Hereditary Cancer and Genetic Testing

General information for people with inherited TP53 mutations

Both men and women can carry a mutation in TP53. Inherited mutations in TP53 are associated with Li-Fraumeni syndrome.

People with an inherited mutation in TP53 have increased risk for certain cancers. The lifetime cancer risk for people with Li-Fraumeni syndrome is high, and many people have more than one cancer. See our Cancer Risk section for more information. 

There are guidelines for screening and prevention for certain cancers in people with a TP53 mutation. See our Risk Management section for more information about screening and prevention options in people with this mutation.

People with an inherited TP53 mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. Visit our Cancer Treatment section for more information.

Certain families with TP53 mutations may have Li-Fraumeni-like syndrome.  See our Other Considerations section for more information about this disease.

The TP53 (tumor suppressor protein 53 or p53) gene is located on chromosome 17. TP53 helps in the repair of damaged DNA


If you are a person with a TP53 mutation, you can find peer support through the following resources: