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Cancer risk associated with inherited  mutations

If you have tested positive for an  mutation, we recommend speaking with a genetics expert who can look at your personal and family history of cancer, and can help you decide on a plan to manage your risk. Note that when we use "men" and "women" we are referring to the sex you were assigned at birth.

Risk for cancer in people with an mutation. Source: NCCN: Genetic/Familiar High-Risk Assessment: Colorectal Version 1.2021
Cancer type Lifetime risk with for people with mutation Lifetime risk for people in general population Average age of diagnosis for people with mutation Average age of diagnosis for people in the general population
Colorectal 33 - 52% 4.2% 44 years 68 - 72 years
Endometrial 21 - 57% 3.1% 47 - 48 years 60 years
Ovarian 8 - 38% 1.3% 43 years 63 years
Kidney/ureter 2.2 - 28% unknown 54 - 61 years Not specified
Bladder 4.4 - 12.8% 2.4% 59 years 73 years
Gastric  0.2 - 9% 0.9% 52 years 68 years
Small bowel 1.1 - 10% 0.3% 48 years 60s - 70s
3.9 - 23.8% 11.6% 59 - 63 years 66 years
Brain  2.5 - 7.7% 0.6% No data 59 years
Biliary tract .02 - 1.7% 0.2% 57 years 70 - 72 year

People with an inherited  mutation may have an increased risk for other cancers. The exact risks for the following cancers are unknown:

  • pancreatic cancer
  • sebaceous skin growths
  • female breast cancer

Research on how inherited mutations in the  gene affect cancer risk is ongoing.

   Graph of lifetime risk for colorectal cancer in person with an EPCAM mutation  Graph of lifetime risk for endometrial cancer with an EPCAM mutation

   Graph of lifetime ovarian risk for people with an EPCAM mutation  Graph of lifetime risk for bladder cancer in person with EPCAM mutation

Graph of lifetime prostate cancer risk in men with EPCAM mutation Graph of lifetime risk for kidney or ureteral cancer in person with EPCAM mutation

It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years will vary depending on:

  • current age
  • sex assigned at birth
  • specific mutation
  • personal and family health history
  • diet, exercise, lifestyle and other factors
Last updated February 27, 2023

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FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022