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Collecting Blood and Stool Samples to Detect Colorectal Cancer or Precancerous Polyps in Lynch Syndrome Patients (CORAL Study)

Prevention

People with Lynch Syndrome at risk for colon cancer

Clinicaltrials.gov identifier:
NCT05410977

Study Contact Information:

For additional information, please contact: the Clinical Trials Referral Office by phone 855-776-0015 or by email [email protected]

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Overview
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Details
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About the Study

This study will determine the effectiveness of a screening technique, multitarget stool testing, for the detection of colorectal cancer in individuals with . Multitarget stool testing uses stool samples to look for signs of colon cancer. This study will also create a collection of blood and stool samples from individuals with and early onset colorectal cancer (diagnosed younger than 50 years old). 

 

This Study is Open To:

Patients 18 years or older who have: 

  • A diagnosis of (mutation in , , , , or ) OR who have suspected OR who have been diagnosed with early onset colorectal cancer (diagnosed younger than 50 years old)
  • A colonoscopy OR flexible sigmoidoscopy scheduled 90 days before or after sample collection 

This Study is NOT Open To:

People who do not meet the inclusion criteria defined above and those who: 

  • Have had cancer in the 5 years before sample collection (not including some skin cancers) 
  • Have had chemotherapy for cancer treatment in the 5 years before sample collection 
  • Have had abdominal radiation before sample collection 
  • Have had therapy to remove or shrink a colorectal lesion before sample collection 
  • Have a diagnosis of non-Lynch hereditary colon cancer syndrome such as familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), (PJS), juvenile polyposis syndrome (JPS), , or POL

What the Study Involves

Patients will give blood and stool samples no more than 90 days before or between 7-90 days after their routine colonoscopy or flexible sigmoidoscopy (using a flexible tube with a video camera to examine the colon and rectum.). Patients will also give the researchers permission to look at their medical records.

Study Contact Information:

For additional information, please contact: the Clinical Trials Referral Office by phone 855-776-0015 or by email [email protected]

Locations:

Arizona

City: Scottsdale RECRUITING
Facility: Mayo Clinic in Arizona
Contact Info:
[email protected] 480-574-1346
[email protected] 855-776-0015
Jewel Samadder, M.D.

California

City: San Francisco RECRUITING
Facility: University of California San Francisco
Contact Info:
[email protected] 415-514-8087
Aparajita Singh,, MD

Colorado

City: Aurora RECRUITING
Facility: University of Colorado Anschutz Medical Center
Contact Info:
[email protected] 303-724-6070
Swati Patel, MD

Florida

City: Jacksonville RECRUITING
Facility: Mayo Clinic in Florida
Contact Info:
[email protected] 855-776-0015
Douglas L. Riegert-Johnson, MD

Massachusetts

City: Boston RECRUITING
Facility: Dana Farber Cancer Institute
Contact Info:
[email protected] 857-215-2924
Sapna Syngal, MD, MPH

Minnesota

City: Rochester RECRUITING
Facility: Mayo Clinic
Contact Info:
[email protected] 507-266-5755
[email protected] 855-776-0015
John Kisiel, M.D.

Pennsylvania

City: Philadelphia RECRUITING
Facility: University of Pennsylvania
Contact Info:
[email protected] 215-360-0833
Bryson Katona, MD, PhD

Washington

City: Seattle RECRUITING
Facility: University of Washington
Contact Info:
[email protected] 206-685-1179
William Grady, MD

Prevention

People with Lynch Syndrome at risk for colon cancer

Clinicaltrials.gov identifier:
NCT05410977

Study Contact Information:

For additional information, please contact: the Clinical Trials Referral Office by phone 855-776-0015 or by email [email protected]

PRINTER FRIENDLY PAGE