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Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. You can do a quick search to filter our featured studies by cancer type, study type or key word, or a more in-depth search through clinicaltrials.gov.

Search Results: Prevention, Detection & Risk + Screening & Early Detection (13 results)

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Men at High Genetic Risk for Prostate Cancer

Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or FANC (FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, and FANCM) mutation.

Men at High Genetic Risk for Prostate Cancer

The National Institutes of Health has a clinical trial for men at high genetic risk for prostate cancer. This is trial is for men without prostate cancer, ages 30 to 75, who have tested positive for Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or FANC (FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, and FANCM). The trial involves screening MRI of the prostate every two years and biopsy of the prostate if the MRI is abnormal. There is no cost for travel or study-related tests. 

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Pancreatic Cancer Screening Study(CAPS5)

Prevention
Screening study for people at high risk for pancreatic cancer

Pancreatic Cancer Screening Study(CAPS5)

CAP5 is a study looking at screening for early cancer in people with an elevated lifetime risk of developing pancreatic cancer. The goal is to study biomarkers derived from images and tissue samples (blood, pancreas fluid, duodenal fluid) for the early detection of pancreatic cancer and precancerous lesions.

 

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Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Prevention
People at high risk for prostate cancer due to an inherited mutation

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

This study will look at how enhanced prostate cancer screening using MRI will improve early detection rates and further understanding of how inherited mutations can lead to development of prostate cancer.

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Blood Markers of Early Pancreas Cancer

Prevention
Screening for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk.

Blood Markers of Early Pancreas Cancer

The purpose of this study is to try to find markers of early pancreatic cancer for screening for individuals at higher-than-average risk, expedite the diagnosis in individuals with symptoms, and substantially improve an individual's chance of surviving the disease.

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Developing a Test for the Detection of Ovarian Cancer

Prevention

Developing a Test for the Detection of Ovarian Cancer

The purpose of this study is to develop a test for early detection of ovarian cancer. Two patient populations are included in this study: women scheduled for surgery or testing for suspected but undiagnosed ovarian/fallopian tube cancer, and women with a BRCA1 or BRCA2 mutation who are scheduled for a risk-reducing salpingo-oophorectomy. The study will examine DNA from a washing of the uterus (womb) and proteins found in the blood to see if they can detect ovarian cancer.

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Screening for Pancreatic Cancer in Patients with an Inherited BRCA1, BRCA2, PALB2 or ATM Mutation

Prevention

Preliminary Evaluation of Screening for Pancreatic Cancer in Patients with an Inherited Genetic Risk Due to a BRCA1, BRCA2, PALB2 or ATM Mutation

Improved screening for pancreatic cancer in high-risk groups, such as people with an inherited BRCA1, BRCA2, ATM, or PALB2 mutation, may help find cancer early and improve survival rates. People enrolled in this study will undergo screening using endoscopic ultrasound or MRI of the abdomen.

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Research Study to Help Improve Family Communication About Inherited BRCA1 or BRCA2 Mutations

Prevention

Research Study to Help Improve Family Communication About Inherited Mutations

The Ohio State University and FORCE want to understand if a family communication guide for people with BRCA mutations is helpful and if it’s also useful to have a video that you can text or email to family members that explains your BRCA mutation. We are currently looking for people between the ages of 18-80 who have mutation in BRCA1 or BRCA2, have an active email address, and an internet capable device like a computer, tablet, or smartphone.  Participants will be asked to complete a total of 3 surveys.  Participants will be randomly assigned to either receive just the communication guide or the guide plus the sharable.  Each survey will take 10-15 minutes (the study could take up to 1.5 hours to complete depending on how much time you spend reviewing the study materials). 

You can get more information or ask to participate in the study by sending an email to: [email protected].

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Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families

Prevention
Screening study for women with a BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, PMS2, MLH1, MSH2, MSH6, or EPCAM mutation

Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families: MicroRNA Detection Study (MiDE)

The goal of MiDe is to develop a clinical diagnostic test to detect early onset ovarian cancer, as currently, there are no good screening or early detection tests available. Participants can be expected to provide up to 4 tubes of blood every 6 months for up to 5 years. We can collect these samples through mobile phlebotomy all around the US. 

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Pancreatic Cancer Screening Study for High Risk People

Prevention

A Pancreatic Cancer Screening Study for High Risk Individuals

The purpose of this study is to screen and detect pancreatic cancer and precancer in people with either a strong family history of pancreatic cancer, or an inherited mutation associated with pancreatic cancer risk.

Magnetic Resonance Imaging (MRI) will be used to screen for early stage pancreatic cancer. Participants will also be asked to donate a blood sample at specific intervals for the creation of a blood bank necessary for the development of a blood-based screening test for pancreatic cancer. 

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Denosumab and Mammographic Density in Premenopausal Women With Dense Breasts (TRIDENT)

Prevention

RANKL Inhibition With Denosumab on Mammographic Density in Premenopausal Women With Dense Breasts (TRIDENT)

The purpose of this study is to evaluate if denosumab can reduce the breast density of premenopausal women who have dense breasts. Denosumab is an FDA-approved injectable medication that is used to treat osteoporosis and to prevent fractures in cancer patients with bone metastases. This study could help us identify novel ways to prevent breast cancer in younger women.

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Study for People with Unexpected Genetic Results

Prevention

Genomic Services Research Program Study for People with Unexpected Genetic Results

A new study is recruiting people who received unexpected genetic test results about their cancer risk after having genetic testing done for some other reason.

This is a study of people with "secondary results” from genetic testing. Secondary results are unexpected. They are not related to the reason the person had the genetic test but are shared because they may be very important to the person’s health. Most secondary results have to do with high risks for health problems that can be treated or prevented. Many of these results are related to cancer risk. If you think you have received a secondary result, you may be eligible to join this study.

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Pancreatic Cancer Early Detection

Prevention

Pancreatic Cancer Early Detection Program

This is a study looking at esophageal ultrasound and Magnetic Resonance Imaging (MRI) as a screening for pancreatic cancer in high risk individuals. 

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WISDOM Study

Prevention

The WISDOM Study: Women Informed to Screen Depending on Measures of risk

The goal of the Wisdom Study is to determine if breast cancer screening can be made better by personalizing each woman’s mammogram schedule, compared to the current one-size-fits-all, annual approach. The Wisdom Study is designed to end the confusion about when to start and how often to have a mammogram. For more information, visit the WISDOM Study website

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Additional Results on Clinicaltrials.gov Prevention, Detection & Risk + Screening & Early Detection
80 results
Clinical Trial Official Title
NCT04473833 Transvaginal Ultrasonography as a Screening Method for Ovarian Cancer
NCT04848051 Implementing Fit Kit Colorectal Cancer (CRC) Screening in High Risk Populations
NCT04336397 Stool DNA to Improve Colorectal Cancer Screening Among Alaska Native People
NCT04427527 Accelerating Colorectal Cancer Screening Through Implementation Science in Appalachia
NCT04940442 Outreach and Choice in Colorectal Cancer Screening
NCT05376241 Promoting Informed Choice for Breast Cancer Screening
NCT05608694 MRI Screening in Men at High Risk of Developing Prostate Cancer
NCT05384535 Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort
NCT04748380 Shared Decision-making and Colorectal Cancer Screening
NCT04450264 Increasing African Immigrant Women's Participation in Breast Cancer Screening
NCT03250078 A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals
NCT04877912 Accurate, Rapid and Inexpensive MRI Protocol for Breast Cancer Screening
NCT02478892 Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk
NCT03699995 MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma
NCT03937453 A Pancreatic Cancer Screening Study in Individuals With New-Onset or Deteriorating Diabetes Mellitus
NCT05472064 Design of Chatbot Persona for Breast Cancer Screening Outreach Among Black Women
NCT05694559 Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
NCT05298605 Faith in Action! A Church-Based Navigation Model to Increase Breast Cancer Screening in Korean Women
NCT05667532 The C-MERIT Screening Cohort: Contrast-enhanced Mammography for Breast Cancer Screening and Risk Assessment in Women With Dense Breasts
NCT04890054 Screening More Patients for Colorectal Cancer Through Adapting and Refining Targeted Evidence-Based Interventions in Rural Settings, SMARTER CRC
NCT05129605 Prostate Cancer Genetic Risk Evaluation and Screening Study
NCT03407417 A Patient-centered Intervention Using Technology to Reduce Colorectal Cancer Disparities in Primary Care
NCT03474913 Upright MRI for Prostate Cancer Screening
NCT05055843 Novel Synthetic T2W MR Imaging and Spin Parameter Mapping Techniques for Screening Prostate Cancer
NCT04030507 Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer
NCT04313114 The PRIME-CRC Trial to Promote CRC Screening in Rural Communities
NCT05419531 The Purpose of This Study is to Determine the Frequency of Colorectal Cancer in Male and Female Endurance Athletes Between the Ages of 35 and 50
NCT04683744 Facilitators and Barriers to Cancer Screening: Stakeholder Perspectives on Implementation
NCT05631873 Colonoscopy Screening: Setting Epic Follow-up Times
NCT05650086 Novel Thermal Imaging Technique for Breast Screening
NCT03640208 Educate, Assess Risk and Overcoming Barriers to Colorectal Screening Among African Americans
NCT04683731 Helping Patients and Providers Make Better Decisions About Colorectal Cancer Screening
NCT05051631 BRAVE Strategy - Breast Cancer Risk Assessment -achieVing Equity
NCT04671498 Droplet-BC Screening Test for the Detection of Breast Cancer, the DROPLET-BC Study
NCT04348123 Interventional Program Educates, Identifies + Overcomes Barriers to Complete Screening Mammography
NCT04904757 Contrast-enhanced Spectral Mammography (CESM) Breast Cancer Screening
NCT05408260 A Study to Compare the Effectiveness of Two Types of Ultrasound Technologies in Women Who Have Had Breast Cancer
NCT04854304 Abbreviate or FAST Breast MRI for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts
NCT04582500 Virtual Colonoscopy Using Omnipaque as a Contrast Agent
NCT04414306 Screen to Save 2: Rural Cancer Screening Educational Intervention
NCT04662879 Early Detection Initiative for Pancreatic Cancer
NCT05257057 Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome
NCT04085510 Tomosynthesis vs. Contrast-Enhanced Mammography in Women With Personal History of Breast Cancer in Western Pennsylvania
NCT05551052 CRC Detection Reliable Assessment With Blood
NCT02470273 Diagnostic Imaging Study for the Melanoma Advanced Imaging Dermatoscope (mAID)
NCT04763824 KanSurvive: Testing a Model for Improving Cancer Survivorship Care in Rural Practice
NCT05483283 Empowering Vulnerable and Resilient Latinas to Obtain Breast Cancer Care
NCT03623945 Autoantibodies in Breast Cancer Detection
NCT04705363 A Sociolinguistic-enabled Web Application to Develop Precision Health Intervention for African Americans
NCT04086771 Southeast Asian Women's Health Project
NCT05127096 Sample Collection Study for the CellMax Life Circulating Tumor Cell and Circulating Tumor DNA Platforms for the Early Detection of Colorectal Cancer and Adenomas
NCT05362344 Colorectal Cancer Screening in Cystic Fibrosis
NCT05246839 Informed Choice - Compass
NCT01035112 Magnetic Resonance Imaging of Breast Cancer
NCT05410977 Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients, CORAL Study
NCT03568630 Blood Markers of Early Pancreas Cancer
NCT04259762 Enhancing Cancer Prevention and Control Pathways-Native Health Initiative
NCT05076266 COVID-19 Related Financial Hardship and Distress in Women Who Decline TMIST (EA1151) Participation
NCT04341129 Abbreviated MRI Protocol: Initial Experience With Dotarem® (Gadoterate Meglumine)
NCT03984695 Sexual Health Empowerment for Women's Health
NCT03715959 Nipple Aspirate Fluid in Detecting Breast Cancer
NCT05056818 Comparison of Synthetic Mammography Versus Full-Field Digital Mammography in Image Interpretation and Performance Metrics
NCT03218423 Longitudinal Performance of Epi proColon
NCT03558048 The Effect of IBD Flares on Serum PSA
NCT05188586 New Onset Diabetes Management for Earlier Detection of Pancreatic Cancer (NODMED)
NCT04331535 The Genomic Medicine at VA Study
NCT02206360 Pancreatic Cancer Early Detection Program
NCT04825834 DNA Evaluation of Fragments for Early Interception - Lung Cancer Training Study (DELFI-L101 Study)
NCT03147430 Early Detection of Breast Cancer in Women With Suspicious Mammograms
NCT04583072 Stockholm3 Validation Study in a Multi-Ethnic Cohort
NCT00539162 Use of the CA 125 Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women
NCT00579514 Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients
NCT00843375 Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas
NCT04967352 Predicting Chronic Pain Following Breast Surgery
NCT04792684 Collection of Samples USOPTIVAL Study
NCT04570722 Ipsilateral Peripheral Intravenous Access Procedures (The iPIVAP Study)
NCT04973007 Comparison of Contrast Agents in Liver MR for the Detection of Hepatic Metastases
NCT03789162 Blood and Stool Sample Collection in Subjects With a Diagnosis of Colorectal Cancer or Colorectal Lesion: Act Fast
NCT04843566 Evaluation of Transperineal Biopsy Under Local Anesthesia
NCT04815876 Transperineal vs. Transrectal MRI-targeted Prostate Biopsy

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