Endometrial Cancer Risk Management & Treatment

Learn about options for endometrial cancer screening, prevention and treatment

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Endometrial Cancer

Endometrial Cancer Risk

What is endometrial cancer?

Endometrial cancer is a type of cancer that affects the lining of the uterus (called the endometrium). 

Who is at risk for endometrial cancer?  

Every woman is at risk for endometrial cancer; the risk varies based on multiple factors, including:

  • age
  • presence of an inherited mutation
  • personal and family history of cancer
  • other risk factors:

Note that when we use "woman" we are referring to the sex assigned at birth.

Can endometrial cancer be hereditary?

About 5-15% of people with endometrial cancer have an inherited mutation linked to cancer risk. Genetic counseling and testing can help people learn if they are at high risk for endometrial cancer. Inherited mutations in the genes listed below increase the risk for endometrial cancer and can cause cancer to run in families.

Genes Linked to Endometrial Cancer Risk

Uterine serous carcinoma is a rare type of endometrial cancer that has been linked to inherited BRCA1 and BRCA2 mutations. Researchers are studying other inherited mutations that may increase the risk of endometrial cancer.

What else affects endometrial cancer risk?

Diet, weight, exercise, hormone exposure, and medications like tamoxifen can affect endometrial cancer risk in the general population and in people at high risk for cancer. Researchers are studying how much these factors influence risk in people with inherited mutations.

Risk Management and Treatment

Risk management 

People at high risk should know the symptoms of endometrial cancer. There are options for managing endometrial cancer risk, including screening, medications to reduce risk and surgery to reduce risk. National expert guidelines for endometrial cancer risk management are based on your gene mutation and on your level of risk. Click on the button below to learn more about these guidelines. Speak with your healthcare provider to decide on a risk-management plan and schedule that is right for you.


People diagnosed with endometrial cancer may have different treatment options based on the results of genetic testing and biomarker testing. Click on the button below to learn more about these treatment options. Speak with your healthcare provider to decide on a treatment plan that is right for you.

Last updated June 29, 2024