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Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. You can do a quick search to filter our featured studies by cancer type, study type or key word, or a more in-depth search through clinicaltrials.gov.

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Search Results: Prevention, Detection & Risk + Screening & Early Detection (21 results)

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PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease

Prevention
Screening study for people with a mutation linked to prostate cancer risk

PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease

The PATROL (Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease) study is for people at risk for prostate cancer because they carry one or more genes that are known or suspected to increase prostate cancer risk: BRCA2, HOXB13, ATM, BRCA1, MLH1, MSH2, MSH6, PALB2, PMS2, CHEK2, RAD51D, or TP53.

Clinicaltrials.gov identifier: NCT04472338
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Comparing Screening Methods for Detection of Early-Stage Gastric Cancer in People with a CHD1 Genetic Mutation

Prevention
Gastric cancer screening study for people with a CHD1 inherited mutation

Comparing Screening Methods for Detection of Early-Stage Gastric Cancer in People with a CHD1 Genetic Mutation

This study will compare a new technique of screening for a type of inherited gastric cancer known as diffuse hereditary gastric cancer (DHGC) to see if it can identify cancer better than the current recommended screening. 

Clinicaltrials.gov identifier: NCT04535414
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Men at High Genetic Risk for Prostate Cancer

Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or other mutation

Men at High Genetic Risk for Prostate Cancer

The National Institutes of Health has a clinical trial for men at high genetic risk for prostate cancer. This is trial is for men without prostate cancer, ages 30 to 75, who have tested positive for Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or FANC (FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, and FANCM). The trial involves screening MRI of the prostate every two years and biopsy of the prostate if the MRI is abnormal. There is no cost for travel or study-related tests. 

Clinicaltrials.gov identifier: NCT03805919
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Pancreatic Cancer Early Detection for People  at High Risk

Prevention
Registry and biobank for high risk people undergoing pancreatic cancer screening

Pancreatic Cancer Early Detection for People at High Risk

The study will collect clinical information, family history, and samples (blood, saliva or cheek swab) from people and families at risk for pancreatic cancer. Collecting this information and samples will create a resource to drive research necessary for early detection and prevention of pancreatic ductal adenocarcinoma (PDAC).

Clinicaltrials.gov identifier: NCT04970056
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Early Detection of Colorectal Cancer for People with Lynch Syndrome

Prevention
People with Lynch Syndrome at risk for colon cancer

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Precancerous Polyps in Lynch Syndrome Patients, CORAL Study

This study will colect blood and stool samples to detect colorectal cancer or precancerous polyps in people with Lynch syndrome.

Clinicaltrials.gov identifier: NCT05410977
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Study for Women at Increased Risk of Developing Breast Cancer

Prevention
This study will create a system to assess an individual’s risk of breast cancer

Study for Women at Increased Risk of Developing Breast Cancer

This study will create a system to assess an individual’s risk of breast cancer based on random sampling of normal breast tissue as well as determine new and help understand previously identified risk biomarkers.

Clinicaltrials.gov identifier: NCT00291096
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WISDOM Study

Prevention
Study to Determine if Breast Cancer Screening can be Made Better by Personalizing Each Woman’s Mammogram Schedule

The WISDOM Study: Women Informed to Screen Depending on Measures of Risk

The goal of the Wisdom Study is to determine if breast cancer screening can be made better by personalizing each woman’s mammogram schedule, compared to the current one-size-fits-all, annual approach. The Wisdom Study is designed to end the confusion about when to start and how often to have a mammogram. For more information, visit the WISDOM Study website

Clinicaltrials.gov identifier: NCT02620852
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Screening in Men at High Risk of Developing Prostate Cancer

Prevention
Screening using MRI for men at risk of developing prostate cancer

MRI Screening in Men at High Risk of Developing Prostate Cancer

This study will determine if prostate magnetic resonance imaging (MRI) will find prostate cancer in men at high risk of developing prostate cancer.

Clinicaltrials.gov identifier: NCT05608694
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Pancreatic Cancer Screening Study (CAPS5)

Prevention
Screening study for people at high risk for pancreatic cancer

Pancreatic Cancer Screening Study (CAPS5)

CAPS5 is a study looking at screening for early cancer in people with an elevated lifetime risk of developing pancreatic cancer. The goal is to study biomarkers derived from images and tissue samples (blood, pancreas fluid, duodenal fluid) for the early detection of pancreatic cancer and precancerous lesions.

 

Clinicaltrials.gov identifier: NCT02000089
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Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Prevention
People at high risk for prostate cancer due to an inherited mutation

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

This study will look at how enhanced prostate cancer screening using MRI will improve early detection rates and further understanding of how inherited mutations can lead to development of prostate cancer.

Clinicaltrials.gov identifier: NCT05129605
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Blood Markers of Early Pancreas Cancer

Prevention
Observational study for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk.

Blood Markers of Early Pancreas Cancer

The purpose of this study is to try to find markers of early pancreatic cancer for individuals at higher-than-average risk, expedite the diagnosis in individuals with symptoms, and substantially improve an individual's chance of surviving the disease.

Clinicaltrials.gov identifier: NCT03568630
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Helping Latinas Understand Their Risk for Breast Cancer and Get Breast Cancer Care

Prevention
Latinas with a high risk of breast cancer

Helping Latinas Understand Their Risk for Breast Cancer and Get Breast Cancer Care

This study will teach Latinas with a high risk of breast cancer about how diet, exercise, ethnicity, genetics and screening and prevention guidelines may impact their likelihood for developing breast cancer.

Clinicaltrials.gov identifier: NCT05483283
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Upright MRI for Prostate Cancer Screening

Prevention
Screening for prostate cancer using upright MRI

Upright MRI for Prostate Cancer Screening

This study will compare the effectiveness of an upright magnetic resonance imaging (MRI) compared to prostate specific antigen (PSA) and current MRI imaging for prostate cancer screening.

Clinicaltrials.gov identifier: NCT03474913
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Helping People With a Genetic Mutation in BRCA1, BRCA2 or Lynch Syndrome Talk to Their Family Members About Their Risk for Cancer and Find the Best Way to Get Family Members Tested

Prevention
People with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome who have relatives who have not been tested

IGNITE-TX - Identifying Individuals for Genetic Testing for Familial Cancer

The IGNITE-TX study is all about helping people with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome talk to their family members about their risk for cancer and find the best way to get family members tested.

Clinicaltrials.gov identifier: NCT05677048
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Developing a Test for the Detection of Ovarian Cancer

Prevention

Developing a Test for the Detection of Ovarian Cancer

The purpose of this study is to develop a test for early detection of ovarian cancer. Two patient populations are included in this study: women scheduled for surgery or testing for suspected but undiagnosed ovarian/fallopian tube cancer, and women with a BRCA1 or BRCA2 mutation who are scheduled for a risk-reducing salpingo-oophorectomy. The study will examine DNA from a washing of the uterus (womb) and proteins found in the blood to see if they can detect ovarian cancer.

Clinicaltrials.gov identifier: NCT04794322
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Screening for Pancreatic Cancer in Patients with an Inherited BRCA1, BRCA2, PALB2 or ATM Mutation

Prevention

Preliminary Evaluation of Screening for Pancreatic Cancer in Patients with an Inherited Genetic Risk Due to a BRCA1, BRCA2, PALB2 or ATM Mutation

Improved screening for pancreatic cancer in high-risk groups, such as people with an inherited BRCA1, BRCA2, ATM, or PALB2 mutation, may help find cancer early and improve survival rates. People enrolled in this study will undergo screening using endoscopic ultrasound or MRI of the abdomen.

Clinicaltrials.gov identifier: NCT02478892
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Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families

Prevention
Screening study for women with a BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, PMS2, MLH1, MSH2, MSH6, or EPCAM mutation

Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families: MicroRNA Detection Study (MiDE)

The goal of MiDe is to develop a clinical diagnostic test to detect early onset ovarian cancer, as currently, there are no good screening or early detection tests available. Participants can be expected to provide up to 4 tubes of blood every 6 months for up to 5 years. We can collect these samples through mobile phlebotomy all around the US. 

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Pancreatic Cancer Screening Study for High Risk People

Prevention

A Pancreatic Cancer Screening Study for High Risk Individuals

The purpose of this study is to screen and detect pancreatic cancer and precancer in people with either a strong family history of pancreatic cancer, or an inherited mutation associated with pancreatic cancer risk.

Magnetic Resonance Imaging (MRI) will be used to screen for early stage pancreatic cancer. Participants will also be asked to donate a blood sample at specific intervals for the creation of a blood bank necessary for the development of a blood-based screening test for pancreatic cancer. 

Clinicaltrials.gov identifier: NCT03250078
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Denosumab and Mammographic Density in Premenopausal Women With Dense Breasts (TRIDENT)

Prevention

RANKL Inhibition With Denosumab on Mammographic Density in Premenopausal Women With Dense Breasts (TRIDENT)

The purpose of this study is to evaluate if denosumab can reduce the breast density of premenopausal women who have dense breasts. Denosumab is an FDA-approved injectable medication that is used to treat osteoporosis and to prevent fractures in cancer patients with bone metastases. This study could help us identify novel ways to prevent breast cancer in younger women.

Clinicaltrials.gov identifier: NCT04067726
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Study for People with Unexpected Genetic Results

Prevention

Genomic Services Research Program Study for People with Unexpected Genetic Results

A new study is recruiting people who received unexpected genetic test results about their cancer risk after having genetic testing done for some other reason.

This is a study of people with "secondary results” from genetic testing. Secondary results are unexpected. They are not related to the reason the person had the genetic test but are shared because they may be very important to the person’s health. Most secondary results have to do with high risks for health problems that can be treated or prevented. Many of these results are related to cancer risk. If you think you have received a secondary result, you may be eligible to join this study.

Clinicaltrials.gov identifier: NCT02595957
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Pancreatic Cancer Early Detection

Prevention

Pancreatic Cancer Early Detection Program

This is a study looking at esophageal ultrasound and Magnetic Resonance Imaging (MRI) as a screening for pancreatic cancer in high risk individuals. 

Clinicaltrials.gov identifier: NCT02206360
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Additional Results on Clinicaltrials.gov Prevention, Detection & Risk + Screening & Early Detection
87 results
Clinical Trial Official Title
NCT04473833 Transvaginal Ultrasonography as a Screening Method for Ovarian Cancer
NCT05968157 MIRAI-MRI: Comparing Screening MRI for Patients at High Risk for Breast Cancer Identified by Mirai and Tyrer-Cuzick
NCT04336397 Stool DNA to Improve Colorectal Cancer Screening Among Alaska Native People
NCT06052202 A Smartphone-Based Intervention to Improve Colorectal Cancer Screening in African American Men
NCT05608694 MRI Screening in Men at High Risk of Developing Prostate Cancer
NCT05384535 Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort
NCT04748380 Shared Decision-making and Colorectal Cancer Screening
NCT05838417 Promoting Informed Choice for Breast Cancer Screening: A Longitudinal Study
NCT05929820 Impact of Protect Your Colon™ on CRC Screening
NCT03250078 A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals
NCT04877912 Accurate, Rapid and Inexpensive MRI Protocol for Breast Cancer Screening
NCT02478892 Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk
NCT05980182 Engaging Black Men in Colorectal Cancer Screening
NCT05665660 Developing and Evaluating Culturally Relevant Interventions to Improve Breast Cancer Screening
NCT03699995 MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma
NCT03937453 A Pancreatic Cancer Screening Study in Individuals With New-Onset or Deteriorating Diabetes Mellitus
NCT05694559 Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
NCT05625659 Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts
NCT05785780 Aim 3, Optimizing CRC Screening in Patients With Diabetes in Safety-net Primary Care Settings
NCT05298605 Faith in Action! A Church-Based Navigation Model to Increase Breast Cancer Screening in Korean Women
NCT06011434 Testing Conversation Aid in Practice
NCT05667532 The C-MERIT Screening Cohort: Contrast-enhanced Mammography for Breast Cancer Screening and Risk Assessment in Women With Dense Breasts
NCT05129605 Prostate Cancer Genetic Risk Evaluation and Screening Study
NCT04890054 Screening More Patients for Colorectal Cancer Through Adapting and Refining Targeted Evidence-Based Interventions in Rural Settings, SMARTER CRC
NCT03474913 Upright MRI for Prostate Cancer Screening
NCT03407417 A Patient-centered Intervention Using Technology to Reduce Colorectal Cancer Disparities in Primary Care
NCT06043661 Early Detection of Breast Cancer
NCT04030507 Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer
NCT04313114 The PRIME-CRC Trial to Promote CRC Screening in Rural Communities
NCT05419531 The Purpose of This Study is to Determine the Frequency of Colorectal Cancer in Male and Female Endurance Athletes Between the Ages of 35 and 50
NCT05765214 Impact of Colorectal Cancer and Nutrition Education Program Among Minority Patients With Type 2 Diabetes
NCT03640208 Educate, Assess Risk and Overcoming Barriers to Colorectal Screening Among African Americans
NCT06294886 Vaginal Fluid Collection for Detection of Endometrial Cancer
NCT05051631 BRAVE Strategy - Breast Cancer Risk Assessment -achieVing Equity
NCT05036096 Cone Beam Breast CT for Breast Cancer Screening
NCT04671498 Droplet-BC Screening Test for the Detection of Breast Cancer, the DROPLET-BC Study
NCT05841355 Empowering Latinas to Obtain Guideline Concordant Screenings
NCT04348123 Interventional Program Educates, Identifies + Overcomes Barriers to Complete Screening Mammography
NCT05524428 Eliminating Barriers to Colorectal Cancer Screening Using Rapid Cycle Testing: A Pilot Study
NCT04904757 Contrast-enhanced Spectral Mammography (CESM) Breast Cancer Screening
NCT05408260 A Study to Compare the Effectiveness of Two Types of Ultrasound Technologies in Women Who Have Had Breast Cancer
NCT03729115 A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer
NCT06122896 Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
NCT04854304 Abbreviate or FAST Breast MRI for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts
NCT04192071 Virtual Human Delivered Nutrition Module for Colorectal Cancer Prevention
NCT04582500 Virtual Colonoscopy Using Omnipaque as a Contrast Agent
NCT06112795 Exploring Cultural Acceptability of Community Breast Cancer Risk Assessment Among Hispanic Women in Maricopa County
NCT06294873 Stool Sample Collection Study
NCT05975736 Searching for Masses and Calcifications at the Same Time in Breast Cancer Screening
NCT06398639 Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer
NCT05853848 Mammogram Mail- and Phone-based Interventions
NCT05960188 Project 1: Self-Triage by 2D Full-field Digital Mammography or Synthetic Images
NCT06105749 Biennial CEM in Women With a Personal History of Breast Cancer
NCT05483283 Empowering Vulnerable and Resilient Latinas to Obtain Breast Cancer Care
NCT03623945 Autoantibodies in Breast Cancer Detection
NCT04705363 A Sociolinguistic-enabled Web Application to Develop Precision Health Intervention for African Americans
NCT05678322 Optimizing Timing of rhPSMA-7.3 (18F) for Assessing Site(s) of Recurrent Disease Following Radical Prostatectomy
NCT05903885 A Cross-sectional Partnership to Improve Prevention
NCT05362344 Colorectal Cancer Screening in Cystic Fibrosis
NCT06059963 A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation
NCT05754658 African Cancer Genome: GMD
NCT01035112 Magnetic Resonance Imaging of Breast Cancer
NCT03568630 Blood Markers of Early Pancreas Cancer
NCT05410977 Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients, CORAL Study
NCT06117241 Reducing Metabolic Dysregulation in Dyads
NCT03715959 Nipple Aspirate Fluid in Detecting Breast Cancer
NCT06151223 A Prospective Registry for Patients at High-Risk for Pancreatic Cancer
NCT05056818 Comparison of Synthetic Mammography Versus Full-Field Digital Mammography in Image Interpretation and Performance Metrics
NCT03558048 The Effect of IBD Flares on Serum PSA
NCT05188586 New Onset Diabetes Management for Earlier Detection of Pancreatic Cancer (NODMED)
NCT05471128 MRI Fusion Biopsy vs. Micro-Ultrasound Guided Biopsy
NCT04331535 The Genomic Medicine at VA Study
NCT06022887 Time-Restricted Eating and Mindfulness-Based Stress Reduction to Reduce the Risk of Early-Onset Colorectal Cancer
NCT02206360 Pancreatic Cancer Early Detection Program
NCT04825834 DNA Evaluation of Fragments for Early Interception - Lung Cancer Training Study (DELFI-L101 Study)
NCT03147430 Early Detection of Breast Cancer in Women With Suspicious Mammograms
NCT05611151 Real-time Computer-Aided Detection of Colonic Adenomas With NEC WISE VISION® Endoscopy
NCT00539162 Use of the CA 125 Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women
NCT00843375 Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas
NCT04967352 Predicting Chronic Pain Following Breast Surgery
NCT04792684 Collection of Samples USOPTIVAL Study
NCT06388967 Pancreatic Cancer Detection Consortium
NCT05732623 Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
NCT04973007 Comparison of Contrast Agents in Liver MR for the Detection of Hepatic Metastases
NCT06342440 Early Detection of Advanced Adenomas and Colorectal Cancer
NCT03789162 Blood and Stool Sample Collection in Subjects With a Diagnosis of Colorectal Cancer or Colorectal Lesion: Act Fast
NCT04815876 PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy 2

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