In portal: Breast Cancer, Categories Risk for Recurrence

Study : Healthy romantic relationships may decrease stress and inflammation for breast cancer survivors

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Most relevant for: Women with breast cancer who have romantic partners

Satisfying romantic relationships may improve outcomes for women with breast cancer. In a new study, women who were more satisfied with their romantic relationships experienced less stress and lower inflammation. This study suggests that decreasing stress may be beneficial for breast cancer survivors. (7/25/20)

Study : A new blood test may help predict early-stage breast cancer patients at highest risk for recurrence

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Most relevant for: People with early-stage breast cancer

Which patients are at risk for a relapse of early-stage breast cancer? Tests to predict recurrence would help find people who need more monitoring after treatment and provide a chance to find and treat them earlier. This study looked at whether a blood test for tumor DNA (called circulating tumor DNA or ctDNA) is useful for finding people with recurrence earlier than current clinical practice. (11/4/19)

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Personal Story : A “flu shot” against breast cancer? Not so fast

Relevance: Medium-Low

Research Timeline: Human Research

Most relevant for: Women diagnosed with Ductal Carcinoma In Situ (DCIS)

There have been multiple reports in the media of a Florida woman who had a "shot" to treat her DCIS with a promising outcome. This XRAY reviews the underlying story about this early breast cancer vaccine trial. (10/25/19)

Study : Is it safe for BRCA mutation carriers to become pregnant following breast cancer?

Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Most relevant for: Women with a BRCA mutation who are considering pregnancy after breast cancer

New research shows that pregnancy after breast cancer is safe for women with BRCA mutations and their babies. (9/4/19)

Study : New targeted therapy approved for early-stage HER2-positive breast cancer

Relevance: High

Strength of Science: High

Research Timeline: Post Approval

Most relevant for: People with early-stage, Her2-positive breast cancer (stages 1-3)

The KATHERINE trial looked at the benefit of the new drug, Kadcyla, for treating early-stage breast cancer after surgery and chemotherapy. The results of this study led to FDA approval in May 2019. (6/17/19)

Study : Declining use of chemotherapy for early-stage breast cancer: examining oncologist recommendations

Relevance: High

Strength of Science: Medium-High

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Most relevant for: People diagnosed with early stage breast cancer

A new study shows that chemotherapy use for early-stage, node-positive and node-negative breast cancers declined from 2013 to 2015. It also reports that oncologists’ recommendations are influenced to differing degrees by patient preferences and tumor test results, despite unchanging health care guidelines. (8/21/18)

Study : Some women with early-stage breast cancer forego chemotherapy

Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

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Most relevant for: People with node-negative, ER-positive breast cancer

A research study named the “Trial Assigning Individualized Options for Treatment” (TAILORx) asked whether chemotherapy is beneficial for women who have mid-range Oncotype DX tumor recurrence scores. This trial — the largest breast cancer treatment trial ever conducted— showed that endocrine therapy alone was as effective as endocrine therapy plus chemotherapy in women with certain types of early-stage breast cancer. The results of this trial are expected to be immediately practice changing (7/20/18)

Study : Metastasis is affected by wound healing and inflammation in study on mice

Relevance: Medium

Strength of Science: Medium-High

Research Timeline: Human Research

Most relevant for: Cancer patients who will be, or have recently undergone surgery

This study in mice looked at how wound healing after surgery affects metastasis. Researchers found that wound healing caused changes in the mouse immune system that allowed some cancer cells to grow, but that treatment with a non-steroidal anti-inflammatory drug (NSAID) reduced inflammation and frequency of metastases. While this research is promising, it remains to be seen if similar effects occur in humans. (5/17/18)

Study : Is asparagus linked to breast cancer metastasis?

Relevance: Low

Strength of Science: Medium

Research Timeline: Animal Studies

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Most relevant for: People diagnosed with breast cancer

A study published in the journal Nature shows that asparagine, a protein building block that takes its name from asparagus, promotes the spread of breast cancer in mice. The study by cancer experts from Britain, Canada and the U.S. investigated whether limiting the levels of asparagine in mice could reduce tumor metastasis. (3/2/18)

Study : Survival and mutation status in breast cancer patients under age 40

Relevance: Medium-High

Strength of Science: High

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Most relevant for: Young breast cancer patients

Studies have found conflicting rates of survival for BRCA mutation carriers who develop breast cancer, reporting better, worse and similar outcomes compared to patients with sporadic breast cancer. New results of the large Prospective Outcomes in Sporadic versus Hereditary (POSH) breast cancer study found no difference in survival rates between the two groups. The study also concluded that among young triple-negative breast cancer patients during the first 2 years after diagnosis, BRCA mutation carriers had an initial survival advantage compared to women without a BRCA mutation. (02/15/18)