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PMS2 (Lynch Syndrome): Cancer Risks
People with a mutation in the PMS2 gene have Lynch syndrome and an increased risk for several types of cancer. Learn about these cancer risks. Stay up to date by signing up for our community newsletter.
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Cancer Risks Associated with Inherited PMS2 Mutations
If you have tested positive for a mutation, we recommend speaking with a genetics expert who can assess your personal and family history of cancer, and can help you decide on a plan to manage your cancer risk.
People with an inherited mutation have an increased lifetime risk for several cancers. Additionally, the cancers tend to occur at a younger age than people in the general population. The following are the most common cancers:
- colorectal
- lifetime risk of 8.7 - 20 percent compared to 4 percent in the general population.
- average age of diagnosis is 61-66 compared to 68 - 72 in the general population.
- endometrial
- lifetime risk of 13-26 percent compared to 3 percent in the general population.
- average age of diagnosis is 49 - 50 compared to 60 in the general population.
It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years will vary depending on:
- current age
- specific mutation
- personal and family health history
- diet, exercise, lifestyle and other factors
Last updated June 09, 2025