General information for people with inherited mutations
Both men and women can carry an inherited mutation in the gene.
People with an inherited mutation in may have an increased risk for certain cancers. See the Cancer Risk section for more information. There are guidelines for screening and prevention for certain cancers in people with an mutation. There also may be clinical trials available for people who test positive for an mutation. See our Risk Management section for more information about screening options in people with mutations.
People diagnosed with an mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information about clinical trials for people with an mutation.
Inheriting an mutation from both parents can cause Nijmegen breakage syndrome, a rare condition. See our Other Considerations section for more information about this disorder.
The name stands for "Nibrin," a protein that is made by the gene. The gene is located on chromosome 8. is involved in repair.
Get Support
FORCE offers many peer support programs for people with inherited mutations.
- Our Message Boards allow people to connect with others who share their situation. Once registered, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Our Peer Navigation Program will match you with a volunteer who shares your mutation and situation.
- Our moderated, private Facebook group allows you to connect with other community members 24/7.
- Check out our virtual and in-person support meeting calendar.
- Join one of our Zoom community group meetings.
updated: 08/06/2022