TP53: Cancer Treatment

Radiation therapy concerns

Experts recommend that people with an inherited TP53 mutation minimize their radiation exposure, which increases the risk of a new cancer diagnosis. This includes avoiding radiation therapy for cancer treatment whenever possible.

Surgical considerations for people diagnosed with breast cancer

People with Li-Fraumeni syndrome have an increased risk for a second breast cancer diagnosis. Women who are diagnosed with early-stage breast cancer who test positive for a TP53 mutation may choose bilateral mastectomy rather than lumpectomy and radiation. Mutation carriers who undergo mastectomy are less likely to develop a second breast cancer.

Are there targeted therapies for treating cancer in people with a TP53 mutation?

Currently there are no FDA-approved targeted therapies or guidelines developed specifically for treating cancer in people with a TP53 mutation, however, there may be research studies looking at treatments that may work well for people with acquired (somatic) or inherited (germline) TP53 mutations. 

People with a cancer diagnosis and an inherited TP53 mutation may benefit from biomarker testing and may qualify for clinical trials looking for more effective treatments for cancer.