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General information for people with inherited  mutations

Both men and women can carry a mutation in the  gene. 

Women who inherit a  mutation have an increased risk of ovarian cancer. Research on whether an inherited mutation increases the risk for other cancers in both men and women is ongoing. See our Cancer Risk section for more information.

There are guidelines for screening and prevention for certain cancers in people with a mutation. Clinical trials may also be available for people who test positive for a mutation. See our Risk Management section for more information about screening and prevention options in people with this mutation.

People with a mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. Visit our Cancer Treatment section for more information about treatment clinical trials for people with a mutation.

Inheriting two mutations in —one from each parent—causes a rare disease known as Fanconi anemia. See our Other Considerations section for more information about this disease.

The name stands for " Interacting Protein 1." This gene is located on chromosome 17. works with to repair damage. Although the two genes work together, the effects of a mutation are different; people with a mutation do not have the same cancer risk as people with a mutation.

Last updated September 19, 2022

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FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022