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Hereditary Cancer and Genetic Testing

Cancer risk associated with inherited  mutations

If you have tested positive for an inherited mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you choose the best plan for managing your cancer risk.


Risks for women

Women who have a gene mutation have an increased risk of developing a specific type of breast cancer called lobular breast cancer. The estimated lifetime risk in a woman with a mutation is 40-60 percent. 


Risks for any gender

Gastric cancer: Men and women who have an inherited mutation have an increased risk of developing a specific type of stomach (gastric) cancer called diffuse gastric cancer. 

  • lifetime risk for gastric cancer is 67 percent for men and 83 percent for women. This compares to less than 1 percent in the general population.
  • average age of diagnosis is 37 compared to 68 in the general population. 

Some research has suggested that mutations may increase the risk for other cancers. However, these studies are not conclusive and lifetime risks for these cancers are not clearly defined. For this reason, genetics experts often look at family history of cancer to help people with mutations understand their risk for additional cancers. Research on and other cancer risk is ongoing.

Graph of lifetime risk for stomach cancer in women with a <button
                x-data
                class='glossary-tip tt-cdh1'
                x-tooltip='<p>CDH1 is the name of a gene that has been&nbsp;associated with hereditary diffuse gastric cancer syndrome. Mutations in CDH1 increase&nbsp;the risk of stomach cancer and breast cancer in women. CDH1 stands for "Cadherin-1."</p>
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            >CDH1</button> mutation     Graph of lifetime risk of stomach cancer in man with a <button
                x-data
                class='glossary-tip tt-cdh1'
                x-tooltip='<p>CDH1 is the name of a gene that has been&nbsp;associated with hereditary diffuse gastric cancer syndrome. Mutations in CDH1 increase&nbsp;the risk of stomach cancer and breast cancer in women. CDH1 stands for "Cadherin-1."</p>
'
            >CDH1</button> mutation

Graph of lifetime risk for breast cancer in woman with a <button
                x-data
                class='glossary-tip tt-cdh1'
                x-tooltip='<p>CDH1 is the name of a gene that has been&nbsp;associated with hereditary diffuse gastric cancer syndrome. Mutations in CDH1 increase&nbsp;the risk of stomach cancer and breast cancer in women. CDH1 stands for "Cadherin-1."</p>
'
            >CDH1</button> mutation

 

find-support find-support

FORCE offers many peer support programs for people with inherited mutations. 

updated: 03/12/2022

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NCT02665195: Registry Of MultiPlex Testing (PROMPT). PROMPT is an online research registry. The goal of PROMPT is to help researchers to better understand the risks that are linked to mutations in less well-studied genes. People with inherited mutations can enroll in PROMPT to help researchers learn more about cancer risks. 

updated: 02/05/2022

clinical-trials clinical-trials

updated: 03/13/2022

Last updated March 13, 2022