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STK11 (Peutz–Jeghers Syndrome): Cancer Risks
People with an inherited mutation in the STK11 gene have an increased risk for certain types of cancer. Learn about these risks. Stay up to date by signing up for our community newsletter.
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Cancer Risk Associated with Inherited Mutations
If you have tested positive for an mutation, we recommend speaking with a genetics expert who can look at your personal and family history of cancer, and can help you decide on a plan for managing your risk. Note that when we use "women" we are referring to people assigned female at birth.
cancer risks include the following:
Cancer Type |
Lifetime Risk with STK11 Mutation |
Lifetime Risk in General Population |
Breast cancer in women (people assigned female at birth) |
32 - 54% |
12.5% |
Colorectal |
39% |
4.1% |
Gastric |
29% |
0.8% |
Ovarian sex cord tumors (may be cancer or benign) |
20% or higher |
1.1% |
Pancreatic |
11 - 36% |
1.5% |
Gastric |
5 - 7% |
0.8% |
Small bowel |
13% |
0.3% |
Lung |
7 - 17% |
6% |
Cervical cancer |
10% or higher |
No data |
Endometrial |
9% |
3.1% |
Testicular (Sertoli cell tumor) |
9% |
Less than 1% |
Source: NCCN: Genetic/Familiar High-Risk Assessment: Colorectal, Endometrial, Gastric Version 1.2024. |
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It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years will vary depending on:
- current age
- sex assigned at birth
- specific mutation
- personal and family health history
- diet, exercise, lifestyle and other factors
Last updated January 02, 2024