Hereditary Cancer and Genetic Testing

General information for people with inherited NBN mutations

Both men and women can carry an inherited mutation in the NBN gene. 

People with an inherited mutation in NBN have an increased risk for certain cancers. See the Cancer Risk section for more information. There are guidelines for screening and prevention for certain cancers in people with an NBN mutation. There also may be clinical trials available for people who test positive for an NBN mutation. See our Risk Management section for more information about screening options in people with NBN mutations. 

People diagnosed with an NBN mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information about clinical trials for people with an NBN mutation.

Inheriting an NBN mutation from both parents can cause Nijmegen breakage syndrome, a rare condition. See our Other Considerations section for more information about this disorder.

The name NBN stands for "Nibrin," a protein that is made by the NBN gene. The  gene is located on chromosome 8. NBN is involved in DNA repair.


If you are a person with an NBN mutation, you can find peer support through the following resources: