General information for people with inherited BRIP1 mutations
Both men and women can carry a mutation in the BRIP1 gene.
Women who inherit a BRIP1 mutation have an increased risk of ovarian cancer. Research on whether an inherited BRIP1 mutation increases the risk for other cancers in both men and women is ongoing. See our Cancer Risk section for more information.
There are guidelines for screening and prevention for certain cancers in people with a BRIP1 mutation. Clinical trials may also be available for people who test positive for a BRIP1 mutation. See our Risk Management section for more information about screening and prevention options in people with this mutation.
People with a BRIP1 mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. Visit our Cancer Treatment section for more information about treatment clinical trials for people with a BRIP1 mutation.
Inheriting two mutations in BRIP1—one from each parent—causes a rare disease known as Fanconi anemia. See our Other Considerations section for more information about this disease.
The name BRIP1 stands for "BRCA1 Interacting Protein 1." This gene is located on chromosome 17. BRIP1 works with BRCA1 to repair DNA damage. Although the two genes work together, the effects of a mutation are different; people with a BRIP1 mutation do not have the same cancer risk as people with a BRCA1 mutation.
If you are a person with an BRIP1 mutation, you can find peer support through the following resources:
- Register for the FORCE Message Boards to connect with others who share your situation. Once you register, you can post on the Share Your Mutation board to connect with other people who carry an BRIP1 mutation.
- FORCE's Peer Navigation Program will match you with a volunteer who shares your mutation and situation and provide you with a free resource guide.
- Contact the FORCE impact leaders in your area to link to local support groups and other resources.
- Attend a virtual support meeting in your area.
- Read the stories from members of our community.