BARD1 Mutations: Cancer Risk

Cancer Risk Associated with Inherited BARD1 Mutations

If you have tested positive for a BARD1 mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you choose the best plan for managing your cancer risk. 

Experts at the National Comprehensive Cancer Network (NCCN) created guidelines which estimate the cancer risks for people with BARD1 mutations. These cancer risk estimates are updated based on the latest research.  

• Women with a BARD1 mutation have an increased risk of breast cancer. The estimated lifetime risk of breast cancer is 17 - 30 percent.  
• Currently, there is not enough evidence to show a link between BARD1 mutations and an increased risk of other cancers.

It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years will vary depending on:

• current age
• gender
• specific mutation
• personal and family health history
• diet, exercise, lifestyle and other factors

Research on the risk for cancer in people with BARD1 mutations is ongoing.