Cancer Risk
Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.Stay up to date on research and information
Sign Up for FORCE NewslettersCancer Risk Associated with Inherited Mutations
If you have tested positive for an inherited mutation, we recommend consulting with a genetics expert who can look at your personal and family history of cancer and can help you decide on a risk-management plan.
Note that when we use the term "men" we are referring to the sex you were assigned at birth.
Risks for men with a mutation
mutations increase the risk for cancer. This risk may be associated with a younger age of diagnosis. More research is needed to better measure the lifetime cancer risk associated with a mutation in this gene.
Other cancer risks for people with a mutation
There is not yet enough research to conclude that a mutation increases the risk of other cancers. Research on the risk for cancer in people with mutations is ongoing.
Get Support
The following organizations offer peer support services for people with or at high risk for cancer:
- FORCE peer support
- Visit our message boards.
- Once you register, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Sign up for our Peer Navigation Program.
- Users are matched with a volunteer who shares their mutation and situation.
- Join our private Facebook group.
- Find a virtual or in-person support meeting.
- Join a Zoom community group meeting.
- Visit our message boards.
- ZERO-The End of Cancer is a nonprofit organization that provides information and support resources for men with cancer.
Get Support
FORCE offers many peer support programs for people with inherited mutations.
- Our Message Boards allow people to connect with others who share their situation. Once registered, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Our Peer Navigation Program will match you with a volunteer who shares your mutation and situation.
- Our moderated, private Facebook group allows you to connect with other community members 24/7.
- Check out our virtual and in-person support meeting calendar.
- Join one of our Zoom community group meetings.
Open Clinical Trials
The following are studies looking at ways to screen for cancer in people at high risk:
- NCT05129605: Cancer Genetic Risk Evaluation and Screening Study (PROGRESS). This study will look at how enhanced cancer screening using will improve early detection rates and further understanding of how inherited mutations can lead to development of cancer.
- NCT03805919: Men at High Genetic Risk for Cancer. This is a cancer screening study using in high risk men. This study is open to men with an in any of the following genes: , , , , , , , , , , , , , , or FANCA.
- NCT04472338: Screening for Men With Inherited Risk of Developing Aggressive Cancer, PATROL Study. This study is looking at ways to detect cancer earlier in men who are at increased genetic risk of developing cancer that forms, grows, or spreads quickly (aggressive). The study is open to men with mutations associated with cancer risk.
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NCT05608694: Screening in Men at High Risk of Developing Cancer. The purpose of this study is to determine whether or not Magnetic Resonance Images () will identify high-grade cancers earlier and more frequently in men at high risk of developing cancer.
Open Clinical Trials
NCT02665195: Registry Of MultiPlex Testing (PROMPT). PROMPT is an online research registry. The goal of PROMPT is to help researchers to better understand the risks that are linked to mutations in less well-studied genes. People with inherited mutations can enroll in PROMPT to help researchers learn more about cancer risks.