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FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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Relevance: Medium-High

Article : Breast cancer risk for transgender men with inherited mutations

Most relevant for: Transgender men with an inherited mutation

There is little information related to the risks and treatment options for transgender men and nonbinary people who are at high-risk for breast cancer due to an inherited BRCA1 or BRCA2 mutation. We review an expert viewpoint on the implications of a BRCA mutation for transgender men undergoing breast removal as part of their gender-affirming care plan. (posted 5/19/22)

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Relevance: Medium

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Increasing melatonin use raises concerns

Most relevant for: people who take or consider taking melatonin to help with sleep.

Adult use of melatonin as a sleep aid has increased even though its benefits and risks are not well understood. This study looked at trends in melatonin use over the last 19 years. (Posted 4/14/2022)

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Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

Study : Quality of life for people with early-stage breast cancer who participated in the OlympiA clinical trial

Most relevant for: People with inherited mutations in BRCA1 or BRCA2 who have been diagnosed with early-stage, HER2-negative breast cancer.

The OlympiA study showed that the PARP inhibitor olaparib (Lynparza) is effective when used as maintenance therapy for people with an inherited BRCA1 or BRCA2 mutation who have early-stage breast cancer. Patient-reported outcomes from OlympiA suggest that olaparib was well tolerated and did not reduce quality of life or delay recovery from chemotherapy. (posted 2/22/22) Update: Based on OlympiA results, the FDA approved olaparib as adjuvant treatment for people with an inherited BRCA mutation who were diagnosed with early-stage HER2-negative breast cancer at high risk for recurrence. (03/11/2022)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

Study : Cannabis use among breast cancer patients

Most relevant for: People interested in using cannabis to relieve treatment side effects.

This study looked at patterns of cannabis use among breast cancer patients who are members of online health communities. Almost half of the study participants reported using cannabis to help manage treatment symptoms and side effects. The study also looked at reasons why patients used cannabis, where they obtained it and whether they perceived cannabis to be safe. While this study only looked at cannabis use among breast cancer patients it is likely results would be similar among patients diagnosed with other types of cancers. (posted 1/25/22)

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Relevance: High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Physical activity may prevent chemotherapy-related cognitive decline in women with breast cancer

Most relevant for: People concerned about the impact of chemotherapy

Many people experience chemo brain or chemo fog (cognitive effects) during and after chemotherapy. Researchers looked at the impact of physical activity on chemotherapy-related decline in memory, attention and information processing in women with breast cancer. This study shows that more physical activity before and during chemotherapy is linked to better information processing after chemotherapy. (Posted 1/6/22)

Este artículo está disponible en español.

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Relevance: Medium-High

Research Timeline: Post Approval

Update : Stronger guidance about breast implant safety

Most relevant for: People with or considering breast implants

The FDA issued new guidance for breast implants so that all people with breast implants have the appropriate information to understand and make decisions about their healthcare. Required features include box warning, patient decision checklist, guidelines for screening for implant ruptures and patient device cards. (posted 12/14/21)

Este artículo está disponible en español.

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Relevance: Medium

Strength of Science: Medium-High

Research Timeline: Human Research

Study : Multiple sclerosis may affect breast and colorectal cancer survival

Most relevant for: People with multiple sclerosis who are diagnosed with cancer

People with multiple sclerosis (MS) have lower overall survival after a breast or colorectal cancer diagnosis compared to people diagnosed with these cancers who do not have multiple sclerosis. Survival differed by cancer type. (posted 12/10/21)

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Relevance: Medium-High

Strength of Science: High

Research Timeline: Human Research

Study : Bone-protecting drugs cut the risks for fractures caused by metastatic prostate cancer treatments

Most relevant for: People with metastatic castration resistant prostate cancer

Skeletal problems, especially bone fractures, are common in patients with advanced prostate cancer. To prevent these, many guidelines recommend the use of bone-protecting agents during treatment. The importance of giving a bone-protecting agent when treating patients with metastatic castration-resistant prostate cancer and bone metastases was confirmed in early results of an ongoing phase III trial. (11/5/21)

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Relevance: High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Drinking coffee or tea may improve survival after breast cancer

Most relevant for: Women with breast cancer who drink coffee or tea.

In a study of 8,900 women with stage 1, 2 or 3 breast cancer, those who drank coffee survived longer after a breast cancer diagnosis than those who did not drink coffee. Both coffee and tea were linked to improved survival from any cause. Several factors were linked to greater coffee or tea consumption, so this finding must be taken with some caution. However, breast cancer survivors who are regular coffee or tea drinkers may find this research reassuring.  (posted 8/31/21)

Este artículo está disponible en español.

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Relevance: Medium-High

Quality of Writing: High

Article : Overview of pancreatic cancer treatment options

Most relevant for: People with pancreatic cancer

This review looks at current strategies for pancreatic cancer care and potential future therapies. (posted 7/28/21)

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