BRIP1 Inherited Mutations
Learn about the cancer risks and prevention and treatment options for people with an inherited BRIP1 mutationStay up to date on research and information
Sign Up for FORCE NewslettersInformation for People with an Inherited Mutation
Mutations in the gene have been linked to increased risk for and ovarian cancer. Researchers are studying whether these mutations increase the risk for other cancers. Expert guidelines include recommendations for people with mutations on managing their cancer risk.
People with a mutation who have been diagnosed with some types of cancer may qualify for specific treatments or clinical trials using targeted therapies.
There may be other medical concerns, including a rare childhood disease known as Fanconi anemia which can happen in people who inherit a mutation in both copies of their gene.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for cancer in people with inherited mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
Tumor testing and genetic testing can provide additional clues about which treatments may work best for your cancer. People who test positive for a mutation may have additional treatment or clinical trial options available to them.
Other Considerations
People who inherit a mutation in both copies of their gene—one from each parent—have a rare disease known as Fanconi anemia. Learn additional information about inherited mutations.
More Resources
Participate in Prevention Research
The screening and prevention studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier:
NCT05129605
Participate in Treatment Research
The treatment studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Clinicaltrials.gov identifier:
NCT04666740
Clinicaltrials.gov identifier:
NCT04030559
Clinicaltrials.gov identifier:
NCT04038502
