Hereditary Cancer and Genetic Testing

Cancer risk associated with an inherited RAD51D mutation

If you have tested positive for a RAD51D mutation, we recommend consulting with a genetics expert who can assess your personal and family history of cancer and can help you determine the best risk management plan.
 

Risk for women

  • Women with a RAD51D mutation have about a 10 percent lifetime risk for ovarian cancer.
  • Women with a RAD51D mutation have about a 15-40 percent lifetime risk for breast cancer with a tendency for triple-negative breast cancer


Risk for men

  • Currently there is no evidence of increased cancer risk in men with a RAD51D mutation. 

 

Graph of lifetime risk for ovarian cancer in a woman with a <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-rad51d'
                title='<p>RAD51D is a gene found on chromosome 17.&nbsp;Several studies have suggested that mutations in the RAD51D gene increase a woman’s risk of ovarian cancer, and possibly breast cancer as well.&nbsp;Ongoing research is exploring the extent of that risk, and whether or not a RAD51D mutation increases a person’s risk for other types of cancers.</p>
'
            >RAD51D</abbr> mutation     Graph of lifetime risk for breast cancer in a woman with a <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-rad51d'
                title='<p>RAD51D is a gene found on chromosome 17.&nbsp;Several studies have suggested that mutations in the RAD51D gene increase a woman’s risk of ovarian cancer, and possibly breast cancer as well.&nbsp;Ongoing research is exploring the extent of that risk, and whether or not a RAD51D mutation increases a person’s risk for other types of cancers.</p>
'
            >RAD51D</abbr> mutation

Last updated September 23, 2021