Update: Genetic causes of hereditary pancreatic cancer: BRCA and beyond

Printer Friendly Page

Contents

At a glance Clinical trials                       
Beyond BRCA      Guidelines            
Genes associated with pancreatic cancer Questions to ask your doctor          
What does this mean for me? Resources and references


UPDATE AT A GLANCE

This update is about:

Inherited mutations in pancreatic cancer genes and the importance of identifying patients who have them.

Why is this update important?

Between 10–20 percent of all pancreatic cancer is thought to be due to an inherited mutation.

  • About 3-10 percent of people with pancreatic cancer have a family history of the disease. 
  • Inherited mutations in BRCA1 and BRCA2 are the most common cause of familial pancreatic cancer. Together, about 6 percent of all pancreatic cancer patients have an inherited mutation in BRCA2 or BRCA1.
  • Almost 14 percent of Ashkenazi Jewish people with pancreatic cancer have a BRCA mutation.
  • Studies looking at patients who do not have a family history of pancreatic cancer have found that 4-11 percent have an inherited mutation in a gene associated with pancreatic cancer.

Beyond BRCA

Genetic panel testing, which looks for mutations in many genes at one time rather than just 1 or 2 at a time, has become more widespread in recent years and has led to a better understanding of which genes contribute to hereditary pancreatic cancer. Genes that are generally included in panel testing include BRCA1, BRCA2, ATM, CDKN2A, PALB2, STK11, MLH1, MSH2, MSH6 and PMS2.

Of these genes, panel testing has shown that:

  • Mutations in ATM are found in 2-3 percent of pancreatic cancer cases.
  • Mutations in Lynch syndrome genes (MLH1, MSH2, MSH6, and PMS2) are found in <1 percent of cases.
  • Mutations in other genes (CDKN2A, PALB2, and STK11) are found in fewer than < 1 percent of cases.

One study found that 17 percent of patients with a family history of pancreatic cancer who had panel testing had an inherited mutation, suggesting the importance of family history. Being diagnosed at a younger age was also associated with an increased likelihood of having a mutation.

Genes associated with hereditary pancreatic cancer and risk

The lifetime risk for pancreatic cancer in the general population is 1.6 percent. The general population includes people with and without mutations. People with the following mutations had an increased risk for pancreatic cancer compared to people without a mutation.

Gene     Increase in Pancreatic Cancer Risk Compared to 
Someone Without the Mutation
Other Associated Cancers
ATM           Unclear Breast
BRCA1    2-4 times Breast, ovarian, prostate
BRCA2 3-8 times Breast, ovarian, prostate, melanoma
CDKN2A 13-22 times    Melanoma
MLH1, MSH2, MSH6, PMS2EPCAM 
(Lynch Syndrome)
Up to 9 times Colorectal, endometrial (uterine), ovarian, prostate
PALB2     Unclear Breast
STK11 (Peutz-Jeghers Syndrome)    132 times    Breast, gastrointestinal, gynecological
Source: Robert Pilarski, MS, LGC, MSW, LSW, ASCO June 2019

Summary:

In addition to mutations in BRCA1 and BRCA2, numerous other inherited mutations increase the risk of pancreatic and other cancers. The National Comprehensive Cancer Network (NCCN) now recommends that all pancreatic cancer patients be offered genetic testing and counseling to determine whether they have inherited a germline mutation. Those who test positive for an inherited mutation may be eligible for different treatment options, such as PARP inhibitors or immunotherapies, and they may require screening for additional cancers. They may also need to alert their family members to the increased risks of certain cancers.  Finally, the identification of mutations may make a patient eligible for specific clinical trials that are looking at targeted therapies for carriers of particular mutations.

What does this mean for me?

If you have been diagnosed with pancreatic cancer, you should speak with your health care provider about receiving genetic counseling and testing to determine if you might carry an inherited mutation in a gene that is associated with hereditary pancreatic cancer. The results may be important for your treatment (including enrollment in clinical trials) and for your family.

If you have a family history of pancreatic cancer, you should speak with a health care provider about referral for genetic counseling and testing. 

If you do not have pancreatic cancer but you know that you carry an inherited mutation in a relevant gene (see the table in this article) and you meet the screening guidelines outlined here, you should speak to your health care provider about receiving annual screening for pancreatic cancer.

Conclusions:

Inherited mutations in a number of genes are associated with increase pancreatic cancer risk. It is important that people with pancreatic cancer are offered genetic testing and counseling to determine if they carry a germline mutation in one of these genes, as the results can impact treatment decisions, screening and risk management for other cancers, and family members’ risk. It is also important that people without pancreatic cancer but with an inherited mutation in a known pancreatic cancer risk gene are aware of screening guidelines and receive screening as appropriate.

Share your thoughts on this XRAYS article by taking our brief survey.

(back to top)

This article is relevant for:

People diagnosed with pancreatic cancer

This article is also relevant for:

People with a genetic mutation linked to cancer risk

Newly diagnosed

Pancreatic cancer survivors

Be part of XRAY:

Questions to Ask
  • Should I have genetic testing for an inherited mutation? 
  • I had genetic testing in the past, should I have additional testing? 
  • Should I have pancreatic cancer screening? 
  • Will my insurance pay for pancreatic cancer screening?
Clinical Trials

Studies enrolling people diagnosed with pancreatic cancer

Studies enrolling people at high risk for pancreatic cancer

 

 

 

Back to XRAY Home