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Keyword: brca

FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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Showing 81 through 90 out of 122

Relevance: Medium-Low

Strength of Science: Medium-Low

Research Timeline: Human Research

Study : No new high-risk breast cancer genes here

Most relevant for: People with a family history of breast cancer but no known inherited mutation

While some of the genes that cause hereditary breast cancer are known (for example, inherited mutations in genes like BRCA, ATM and PALB2), others remain unidentified. Two studies found 72 DNA changes (also known as “variants” or “SNPs”) that affect breast cancer risk. These variants are different from mutations in genes that dramatically increase cancer risk. Most of these new variants are located outside of the portion of DNA that is used to make proteins. Further research is needed on these new variants before they can be used by doctors to help people understand and manage their risk for cancer. (1/12/18)

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Relevance: High

Strength of Science: Medium-High

Study : Birth control and breast cancer risk among younger women

Most relevant for: Young women on, or considering taking hormonal birth control

On December 7, 2017 the New England Journal of Medicine published results from a study by Lina Mørrch of the University of Copenhagen and colleagues showing that hormonal contraceptives (birth control) increase the risk of breast cancer. The study is unique because it is one of the first to specifically assess the breast cancer risk associated with newer, low-dosage methods of contraception. The large and significant effort analyzed medical data of nearly 1.8 million young women in Denmark on average for over 10.9 years. Results were covered widely in the U.S. by many major media outlets, including the New York Times, USA Today, Forbes and Time.  (12/14/17)

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Relevance: Medium-High

Quality of Writing: Medium-High

Article : Can lifestyle changes impact breast cancer risk?

Most relevant for: Any woman concerned about her risk for breast cancer

A recent New York Times article shared how “adopting protective living habits”  could help keep breast cancer “at bay”.  While many of these lifestyle changes and strategies like not smoking, avoiding weight gain, reducing alcohol consumption, eating a heart-healthy diet, and increasing physical activity have been shown to reduce breast cancer risk, there are other risk factors that one cannot control such as having a BRCA or other mutation that significantly increases breast cancer risk. Importantly, no one strategy has been proven to totally eliminate breast cancer risk. However many of these approaches have overall health benefits. (9/21/2017)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Does expanded genetic testing benefit Jewish women diagnosed with breast cancer?

Most relevant for: Jewish women with breast cancer who previously tested negative for the three most common BRCA mutations

BRCA1 and BRCA2 mutations are common in people of Eastern European (Ashkenazi) Jewish descent. About 2% of all Ashkenazi Jewish people will test positive for one of three common mutations in these genes. Genetic testing for Jewish people sometimes focuses on only the three most common mutations. For Jewish women with breast cancer, little is known about their chance of carrying a different hereditary mutation that may increase risk. This study looked at expanded genetic testing in Jewish women diagnosed with breast cancer to learn how often they carried mutations other than the three most common BRCA gene mutations found in Ashkenazi Jewish people. (09/13/17)

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Relevance: High

Strength of Science: High

Research Timeline: Post Approval

Study : New cancer risk estimates for BRCA1/2 mutation carriers

Most relevant for: Women with an inherited mutation in BRCA1 or BRCA2

Cancer risk estimates for BRCA1 and BRCA2 mutation carriers are important because they impact patient decision-making. Until now, almost all risk estimates for mutation carriers were based on results of retrospective studies that looked back on mutation carriers who had cancer. This new study is prospective—it followed almost 10,000 BRCA mutation carriers without cancer to see if or when they developed breast or ovarian cancer. The cancer risk estimates of this study may be more accurate because it followed mutation carriers who did not have cancer over time. (7/28/17)

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Relevance: Medium-High

Strength of Science: Medium-High

Study : Gaps in genetic testing and decision-making for women with early-stage breast cancer

Most relevant for: People diagnosed with early stage breast cancer

Genetic testing for cancer risk is now more affordable and easier to obtain. As a result, many breast cancer patients are tested without ever seeing a genetic counselor. Genetic testing results affect treatment decision making, but they can be confusing, especially if patients do not receive genetic counseling. This study looks at breast cancer patients’ experiences following genetic testing and how testing results affect surgical decision making. (7/14/17)

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Relevance: Medium-High

Strength of Science: Medium-Low

4 April 2017

Study : Routine breast cancer screening leads to overdiagnosis

Most relevant for: Women at average risk for breast cancer

Routine breast cancer screening for women of average risk has been controversial for many years because some believe that the benefits do not outweigh the risks. Recent headlines covering a study in Denmark suggests that routine breast cancer screening leads to “overdiagnosis” of breast cancer. (4/4/17)

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Relevance: High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Patient experiences with genetic testing

Most relevant for: Women diagnosed with early-stage breast cancer

Patients can now find out if they have a mutation in more than 20 different genes that are associated with cancer risk, thanks to research advances and the decreasing cost of genetic testing. However, patients’ experiences and use of genetic counseling and testing with these changes are unknown. Do patients want genetic testing? Are they getting tested? (3/7/17)

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Relevance: Medium-High

Strength of Science: Medium

Research Timeline: Human Research

Study : Research suggests exercise is safe for breast cancer patients at risk for lymphedema

Most relevant for: People with, or at high risk for lymphedema after breast cancer

Patients and health care providers are often concerned about how exercise affects lymphedema (swelling in the arm or hand) in breast cancer survivors or other women who have had lymph node biopsy at the time of mastectomy. Research on this topic has been mixed. A new study suggests that exercise after breast cancer treatment does not lead to lymphedema or worsen existing lymphedema. However, because this study was small, more work needs to be done to understand the relationship between exercise and lymphedema in cancer survivors. (2/22/17)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : A step in the development of a new breast cancer risk assessment tool for Hispanic women

Most relevant for: Hispanic women

Current tools used to calculate breast cancer risk make their estimations based on data from non-Hispanic white women and may not accurately predict breast cancer risk in women of other races and ethnicities. With further testing, a new risk assessment tool developed specifically for Hispanic women could more accurately predict breast cancer risk in women who do not have mutations in BRCA or other genes associated with hereditary breast cancer. (02/07/17)

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