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FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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111 through 120 of 310

Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Update : FDA approves Orgovyx, the first oral hormone therapy of its type for treating advanced prostate cancer

Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Most relevant for: Men with advanced prostate cancer

In December 2020, the FDA approved Orgovyx to treat advanced prostate cancer. The findings were based on the HERO clinical trial of more than 900 men. Data from this trial showed the new therapy was safer than standard androgen deprivation treatment for men with advanced prostate cancer and risk of cardiovascular disease. (2/18/21)

Este artículo está disponible en español.

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Study : Breastfeeding may lower risk of ovarian cancer in women with BRCA mutations

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Most relevant for: Women considering breastfeeding who have inherited BRCA mutations.

Data from a large-scale study suggests that breastfeeding may protect against ovarian cancer in women with inherited mutations in BRCA1 or BRCA2. (1/28/21)

Este artículo está disponible en español.

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

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Study : How breast cancer patients experience hormone therapy

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

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Most relevant for: Breast cancer patients taking or considering taking hormone therapy

Side effects from hormone therapy are a common reason that many men and women with hormone receptor-positive breast cancer stop treatment early. Some people never start hormone therapy. This study asked patients about their experiences with hormone (or endocrine) therapy. The results suggest that there may be ways to improve the number of patients who stick with therapy. Patients need better ways to manage hormone therapy-related side effects. (1/19/21)

Este artículo está disponible en español.

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Relevance: High

Research Timeline: Post Approval

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Update : FDA approves new imaging drug for detecting spread of prostate cancer

Relevance: High

Research Timeline: Post Approval

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Most relevant for: Men with prostate cancer

On December 1, 2020 the FDA approved a new type of imaging technology to confirm the spread of newly diagnosed prostate cancer that is suspected to be metastatic. The approval also includes use for confirming suspected recurrence in men who have rising PSA after treatment. The approval is based on two clinical trials that showed this new technique to be safe and consistent in accurately detecting cancer that has spread beyond the prostate gland. (1/7/21)

THIS INFORMATION HAS BEEN UPDATED on 5/10/2022:  On March 23, 2022 the U.S. Food and Drug Administration (FDA) approved a new drug called Pluvicto to treat patients with metastatic castration-resistant prostate cancer. ON the same day, the FDA also approved a new imaging drug called Locametz (a brand of Gallium 68 PSMA-11) for identification of those patients who would benefit from treatment with Pluvicto. Read about the FDA approval of Pluvicto and Locametz here.

Este artículo está disponible en español.

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Study : Women support delayed removal of ovaries

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Most relevant for: Women at high risk of ovarian cancer who are considering undergoing risk-reducing surgery.

Risk-reducing early removal of fallopian tubes followed by removal of ovaries at a later date was acceptable to women at high risk of ovarian cancer due to an inherited mutation in a recent study. This was especially true for women worried about sexual dysfunction associated with surgical menopause. (12/24/20)

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Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Study : Immunotherapy drug Keytruda received FDA approval and showed benefit for treatment of colorectal cancer

Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Most relevant for: People with advanced colorectal cancer and a type of biomarker called MSI-High (MSI-H)

In June 2020, the FDA approved Keytruda (pembrolizumab) as an initial therapy for advanced colorectal cancer. This approval was based on the results from the KEYNOTE-177 study. In this study, Keytruda was more successful than chemotherapy in delaying progression of certain types of colorectal cancers. (11/25/20)

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Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Study : Trodelvy clinical trial results likely practice-changing for people with metastatic triple-negative breast cancer

Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Most relevant for: People with metastatic triple-negative breast cancer

The ASCENT study confirmed an earlier study and showed that the drug sacituzumab govitecan-hizy (Trodelvy) improves outcomes for people with previously treated metastatic triple-negative breast cancer. These results further support the use of Trodelvy as a standard therapy for patients with pretreated metastatic triple-negative breast cancer. (11/20/20)

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Relevance: Medium-Low

Strength of Science: Medium-High

Research Timeline: Animal Studies

Study : The buzz about honeybee venom: Promising early research to treat breast cancer

Relevance: Medium-Low

Strength of Science: Medium-High

Research Timeline: Animal Studies

Most relevant for: People with breast cancer particularly those with HER2-positive or triple-negative breast cancer.

Early research showed that melittin, an ingredient in honeybee venom, may be used to treat HER2-positive and triple-negative breast cancers. This study found that melittin can kill cancer cells. The chemotherapy drug docetaxel more effectively killed breast cancer cells in mice when combined with melittin. It is not known whether melittin would be safe or affect cancer growth in people. While promising, more research must be done before melittin could be used to treat people.  (11/10/20)

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Relevance: Medium

Strength of Science: Medium

Research Timeline: Post Approval

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Study : Inherited gene mutations found in pancreatic cancer families in Spain

Relevance: Medium

Strength of Science: Medium

Research Timeline: Post Approval

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Most relevant for: People with pancreatic cancer and a family history of pancreatic or other cancers

This study looked for inherited mutations in genes known to be linked to hereditary pancreatic cancer. The results provide additional evidence that most hereditary pancreatic cancer is due to inherited mutations in genes that were previously associated with other forms of cancer. (10/29/20)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

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Study : Knowing about an inherited BRCA mutation improves outcomes for women with breast cancer

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

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Most relevant for: Young women with, or at high risk for an inherited BRCA mutation

Inherited mutations in the BRCA1 and BRCA2 genes are linked to a high lifetime risk of breast and other cancers. This study shows that women who know that they have a BRCA mutation before they are diagnosed with breast cancer have improved outcomes including diagnosis at earlier stages and improved overall survival. (10/26/20)

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