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FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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21 through 30 of 58

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Prevalence of BRCA founder mutations in Bahamian women

Most relevant for: Bahamanian women

The Bahamas has the highest known frequency of BRCA mutations among people diagnosed with breast cancer. This study reviewed whether population-based BRCA testing (testing everyone regardless of family or personal history of cancer) would be an effective approach for finding mutation carriers in the Bahamas. (3/4/19)

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Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

Study : Inherited breast cancer in Nigerian women

Most relevant for: Nigerian women or women of Nigerian descent who have breast cancer

A new study shows that among Nigerian women, one in eight cases of breast cancer is due to an inherited mutation in BRCA1, BRCA2, PALB2 or TP53. (12/5/18)

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Relevance: High

Strength of Science: High

Research Timeline: Post Approval

Study : Can population-based DNA sequencing find more people at risk for hereditary cancers?

Most relevant for: Women over age 30

It is well documented that many BRCA mutation carriers are missed using current family history-based screening approaches. As a result, experts are beginning to call for population-based BRCA genetic testing—an organized effort to screen all women like we do for breast and cervical cancer.  A recent study looked at whether a population-based genetic testing approach would better identify mutation carriers compared with current practice. (11/17/18)

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Relevance: High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Surgeon attitude impacts rate of genetic testing after a breast cancer diagnosis

Most relevant for: Young women diagnosed with breast cancer who have not yet had genetic testing

A study in JAMA Surgery this year examined the factors that impact genetic testing after a breast cancer diagnosis. This study suggests that the attitudes of attending surgeons about genetic testing have the most impact on whether patients receive testing. (10/6/18)

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Relevance: Medium-Low

Strength of Science: Medium

Research Timeline: Human Research

Study : A new method for determining whether genetic variants in BRCA1 increase cancer risk

Most relevant for: People who have a Variant of Uncertain Significance in a gene associated with cancer risk.

Ever since BRCA1 was discovered, researchers have been trying to understand which of the thousands of possible DNA changes in this gene increase cancer risk and which are harmless changes.  A new study in Nature reports how a cutting-edge technology called “genome editing” may be used to classify changes—known as variants of uncertain significance-in BRCA1 as harmful or harmless. Once validated, this same technology may be used to classify variants in other genes. (9/29/18)

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Relevance: Medium-High

Quality of Writing: Medium-High

Article : Cancer experience in families affects decision making

Most relevant for: Women with an inherited mutation linked to increased risk for cancer

Women with inherited mutations in genes that increase breast and ovarian cancer risk have an additional challenge: coping with how those mutations impact their families and how a family member’s cancer experience can shape their own perception. In a recent U.S. News and World Report article, Elaine Howley explores how a woman's decisions about healthcare, cancer prevention and treatment are affected by experience with cancer in the family. (9/25/18)

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Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

Study : Hormone therapy and breast cancer risk after ovary removal in women with a BRCA1 mutation

Most relevant for: Women with BRCA1 mutations who have had risk-reducing ovary removal and have never been diagnosed with breast cancer

Does hormone therapy (HT) alter the risk of breast cancer for woman carrying a BRCA1 mutation who have never been diagnosed with cancer? In this study, researchers showed that among women with BRCA1 mutations, HT use did not increase breast cancer rates for 10 years after ovary removal. More women taking combined estrogen plus progesterone developed breast cancer compared to those taking estrogen only, though this difference was not statistically significant. (9/7/18)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Study identifies genes associated with risk of triple-negative breast cancer

Most relevant for: People diagnosed with triple-negative breast cancer

Panel testing can identify women who are at increased risk for breast cancer.  However, those at risk for triple-negative breast cancer cannot easily be identified because other than BRCA1, genes that increase the risk for triple-negative breast cancer are unknown.  A new study uses panel testing to identify which genes increase the risk for triple-negative breast cancer. (8/23/18)

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Relevance: Medium

Strength of Science: Medium

Research Timeline: Human Research

Study : Evaluation of some direct-to-consumer genetic testing reveals inaccuracies and misinterpretations

Most relevant for: People who are considering or have had direct-to-consumer testing

A clinical genetic testing laboratory examined results from direct-to-consumer genetic testing ordered directly by patients. They found many instances of false positives—reported mutations that were not actually present—and in some cases, reports of variants that "increased risk," but were actually benign. This study emphasized the importance of involving genetics experts in the interpretation of genetic test results. (6/28/18)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

Study : Mutations in Lynch syndrome genes MSH6 and PMS2 may be associated with breast cancer

Most relevant for: Women with an MSH6 or PMS2 mutation

Some women with mutations in MSH6 and PMS2, two Lynch syndrome genes, may have a modest (2 to 3-fold) increased risk for breast cancer. (6/14/18 updated 09/25/19)

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