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Study to Determine if Breast Cancer Screening can be Made Better by Personalizing Each Woman’s Mammogram Schedule

Study Contact Information:

The study is being conducted by researchers at the University of California and at Sanford Health in the Midwest. Contact Information: by phone at 855-729-2844 or by email.


The WISDOM Study: Women Informed to Screen Depending on Measures of Risk

About the Study

The goal of the Wisdom Study is to determine if breast cancer screening can be made better by personalizing each woman’s schedule, compared to the current one-size-fits-all, annual approach. The Wisdom Study is designed to end the confusion about when to start and how often to have a . For more information, visit the WISDOM Study website

Type of Study

The Wisdom Study is testing a personalized approach to breast screening versus standard annual screening. Women can now choose which study group they would like to participate in. The WISDOM Study has been going on since 2016 and started as a trial, but has now shifted it’s design so participants can choose their study group.

What the Study Entails

  • Participants in the personalized arm
    • These women will be asked to submit saliva samples for genetic testing of 9 genes associated with increased breast cancer risk. They will also have a type of test known as whole genome sequencing to create a risk calculation known as a "polygenic risk score."
    • A genetic testing kit will be mailed to the participant’s home address.
    • In conjunction with their results from the genetic test, other risk factors like family history, breast density, and previous breast biopsies will be used to determine a woman’s risk for breast cancer according to the Breast Cancer Surveillance Consortium (BCSC) model.
    • Their risk results will shape their screening schedule:
      • The high-risk women will be recommended to alternate mammograms and ’s once every six months.
      • The lowest-risk women will be recommended  once every other year after age 50 for the women at lowest risk.
      • Other screening schedules will be recommended based on a participant’s individual risk (once a year, every two years, etc).
    • These screenings can occur at the clinic of choice for the participants. Women with concerning mutations will be contacted by a genetic counselor to further explain and inform women of their risk. This consultation is done over the phone and before a woman receives any results with concerning mutations.
  • Women in the annual screening arm do not receive genetic testing. These women will simply get one a year at the clinic of their choice.

Participants in both groups will then be asked to complete annual follow-up surveys in the years to come about changes in their breast health.

Details on the Enrollment Process

Participation is done completely online by signing up at There is no need to come to a participating center as the study can be completed at home. By joining the study, every woman will gain a better understanding of her personalized breast cancer risk, but also help us chart the way forward for breast cancer screening and prevention. 

Stepwise process:

  1. Visit to learn more about the study
  2. To participate: click Join Now
  3. You will be prompted to complete an Eligibility Survey 
    • If you are confirmed eligible, you will be prompted to create a Portal Password. This along with the email address you providing when completing the Eligibility Survey will serve as your login credentials for your personal Wisdom portal. This web portal is where you will login to view your unique study related information.
  4. Select a Study Group
  5. Review the Consent and HIPAA forms
  6. If you decide that you would like to participate, complete the Consent and HIPAA forms by signing the forms via DocuSign.
  7. Complete the following surveys:
    • Personal Profile Page
    • Breast Health Questionnaire
    • Well-being Survey
  8. If you chose to be in the personalized arm, a genetics (saliva) test will be mailed to you at your home address with instructions on how to complete.

*Some insurance companies have partnered with the Wisdom Study and are covering the genetics test as part of their covered services. Please note that no individual woman will be billed for the genetics test. It will be covered by participating insurers or by the study.

Study Lead Investigator

Laura Esserman, MD MBA: University of California San Francisco

This Study is Open To:
  • Females
  • 40 to 74 years old
  • Reside in the United States


This Study is Not Open To:
  • Males
  • Prior breast cancer or ductal carcinoma in situ () diagnosis
  • History of mastectomy