Hereditary Cancer and Genetic Testing

Cancer risk associated with inherited BARD1 mutations

If you have tested positive for an BARD1 mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you choose the best plan for managing your cancer risk.

  • Women with a BARD1 mutation have an increased risk of breast cancer, including triple-negative breast cancer. The estimated lifetime risk of breast cancer is as high as 40 percent.  
  • Currently, evidence is insufficient to conclusively show that a BARD1 mutation is associated with an increased risk of other cancers.

Research on the risk for cancer in people with BARD1 mutations is ongoing. 

Graph of lifetime risk for breast cancer in a woman with a <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-bard1'
                title='<p>BARD1 is a gene found on chromosome 2.&nbsp;Mutations in BARD1&nbsp;increase the risk for&nbsp;female breast cancer&nbsp;and possibly other cancers.&nbsp;</p>
'
            >BARD1</abbr> mutation

Last updated August 31, 2021