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General information for people with inherited  mutations

Both men and women can carry a mutation in the  gene. 

People with an in  have a very high lifetime risk for different types of cancers, as outlined in the Cancer Risk section. There are guidelines for screening and prevention for certain cancers in people with a  mutation. There may also be clinical trials available. See our Risk Management section for more information about screening options in people with an inherited  mutation. 

People with an inherited  mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information.

Some mutations in cause or Bannayan-Riley-Ruvalcaba syndrome. Together these syndromes are known as Hamartoma Tumor syndrome (PHTS). See our Other Considerations section for more information about these disorders.

The name stands for "Phosphatase and Tensin Homolog." The gene is located on chromosome 10. helps control cell division. 



Last updated March 17, 2022

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FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022