Hereditary Cancer and Genetic Testing

Cancer treatment for people with inherited CDK4 mutations

Currently there are no cancer treatments approved specifically for people with a CDK4 mutation, nor guidelines for treating cancer written specifically for people with a CDK4 mutation. Consider participating in a clinical trial to help experts learn which treatments work best for someone with an inherited CDK4 mutation. 

To learn more about standard of care treatment options for specific types of cancer, visit our section on Cancer Treatment by Cancer Type


If you are a person with a CDKN2A mutation, you can find peer support through the following resources:

Other organizations that provide support for people diagnosed with melanoma include:

  • AIM at Melanoma is a nonprofit organization that has online support and a list of in-person support groups by region. 

The majority of public and private health insurance plans are required to cover cancer diagnosis and treatment; copays, coinsurance and deductibles often apply. Patient costs and coverage for specific doctors, facilities or treatments may vary based on your health plan. If your insurance company denies your claim, your health care provider can help you write an appeal letter, or you can use one of our sample appeal letters. Visit our section on Insurance and Paying for Care: Treatment for more information.


The following clinical trials may be enrolling people with a CDK4 inherited mutation who have been diagnosed with cancer.

Last updated July 28, 2020