Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.
General information for people with inherited mutations
Mutations in are rare. Both men and women can carry a mutation in the gene. Mutations in cause (PJS). Some people with mutations have mutations that they did not inherit from either parent. These are known as "de novo" mutations. People with de novo mutations can pass them on to their children.
People with an inherited mutation in have an increased risk for certain cancers, as outlined in the Cancer Risk section. There are guidelines for screening and prevention for certain cancers in people with an mutation. There may also be clinical trials available. See our Risk Management section for more information about screening options in people with an inherited mutation.
People with an inherited mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information.
(PJS) can cause traits that are not related to cancer. See our Other Considerations section for more information about this syndrome.
The name stands for "Serine/Threonine Kinase 11." The gene is also referred to as LKB1. It is located on chromosome 19. stops cells from growing and dividing too quickly.
FORCE offers many peer support programs for people with inherited mutations.
- Our Message Boards allow people to connect with others who share their situation. Once you register, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Our Peer Navigation Program will match you with a volunteer who shares your mutation and situation.
- Our moderated, private Facebook group allows you to connect with other community members 24/7.
- Check out our virtual and in-person support meeting calendar.
- Join one of our Zoom community group meeting:
- Meetings in American Sign Language
- Meetings in Spanish
- People of Color
- Young Previvors
- Young Survivors