Hereditary Cancer and Genetic Testing

Cancer risk associated with an inherited RAD51C mutation

If you have tested positive for a RAD51C mutation, we recommend consulting with a genetics expert who can assess your personal and family history of cancer and can help you determine the best risk management plan.
 

Risk for women

  • Women with a RAD51C mutation have about a 10 percent lifetime risk for ovarian cancer.
  • Women with a RAD51C mutation have about a 15-40 percent lifetime risk for breast cancer with a tendency for triple-negative breast cancer


Risk for men

  • Currently there is no evidence of increased cancer risk in men with a RAD51C mutation. 

 

Graph of lifetime risk for ovarian cancer in women with <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-rad51c'
                title='<p>RAD51C is a gene found on chromosome 17.&nbsp;Women who inherit one mutated copy of RAD51C&nbsp;are at an increased risk of&nbsp;ovarian cancer.&nbsp;Ongoing research is studying the extent of that risk, and whether or not inheriting a RAD51C mutation increases a person’s risk for other types cancers.</p>

<p>Inheriting two mutated copies of RAD51C, one from each parent, has been shown to cause a rare blood disease known as Fanconi anemia in children. &nbsp;</p>
'
            >RAD51C</abbr> mutation     Graph of lifetime risk range for breast cancer in women with a <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-rad51c'
                title='<p>RAD51C is a gene found on chromosome 17.&nbsp;Women who inherit one mutated copy of RAD51C&nbsp;are at an increased risk of&nbsp;ovarian cancer.&nbsp;Ongoing research is studying the extent of that risk, and whether or not inheriting a RAD51C mutation increases a person’s risk for other types cancers.</p>

<p>Inheriting two mutated copies of RAD51C, one from each parent, has been shown to cause a rare blood disease known as Fanconi anemia in children. &nbsp;</p>
'
            >RAD51C</abbr> mutation

Last updated September 22, 2021