Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.
I am here to learn about:

Genetic Testing

Women with Mutations

Lynch Syndrome

Biomarker Testing

I've Tested Positive, Now What?

Genetics and Pancreatic Cancer

Men with Mutations

Managing Menopause

Genetics and Prostate Cancer

Genetics and Ovarian Cancer

Genetics and Endometrial Cancer

Genetics and Colorectal Cancer

Information for Healthcare Professionals

Information for Researchers

Genetics and Breast Cancer

Hereditary Cancer and Genetic Testing

Hereditary Cancer Genes and Risk > By Gene Mutation > RAD51C > Cancer Risk

1
Overview
2
Cancer Risk
3
Risk Management
4
Cancer Treatment
5
Other Considerations

Cancer risk associated with an inherited RAD51C mutation

If you have tested positive for a RAD51C mutation, we recommend consulting with a genetics expert who can assess your personal and family history of cancer and can help you determine the best risk management plan.
 

Risk for women

  • Women with a RAD51C mutation have about a 10 percent lifetime risk for ovarian cancer.
  • Women with a RAD51C mutation have about a 15-40 percent lifetime risk for breast cancer with a tendency for triple-negative breast cancer. 


Risk for men

  • Currently there is no evidence of increased cancer risk in men with a RAD51C mutation. 

 

Graph of lifetime risk for ovarian cancer in women with <abbr data-toggle='tooltip' class='glossary-tip tt-rad51c' title='<p>RAD51C is a gene found on chromosome 17.&nbsp;Women who inherit one mutated copy of RAD51C&nbsp;are at an increased risk of&nbsp;ovarian cancer.&nbsp;Ongoing research is studying the extent of that risk, and whether or not inheriting a RAD51C mutation increases a person’s risk for other types cancers.</p> <p>Inheriting two mutated copies of RAD51C, one from each parent, has been shown to cause a rare blood disease known as Fanconi anemia in children. &nbsp;</p> ' >RAD51C</abbr> mutation     Graph of lifetime risk range for breast cancer in women with a <abbr data-toggle='tooltip' class='glossary-tip tt-rad51c' title='<p>RAD51C is a gene found on chromosome 17.&nbsp;Women who inherit one mutated copy of RAD51C&nbsp;are at an increased risk of&nbsp;ovarian cancer.&nbsp;Ongoing research is studying the extent of that risk, and whether or not inheriting a RAD51C mutation increases a person’s risk for other types cancers.</p> <p>Inheriting two mutated copies of RAD51C, one from each parent, has been shown to cause a rare blood disease known as Fanconi anemia in children. &nbsp;</p> ' >RAD51C</abbr> mutation

Last updated September 22, 2021