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Risk Management & Treatment

Factors that affect  cancer risk

Every man is at risk for  cancer and the risk increases with age. A man in the general population has about a 12 percent lifetime risk of developing  cancer. This means that 12 out of every 100 men will get  cancer in their lifetime. 

African-American men have a higher lifetime risk for cancer and a higher risk for younger-onset cancer than men of other races and ethnicities.

Genes with inherited mutations linked to  cancer risk 

Inherited mutations in the genes listed below have also been linked to an increased risk for cancer. Note: the exact risk for some of the genes listed have not been well established. 

  • HOXB13

*Men with inherited mutations in and are more likely to develop prostate cancer than men without inherited mutations. 

** More research is needed to confirm a link between  cancer and an inherited mutation in this gene.

Last updated August 31, 2021

Find Experts
Find Experts

  • Ideally, experts recommend that men at high risk for cancer receive their screening from a high-risk specialty center. If you do not have access to a high-risk screening center, find out if your urologist regularly sees high-risk patients and if they are familiar with screening recommendations.
  • The Urology Care Foundation has a tool which allows you to search for urologists in your area. 
  • The National Cancer Institute (NCI)-designated comprehensive cancer centers deliver cutting-edge cancer care to patients in communities across the United States. Most centers have specialized screening and prevention centers for high risk people. Find a center near you and learn about its specific research capabilities, programs, and initiatives.
  • Register for the FORCE Message Boards to get referrals from other members. Once you register, you can post on the Find a Specialist board to connect with other people who share your situation.