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Cancer Treatment
Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.

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Glossary on

Cancer Treatment for People with Mutations

People with an inherited mutation who have been diagnosed with cancer may have different treatment options than people without a mutation. To learn more about standard of care treatment options for specific types of cancer, visit our section on Cancer Treatment by Cancer Type

If you have an inherited mutation, have been diagnosed with cancer and the situations below apply to you, you may wish to speak to your doctor about your medical options.

Regardless of cancer type, people with a mutation may benefit from testing and may qualify for clinical trials looking for more effective treatments for cancer.

Note that when we use "men" and "women" we are referring to the sex you were assigned at birth.

Surgical decisions for women diagnosed with breast cancer

Because of the increased risk for a second breast cancer diagnosis, women who are diagnosed with breast cancer who test positive for an in may choose  mastectomy rather than and radiation. Mutation carriers who undergo mastectomy are less likely to develop a second breast cancer. 

The Truqap (capivasertib) is a type of drug known as an AKT inhibitor. AKT inhibitors may work better in people with mutations.

or advanced breast cancer

Truqap combined with fulvestrant is approved to treat , advanced or breast cancer with a mutation in , PIK3 or AKT1 genes which recurred or got worse after standard hormone  therapy. 

Other types of advanced or cancers

Although not approved for other types of cancer, AKT inhibitors are being studied in other types of cancer, including advanced endometrial cancer. If you have advanced cancer for which there is no approved treatment yet, you may want to speak with their doctor about using Truqap "off-label" or look for a clinical trial using an AKT inhibitor.  

Get Support
Get Support

FORCE offers many peer support programs for people with inherited mutations. 

Paying For Care
Paying For Care

Paying for cancer treatment

The majority of public and private health insurance plans are required to cover cancer diagnosis and treatment; copays, coinsurance and deductibles often apply. Patient costs and coverage for specific doctors, facilities or treatments may vary based on your health plan. Visit our section on Insurance and Paying for Care: Treatment  for more information, links to sample appeal letters and other resources. 

If you need information about finding an insurance plan, watch our video: Choosing Wisely: How to Pick Insurance Plans.

Some pharmaceutical companies have assistance programs that help cover the cost for their medications: 

Organizations that offer co-pay assistance:

Other resources:

  • The American Cancer Society provides information and resources on covering the cost of cancer care. Public assistance, such as Medicaid may be available if you are ineligible for other programs. 
  • Needy Meds: Assistance programs to help patients with cost of medications and other healthcare.
  • Triage Cancer offers tools and resources to help individuals cope with the financial aspects of a cancer diagnosis.

Open Clinical Trials
Open Clinical Trials

The following are studies enrolling people with inherited mutations.  

Last updated January 02, 2024