Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.

Cancer risk associated with an inherited STK11 mutation

If you have tested positive for a STK11 mutation, we recommend consulting with a genetics expert who can assess your personal and family history of cancer, and can help you determine the best risk management plan.

People with an inherited STK11 have a greatly increased risk of developing several types of cancer.


Risks for women

Women who have an inherited mutation in STK11 have an increased lifetime risk for these cancers:

  • Breast cancer: The lifetime risk for a women with a STK11 mutation is about 32 - 54 percent compared to 12.5 percent for an average risk woman. 
  • Ovarian cancer: The lifetime risk for a women with a STK11 mutation is about 18 - 21 (especially a rare type called a Sertoli cell tumor) compared to 1.3 percent for an average risk woman. 
  • Endometrial cancer: The lifetime risk for a women with a STK11 mutation is about 9 percent compared to 3 percent for an average risk woman. 
  • Cervical cancer: The lifetime risk for a women with a STK11 mutation is about 10 percent compared to less than 1 percent for an average risk woman. 


Risks for men

Men who have a mutation in STK11 have about a 9% lifetime risk of developing a rare type of testicular cancer called a Sertoli cell tumor compared to less than 1% for men in the general population.

Risks for men and women

Men and women who have a mutation in STK11 are at increased risk of developing these cancers. 

  • Colorectal cancer: The lifetime risk for people with an STK11 mutation is about 39 percent compared to 4 percent for an average risk person. 
  • Pancreatic cancer: The lifetime risk is 11 - 36 percent compared to 1.5 percent for an average risk person. 
  • Stomach (gastric) cancer: The lifetime risk is 29 percent compared to less than 1 percent for the average risk person.
  • Small intestine cancer: The lifetime risk is 13 percent compared to less than 1 percent for the average risk person.
  • Lung cancer: The lifetime risk is 7 - 17 percent. 

Graph of lifetime risk for breast cancer in women with an <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-stk11'
                title='<p>STK11 is a gene found on chromosome 19.&nbsp;Mutations in STK11 are associated with Peutz-Jeghers syndrome, a rare disorder that leads to increased risk of noncancerous growths and increased risk of certain cancers.&nbsp;</p>

<p>People with STK11 mutations are at a greatly increased risk of:</p>

<p>breast cancer in women (up to 50% lifetime risk)<br />
colon cancer (up to 39% lifetime risk)<br />
pancreatic cancer (up to 36% lifetime risk)<br />
stomach cancer (up to 29% lifetime risk)<br />
ovarian cancer (up to 21% lifetime risk)<br />
lung cancer (up to 17% lifetime risk)<br />
small intestine cancer (up to 13% lifetime risk)<br />
cervical cancer (up to 10% lifetime risk)<br />
uterine cancer (up to 9% lifetime risk)</p>

<p>See also Peutz-Jeghers Syndrome&nbsp;</p>
'
            >STK11</abbr> mutation     Graph of lifetime ovarian cancer risk in women with an <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-stk11'
                title='<p>STK11 is a gene found on chromosome 19.&nbsp;Mutations in STK11 are associated with Peutz-Jeghers syndrome, a rare disorder that leads to increased risk of noncancerous growths and increased risk of certain cancers.&nbsp;</p>

<p>People with STK11 mutations are at a greatly increased risk of:</p>

<p>breast cancer in women (up to 50% lifetime risk)<br />
colon cancer (up to 39% lifetime risk)<br />
pancreatic cancer (up to 36% lifetime risk)<br />
stomach cancer (up to 29% lifetime risk)<br />
ovarian cancer (up to 21% lifetime risk)<br />
lung cancer (up to 17% lifetime risk)<br />
small intestine cancer (up to 13% lifetime risk)<br />
cervical cancer (up to 10% lifetime risk)<br />
uterine cancer (up to 9% lifetime risk)</p>

<p>See also Peutz-Jeghers Syndrome&nbsp;</p>
'
            >STK11</abbr> mutation

Graph of lifetime risk for colorectal cancer in people with an <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-stk11'
                title='<p>STK11 is a gene found on chromosome 19.&nbsp;Mutations in STK11 are associated with Peutz-Jeghers syndrome, a rare disorder that leads to increased risk of noncancerous growths and increased risk of certain cancers.&nbsp;</p>

<p>People with STK11 mutations are at a greatly increased risk of:</p>

<p>breast cancer in women (up to 50% lifetime risk)<br />
colon cancer (up to 39% lifetime risk)<br />
pancreatic cancer (up to 36% lifetime risk)<br />
stomach cancer (up to 29% lifetime risk)<br />
ovarian cancer (up to 21% lifetime risk)<br />
lung cancer (up to 17% lifetime risk)<br />
small intestine cancer (up to 13% lifetime risk)<br />
cervical cancer (up to 10% lifetime risk)<br />
uterine cancer (up to 9% lifetime risk)</p>

<p>See also Peutz-Jeghers Syndrome&nbsp;</p>
'
            >STK11</abbr> mutation     Lifetime risk for pancreatic cancer in people with an <abbr
                data-toggle='tooltip'
                class='glossary-tip tt-stk11'
                title='<p>STK11 is a gene found on chromosome 19.&nbsp;Mutations in STK11 are associated with Peutz-Jeghers syndrome, a rare disorder that leads to increased risk of noncancerous growths and increased risk of certain cancers.&nbsp;</p>

<p>People with STK11 mutations are at a greatly increased risk of:</p>

<p>breast cancer in women (up to 50% lifetime risk)<br />
colon cancer (up to 39% lifetime risk)<br />
pancreatic cancer (up to 36% lifetime risk)<br />
stomach cancer (up to 29% lifetime risk)<br />
ovarian cancer (up to 21% lifetime risk)<br />
lung cancer (up to 17% lifetime risk)<br />
small intestine cancer (up to 13% lifetime risk)<br />
cervical cancer (up to 10% lifetime risk)<br />
uterine cancer (up to 9% lifetime risk)</p>

<p>See also Peutz-Jeghers Syndrome&nbsp;</p>
'
            >STK11</abbr> mutation

clinical-trials