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Hereditary Cancer and Genetic Testing

Cancer risk associated with an inherited  mutation

If you have tested positive for a  mutation, we recommend consulting with a genetics expert who can assess your personal and family history of cancer and can help you determine the best risk management plan.
 

Risk for women

  • Women with a mutation have about a 10-15 percent lifetime risk for ovarian cancer.
  • Women with a mutation have about a 20-40 percent lifetime risk for breast cancer with a tendency for 


Risk for men

  • Currently there is no evidence of increased cancer risk in men with a mutation. 

 

Graph of lifetime risk for ovarian cancer in women with <button
                x-data
                class='glossary-tip tt-rad51c'
                x-tooltip='<p>RAD51C is a gene found on chromosome 17.&nbsp;Women who inherit one mutated copy of RAD51C&nbsp;are at an increased risk of&nbsp;ovarian cancer.&nbsp;Ongoing research is studying the extent of that risk, and whether or not inheriting a RAD51C mutation increases a person’s risk for other types cancers.</p>

<p>Inheriting two mutated copies of RAD51C, one from each parent, has been shown to cause a rare blood disease known as Fanconi anemia in children. &nbsp;</p>
'
            >RAD51C</button> mutation     Graph of lifetime risk range for breast cancer in women with a <button
                x-data
                class='glossary-tip tt-rad51c'
                x-tooltip='<p>RAD51C is a gene found on chromosome 17.&nbsp;Women who inherit one mutated copy of RAD51C&nbsp;are at an increased risk of&nbsp;ovarian cancer.&nbsp;Ongoing research is studying the extent of that risk, and whether or not inheriting a RAD51C mutation increases a person’s risk for other types cancers.</p>

<p>Inheriting two mutated copies of RAD51C, one from each parent, has been shown to cause a rare blood disease known as Fanconi anemia in children. &nbsp;</p>
'
            >RAD51C</button> mutation

It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years will vary depending on:

  • current age
  • gender assigned at birth
  • specific mutation
  • personal and family health history
  • diet, exercise, lifestyle and other factors
Last updated September 22, 2022

Get Support
Get Support

FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022

Open Clinical Trials
Open Clinical Trials

The following are risk-management studies enrolling people with inherited mutations. Check study listings or contact the study team to see if you are eligible. 

Multiple cancers

cancer

  • NCT03805919: Men at High Genetic Risk for  Cancer. This is a  cancer screening study using  in high risk men. This study is open to men with , , , , , HOXB13, , , ,  and other inherited mutations.
  • NCT05129605: Cancer Genetic Risk Evaluation and Screening Study (PROGRESS).  This study will look at how well  MRI works as a screening tool for men at high risk for cancer. This study is open to men with inherited mutations in , , , , , , HOXB13, , , , , , , , , and other genes. 

Ovarian cancer

Pancreatic cancer

Additional risk-management clinical trials for people with inherited mutations may be found here.

updated: 09/11/2022