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Hereditary Cancer and Genetic Testing

General information for people with inherited  mutations

Mutations in are rare. Both men and women can carry a mutation in the gene. Mutations in  cause  (PJS). Some people with mutations have mutations that they did not inherit from either parent. These are known as "de novo" mutations. People with de novo mutations can pass them on to their children. 

People with an inherited mutation in have an increased risk for certain cancers, as outlined in the Cancer Risk section. There are guidelines for screening and prevention for certain cancers in people with an mutation. There may also be clinical trials available. See our Risk Management section for more information about screening options in people with an inherited mutation. 

People with an inherited mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information.

(PJS) can cause traits that are not related to cancer. See our Other Considerations section for more information about this syndrome.

The name stands for "Serine/Threonine Kinase 11." The gene is also referred to as LKB1. It is located on chromosome 19. stops cells from growing and dividing too quickly.

Last updated March 18, 2022

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FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022