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General information for people with inherited  mutations

Both men and women can carry an in the  gene. 

People with an in may have an increased risk for certain cancers. See the Cancer Risk section for more information. There are guidelines for screening and prevention for certain cancers in people with an mutation. There also may be clinical trials available for people who test positive for an mutation. See our Risk Management section for more information about screening options in people with mutations. 

People diagnosed with an mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information about clinical trials for people with an mutation.

Inheriting an mutation from both parents can cause Nijmegen breakage syndrome, a rare condition. See our Other Considerations section for more information about this disorder.

The name stands for "Nibrin," a protein that is made by the  gene. The  gene is located on chromosome 8. is involved in repair.

Last updated January 01, 2024

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FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022