Hereditary Cancer and Genetic Testing

General information for people with inherited CDH1 mutations

Both men and women can carry a mutation in the CDH1 gene.  

People with an inherited mutation in CDH1 have an increased risk for certain cancers.  See our Cancer Risk section for more information. There are guidelines for screening and prevention for certain cancers in people with a CDH1 mutation. Clinical trials may also be available for people who test positive for a CDH1 mutation. See our Risk Management section for more information for screening and prevention recommendations for people with CDH1 mutations. 

People diagnosed with a CDH1 mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information about clinical trials for people with a CDH1 mutation.

There is a very rare and serious disorder called blepharocheilodontic (BCD) syndrome that has been infrequently associated with CDH1 mutations.  See our Other Considerations section for more information about this disorder.

The name CDH1 stands for "Cadherin 1." The gene is located on chromosome 16. CDH1 helps cells stick to one another to form tissues and organs. 


If you are a person with a CDH1 mutation, you can find peer support through the following resources:

You can also find support through this organization:

  • No Stomach for Cancer is a nonprofit with a mission to support research and unite the caring power of people worldwide affected by stomach cancer.