Cancer risk associated with inherited CHEK2 mutations
If you have tested positive for an inherited CHEK2 mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you choose the best plan for managing your cancer risk.
Breast cancer risk
- Women have a lifetime risk of about 37 percent.
- Men may also be at increased risk for breast cancer, but the exact risk is unknown.
Colorectal cancer risk
Both men and women who inherit a CHEK2 mutation are at increased risk of colorectal cancer. More research is needed to understand the lifetime colorectal cancer risk for people with CHEK2 mutations.
- NCT02665195: Prospective Registry Of MultiPlex Testing (PROMPT). PROMPT is an online research registry. The goal of PROMPT is to help researchers to better understand the risks that are linked to mutations in less well-studied genes. People with CHEK2 mutations can enroll in PROMPT to help researchers learn more about cancer risks.