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General information for people with inherited  mutations

Both men and women can carry a mutation in the  gene. 

Women who inherit a mutation have an increased risk of breast cancer. Research on whether inherited mutations increase the risk for other cancers has been inconsistent. See our Cancer Risk section for more information. 

Currently, there is not enough evidence on how best to manage cancer risk in people with a mutation. See our Risk Management section for more information.

People with a  mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. Visit our Cancer Treatment section for more information about treatment options for people with a  mutation.

The name stands for " Associated Ring Domain 1."  is located on chromosome 2. The   gene works with to repair damaged . Although the two genes work together, the effects of a mutation are different; people with a mutation do not have the same cancer risk as people with a mutation.



Last updated September 19, 2022

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FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022