STK11 Gene Mutations (Peutz-Jeghers Syndrome)
Information for People with Inherited Mutations
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What is an STK11 mutation?
Inherited STK11 mutations cause a condition known as Peutz-Jeghers syndrome.
What are the cancer risks for people with an STK11 mutation?
People with an in STK11 have a very high lifetime risk for different types of cancers, including:
- breast cancer
- colorectal cancer
- endometrial cancer
- lung cancer
- pancreatic cancer
- stomach cancer
- small intestinal cancer
- other cancers
What can people with an STK11 mutation do?
There are expert guidelines with recommendations for screening and prevention of these cancers.
People with STK11 mutations can develop medical conditions beyond cancer, beginning at an early age. There may be family planning considerations for people with an inherited STK11 mutation.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on STK11 Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited STK11 mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a STK11 mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
People with a STK11 mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
Other Considerations
People with STK11 mutations can develop medical conditions beyond cancer, beginning at an early age. Learn about other important considerations for people with inherited STK11 mutations.
Participate in Research
The studies below are enrolling people with STK11 mutations. To search for more studies, visit our Search and Enroll Tool.
Pancreatic Cancer Screening Study for High Risk People
Clinicaltrials.gov identifier: NCT03250078
Pancreatic Cancer Early Detection for People at High Risk
Clinicaltrials.gov identifier: NCT04970056