General information for people with inherited mutations
Both men and women can carry a mutation in the gene.
Inherited mutations in the gene are associated with . Other names for include Hereditary Nonpolyposis Colorectal Cancer () and Muir-Torre syndrome, which refers to a subset of in which people have an increased risk of developing uncommon skin tumors.
People with inherited mutations have increased risk for many cancers but particularly cancers of the large intestine (the colon and the rectum) and uterus (endometrium). See our Cancer Risk section for more information. There are guidelines for screening and prevention for certain cancers in people with an mutation. Clinical trials may also be available for people who test positive for an mutation. See our Risk Management section for more information about screening and prevention options.
People with an inherited mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. Visit our Cancer Treatment section for more information about treatment for people with an mutation.
Children who inherit a mutation from both their mother and father can have a rare syndrome known as “constitutional (CMMRD),” which can cause high risks of various cancers in childhood and young adulthood. See our Other Considerations section for more information about this disease.
The name stands for "MutS homolog 2." The gene is located on chromosome 2. The gene protein plays an important role in repairing damage.
FORCE offers many peer support programs for people with inherited mutations.
- Our Message Boards allow people to connect with others who share their situation. Once registered, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Our Peer Navigation Program will match you with a volunteer who shares your mutation and situation.
- Our moderated, private Facebook group allows you to connect with other community members 24/7.
- Check out our virtual and in-person support meeting calendar.
- Join one of our Zoom community group meetings.