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General information for people with inherited  mutations

People with an in have an increased risk for certain cancers.  See the Cancer Risk section for more information.  There are guidelines for prevention for certain cancers in people with a mutation. There also may be clinical trials available for people who test positive for a mutation.  See our Risk Management section for more information about medical recommendations in people with mutations. 

People who have a mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information about clinical trials for people with a mutation.

Inheriting a mutation from both parents can cause Fanconi anemia. See our Other Considerations section for more information about this disorder.

More information about the gene

The gene is located on chromosome 17. is involved in repair.

Last updated January 02, 2024

Get Support
Get Support

FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022

Open Clinical Trials
Open Clinical Trials

NCT02665195: Registry Of MultiPlex Testing (PROMPT). PROMPT is an online research registry. The goal of PROMPT is to help researchers to better understand the risks that are linked to mutations in less well-studied genes. People with inherited mutations can enroll in PROMPT to help researchers learn more about cancer risks. 

updated: 05/29/2023