BRIP1 Gene Mutation
Information about Inherited Mutations
What is BRIP1?
BRIP1 is a gene that helps repair damage to your . People who are born with changes—called mutations—in their BRIP1 gene have an increased risk for certain types of cancer.
Which cancers are associated with a BRIP1 mutation?
Mutations in the BRIP1 gene have been linked to an increased risk for and ovarian cancer. Researchers are studying whether these mutations increase the risk for other cancers.
Does everyone with a BRIP1 mutation develop cancer?
Although the lifetime risk for cancer with a BRIP1 mutation is higher than average, not everyone with the mutation develops cancer. Following the risk-management guidelines can help people with BRIP1 mutations avoid a cancer diagnosis.
What can people with a BRIP1 mutation do?
Expert guidelines include recommendations for people with BRIP1 mutations on managing their cancer risk.
People with a BRIP1 mutation who have been diagnosed with some types of cancer may qualify for specific treatments or clinical trials using targeted therapies.
There may be other medical concerns, including a rare childhood disease known as Fanconi anemia which can happen in people who inherit a mutation in both copies of their BRIP1 gene.
If you test positive for a BRIP1 mutation, you should inform your close blood relatives (first-, second-, and third-degree relatives) about your test results and encourage them to speak with a genetics expert.
More detailed information for people with inherited BRIP1 mutations is highlighted below.
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More Information for People with BRIP1 Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for cancer in people with inherited BRIP1 mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a BRIP1 mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
Tumor biomarker testing and genetic testing can provide additional clues about which treatments may work best for your cancer. People who test positive for a BRIP1 mutation may have additional treatment or clinical trial options available to them.
Other Considerations
People who inherit a mutation in both copies of their BRIP1 gene—one from each parent—have a rare disease known as Fanconi anemia. Learn additional information about inherited BRIP1 mutations.
More Resources
Participate in Prevention Research
The screening and prevention studies below are enrolling people with BRIP1 mutations. To search for more studies, visit our Search and Enroll Tool.
Screening Study for Men at High Genetic Risk for Prostate Cancer
Clinicaltrials.gov identifier: NCT03805919
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier: NCT05129605
Clinicaltrials.gov identifier: NCT05287451
Participate in Treatment Research
The treatment studies below are enrolling people with BRIP1 mutations. To search for more studies, visit our Search and Enroll Tool.
