cancer Survivors
Clinicaltrials.gov identifier:
NCT05056077
Quality of Life
Nonmetastatic colon or rectal cancer

A Study of the Investigational Targeted Therapy ART4215 to Treat Advanced or Metastatic Solid Tumors
Clinicaltrials.gov identifier:
NCT04991480
Treatment
Advanced solid tumors

Investigating BRCA Previvors’ Utilization of Social Media for Health Decision Making and Social Support
Surveys, Registries, Interviews
Women with a BRCA1 or BRCA2 mutation who have never had cancer

Survey: How Willing are You to Participate in Different Types of Clinical Trials for the Prevention of Breast Cancer?
Surveys, Registries, Interviews

Retifanlimab Alone or with Other Agents for Advanced Endometrial Cancer that Progressed with Platinum
Clinicaltrials.gov identifier:
NCT04463771
Treatment
Advanced endometrial cancer

Testing a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation
Clinicaltrials.gov identifier:
NCT04367675
Prevention
People with a BRCA1 or BRCA2 mutation

Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects
Clinicaltrials.gov identifier:
NCT04030559
Treatment
High-risk localized prostate cancer

Treatment with ATR Inhibitor for Advanced or Metastatic Solid Tumors
Clinicaltrials.gov identifier:
NCT04657068
Treatment
Advanced solid tumors

Treating Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer with Chemotherapy and Rucaparib
Clinicaltrials.gov identifier:
NCT03337087
Treatment
Metastatic colorectal, pancreatic, gastroesophageal or biliary tract cancer

Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel for Recurrent or Primary Advanced Endometrial Cancer (RUBY)
Clinicaltrials.gov identifier:
NCT03981796
Treatment
Metastatic endometrial cancer

CYH33 in Combination With Olaparib in Patients With Advanced Solid Tumors and DNA Damage Repair Mutations
Clinicaltrials.gov identifier:
NCT04586335
Treatment
Advanced solid tumors

Nivolumab and Relatlimab in Advanced MSI-H Cancers Resistant to Prior PD-L1 Inhibitor
Clinicaltrials.gov identifier:
NCT03607890
Treatment
Solid tumors that are MSI-High and resistant to prior immunotherapy

Atorvastatin ± Aspirin for Colorectal Cancer Prevention for People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT04379999
Prevention

Olaparib, Palbociclib and Fulvestrant for BRCA-Associated, ER/PR-Positive, Her2-Negative Metastatic Breast Cancer
Clinicaltrials.gov identifier:
NCT03685331
Treatment



A Study to Compare Two Surgical Procedures in Women with BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer (SOROCk)
Clinicaltrials.gov identifier:
NCT04251052
Prevention

Treating Metastatic Pancreatic Cancer with an Inherited or Tumor BRCA1/2 or PALB2 Mutation with Niraparib and Dostarlimab
Clinicaltrials.gov identifier:
NCT04493060
Treatment

AMPLIFY: a new online weight loss study specifically for cancer survivors!
Clinicaltrials.gov identifier:
NCT04000880
Quality of Life

Developing a Test for the Detection of Ovarian Cancer
Clinicaltrials.gov identifier:
NCT04794322
Prevention

PROMISE Registry: A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness
Clinicaltrials.gov identifier:
NCT04995198
Surveys, Registries, Interviews

Treating Advanced Solid Tumors in People with Inherited PTEN Mutations Using the Investigational Drug TAS-117
Clinicaltrials.gov identifier:
NCT04770246
Treatment
People with advanced cancer and an inherited PTEN mutation

Chemotherapy, Bevacizumab, and/or Atezolizumab for dMMR / MSI-H Metastatic Colorectal Cancer (COMMIT Study)
Clinicaltrials.gov identifier:
NCT02997228
Treatment

TALAVE: Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer
Clinicaltrials.gov identifier:
NCT03964532
Treatment


Screening for Pancreatic Cancer in Patients with an Inherited BRCA1, BRCA2, PALB2 or ATM Mutation
Clinicaltrials.gov identifier:
NCT02478892
Prevention

Omega 3 Fatty Acids in Colorectal Cancer (CRC) Prevention in Patients With Lynch Syndrome (COLYNE)
Clinicaltrials.gov identifier:
NCT03831698
Prevention

Olaparib or Placebo in Patients with Surgically Removed Pancreatic Cancer who have a BRCA1, BRCA2 or PALB2 Mutation
Clinicaltrials.gov identifier:
NCT04858334
Treatment


Phase 1 Study of Oral Drug PMD-026 in People With Metastatic Breast Cancer and Metastatic Triple Negative Breast Cancer
Clinicaltrials.gov identifier:
NCT04115306
Treatment

Addition of Pembrolizumab to Radiation Treatment for Newly Diagnosed Early Stage MSI-High Endometrial Cancer
Clinicaltrials.gov identifier:
NCT04214067
Treatment

Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations
Clinicaltrials.gov identifier:
NCT04042831
Treatment


Nivolumab, Nivolumab Plus Ipilimumab, or Chemotherapy for Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (CheckMate 8HW)
Clinicaltrials.gov identifier:
NCT04008030
Treatment
People with metastatic colorectal cancer that is MSI-High

Pembrolizumab and Olaparib for Metastatic Pancreatic Cancer with Homologous Recombination Deficiency or Exceptional Response to Platinum Chemotherapy
Clinicaltrials.gov identifier:
NCT04666740
Treatment

PARP Inhibitor for Metastatic Prostate Cancer With DNA Repair Defects
Clinicaltrials.gov identifier:
NCT03012321
Treatment

Mobile Mindfulness Meditation Intervention to Improve Neuropathy in Cancer Survivors
Clinicaltrials.gov identifier:
NCT03581357
Quality of Life

Parenting Adolescent-Aged Children While Managing a Parental Cancer Diagnosis – Share Your Story
Surveys, Registries, Interviews

Mobile Mindfulness Meditation Intervention for Cancer Survivors
Clinicaltrials.gov identifier:
NCT03581357
Quality of Life

A Survey on Options for Managing Cancer Risk Among Women with a BRCA1 or BRCA2 Mutation
Surveys, Registries, Interviews

Olaparib Expanded - Treating Metastatic Breast Cancer in People without gBRCA Mutations
Clinicaltrials.gov identifier:
NCT03344965
Treatment

The Risk Factor Analysis of Hereditary Breast and Ovarian Cancer In Women with BRCA1, BRCA2 or PALB2 Mutations
Surveys, Registries, Interviews

Diagnosis of Breast Cancer in Young Women - Share Your Story
Surveys, Registries, Interviews

Talazoparib for people with metastatic breast cancer who have acquired (somatic) BRCA mutations
Clinicaltrials.gov identifier:
NCT03990896
Treatment

A Study of Nivolumab in Selected Uterine Cancer Patients
Clinicaltrials.gov identifier:
NCT03241745
Treatment


Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair
Clinicaltrials.gov identifier:
NCT02912559
Treatment

Genetic Testing for Men with Metastatic Prostate Cancer (GENTleMEN Study)
Clinicaltrials.gov identifier:
NCT03503097
Treatment


Decision Navigation for Advanced Prostate Cancer Treatment Options Using mHealth
Clinicaltrials.gov identifier:
NCT03327103
Quality of Life

Pancreatic Cancer Screening Study for High Risk People
Clinicaltrials.gov identifier:
NCT03250078
Prevention

Denosumab and Mammographic Density in Premenopausal Women With Dense Breasts (TRIDENT)
Clinicaltrials.gov identifier:
NCT04067726
Prevention


Study of Safety and Effectiveness of Motiva® Breast Implants
Clinicaltrials.gov identifier:
NCT03579901
Quality of Life

Study for People with Unexpected Genetic Results
Clinicaltrials.gov identifier:
NCT02595957
Prevention
.jpg?h=300&w=400&fit=contain)
Talking to Employers and Medical Staff About Breast Cancer Treatment and Your Job
Clinicaltrials.gov identifier:
NCT03572374
Quality of Life



INTERVAL: INTense Exercise foR surVivAL in Men With Metastatic Prostate Cancer
Clinicaltrials.gov identifier:
NCT02730338
Quality of Life

RADCOMP: A Study at the Heart of Breast Cancer Treatment
Clinicaltrials.gov identifier:
NCT02603341
Treatment

Identification and Analysis of Families With Genetic Susceptibility To Cancer Registry
Surveys, Registries, Interviews


.jpeg?h=300&w=400&fit=contain)


Sponsored By:
This resource was made possible through an independent grant from Merck & Co., Inc.