Genes linked to risk
The most common genes associated with risk are:
- and are associated with an increased risk for breast, ovarian, pancreatic, and other cancers. Estimates are that about 1 out of 500 people in the United States has an inherited or mutation. In Jewish people the risk is higher and about 1 in 40 people of Eastern European Jewish ancestry has a mutation in or .
- , , , , and are the gene responsible for . is associated with an increased risk for colon, endometrial (uterine) and other cancers. About 1 in 300 people in the United States has an in a gene.
Genes included in multi-gene panel tests
Multi-gene panel tests look for inherited mutations in many genes at the same time. Most panels look for mutations in one or more of the following genes:
Different companies may include additional genes in their panel tests. A genetics expert can make sure that the most appropriate test is ordered based on your personal situation and family medical history. A genetic counselor can also make sure that your results are interpreted correctly.