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Hereditary Cancer and Genetic Testing

Cancer risk associated with an inherited mutation

If you have tested positive for a  mutation, we recommend consulting with a genetics expert who can assess your personal and family history of cancer and can help you determine the best risk management plan.
 

Risk for women

  • Women with a  mutation have about a 10 percent lifetime risk for ovarian cancer.
  • Women with a  mutation have about a 15-40 percent lifetime risk for breast cancer with a tendency for 


Risk for men

  • Currently there is no evidence of increased cancer risk in men with a  mutation. 

 

Graph of lifetime risk for ovarian cancer in a woman with a <button
                x-data
                class='glossary-tip tt-rad51d'
                x-tooltip='<p>RAD51D is a gene found on chromosome 17.&nbsp;Several studies have suggested that mutations in the RAD51D gene increase a woman’s risk of ovarian cancer, and possibly breast cancer as well.&nbsp;Ongoing research is exploring the extent of that risk, and whether or not a RAD51D mutation increases a person’s risk for other types of cancers.</p>
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            >RAD51D</button> mutation     Graph of lifetime risk for breast cancer in a woman with a <button
                x-data
                class='glossary-tip tt-rad51d'
                x-tooltip='<p>RAD51D is a gene found on chromosome 17.&nbsp;Several studies have suggested that mutations in the RAD51D gene increase a woman’s risk of ovarian cancer, and possibly breast cancer as well.&nbsp;Ongoing research is exploring the extent of that risk, and whether or not a RAD51D mutation increases a person’s risk for other types of cancers.</p>
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            >RAD51D</button> mutation

find-support find-support

FORCE offers many peer support programs for people with inherited mutations. 

updated: 03/12/2022

clinical-trials clinical-trials

NCT02665195: Registry Of MultiPlex Testing (PROMPT). PROMPT is an online research registry. The goal of PROMPT is to help researchers to better understand the risks that are linked to mutations in less well-studied genes. People with inherited mutations can enroll in PROMPT to help researchers learn more about cancer risks. 

updated: 02/05/2022

Last updated March 17, 2022