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Cancer risk associated with an inherited mutation

If you have tested positive for a mutation, we recommend that you consult with a genetics expert who can assess your personal and family history of cancer and can help you decide on a plan to manage your risk. Note that when we use the term "men" and "women" we are referring to the sex you were assigned at birth.

People with a mutation are at increased risk for many cancers. The following are the risks for the most common cancers in people with Li-Fraumeni syndrome:

Risks for adults

Cancer type Risk with a  mutation Average- risk person
Breast cancer in women more than 60%  12.5% 
Soft tissue sarcoma in men 22%  less than 1%
Soft tissue sarcoma in women 15% less than 1%
Bone sarcoma in men 11% less than 1%
Bone sarcoma in women 5% less than 1%
Brain cancer in men 19% less than 1%
Brain cancer in women 6% less than 1%
Colorectal cancer 20% 4%
Pancreatic cancer 5% 1.5%


Risks for children

Many of the cancers seen in occur particularly early in life, including in children and young adults.4% of babies will develop cancer in their first year of life

  • 22% will develop cancer by age 5
  • 41% of children will develop cancer by age 18

Research has shown that plays a role in many childhood cancers, including:

  • 80% of rhabdomyosarcoma with diffuse anaplasia
  • 50% of childhood adrenocortical carcinoma  
  • 40% of choroid plexus carcinoma
  • 40% of low-hypodiploid acute lymphoblastic leukemia
  • 10% of Sonic Hedgehog subtype medulloblastoma
  • 10% of childhood osteosarcoma 
Last updated January 02, 2024

Get Support
Get Support

FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022