General information for people with inherited NBN mutations
Both men and women can carry an inherited mutation in the NBN gene.
People with an inherited mutation in NBN have an increased risk for certain cancers. See the Cancer Risk section for more information. There are guidelines for screening and prevention for certain cancers in people with an NBN mutation. There also may be clinical trials available for people who test positive for an NBN mutation. See our Risk Management section for more information about screening options in people with NBN mutations.
People diagnosed with an NBN mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information about clinical trials for people with an NBN mutation.
Inheriting an NBN mutation from both parents can cause Nijmegen breakage syndrome, a rare condition. See our Other Considerations section for more information about this disorder.
The name NBN stands for "Nibrin," a protein that is made by the NBN gene. The gene is located on chromosome 8. NBN is involved in DNA repair.
If you are a person with an NBN mutation, you can find peer support through the following resources:
- Register for the FORCE Message Boards to connect with others who share your situation. Once you register, you can post on the Share Your Mutation board to connect with other people who carry an NBN mutation.
- FORCE's Peer Navigation Program will match you with a volunteer who shares your mutation and situation and provide you with a free resource guide.
- Contact the FORCE impact leaders in your area to link to local support groups and other resources.
- Attend a virtual support meeting in your area.
- Read the stories from members of our community.
- FORCE's eXaming the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you.
- Genetics Home Reference is a site from the U.S. Library of Medicine that provides consumer-friendly information about the effects of an NBN mutation on human health.