Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.

Cancer risk associated with inherited MSH6 mutations

If you have tested positive for an MSH6 mutation, we recommend speaking with a genetics expert who can look at your personal and family history of cancer, and can help you decide on the best risk management plan.

Risk for cancer in people with an MSH6 mutation. Source: NCCN: Genetic/Familiar High-Risk Assessment: Colorectal Version 1.2020
Cancer type Lifetime risk with for people with MSH6 mutation Lifetime risk for people in general population Average age of diagnosis for people with MSH6 mutation Average age of diagnosis for people in the general population
Colorectal 10 - 44% 4.2% 42-69 years 68 - 72 years
Endometrial 16 - 49% 3.1% 53 - 55 years 60 years
Ovarian <1 - 13% 1.3% 46 years 63 years
Kidney/ureter .7 - 5.5% 1.2% 54 - 61 years Not specified
Bladder 1 - 8.2% 2.4% 71 years 73 years
Gastric  <1 - 7.9% 0.9% 52 years 68 years
Small bowel <1 - 4% 0.3% 48 years 60s - 70s
Brain  .8 - 1.8% 0.6% No data 59 years

People with an inherited MSH6 mutation may have an increased risk for other cancers. The exact risks for the following cancers are unknown:

  • biliary tract cancer
  • female breast cancer
  • pancreatic cancer
  • sebaceous skin growths

Research on how inherited mutations in the MSH6 gene affect cancer risk is ongoing.

  Lifetime colorectal cancer risk for people with <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-msh6'
                title='<p>MSH6&nbsp;is a gene found on chromosome 2.&nbsp;Mutations in MSH6&nbsp;are associated with Lynch Syndrome. People with Lynch Syndrome have an&nbsp;increased the risk for&nbsp;colon, uterine, ovarian, pancreatic and other cancers.</p>

<p>Also see Lynch Syndrome.</p>
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            >MSH6</abbr> mutations    

clinical-trials
  • NCT00508573: Registry for Women Who Are At Risk Or May Have Lynch Syndrome. The goal of this study is to create a registry of information about women who have or are at risk for Lynch syndrome, in order to study gynecologic cancer risks.
  • The HEROIC Registry allows people with Lynch syndrome to contribute medical information and their experiences living with Lynch Syndrome and its associated cancers to help researchers develop new treatments, understand the various Lynch genetic mutations, and conduct further studies and clinical trials. The registry is maintained by the nonprofit organization AliveAndKickn.