Clinicaltrials.gov identifier:
NCT05410977
Prevention
People with Lynch Syndrome at risk for colon cancer
Study Contact Information:
For additional information, please contact: the Clinical Trials Referral Office by phone 855-776-0015 or by email [email protected]
Collecting Blood and Stool Samples to Detect Colorectal Cancer or Precancerous Polyps in Lynch Syndrome Patients, CORAL Study
About the Study
This study will determine the effectiveness of a screening technique, multitarget stool testing, for the detection of colorectal cancer in individuals with . Multitarget stool testing uses stool samples to look for signs of colon cancer. This study will also create a collection of blood and stool samples from individuals with and early onset colorectal cancer (diagnosed younger than 50 years old).
What the Study Involves
Patients will give blood and stool samples no more than 90 days before or between 7-90 days after their routine colonoscopy or flexible sigmoidoscopy (using a flexible tube with a video camera to examine the colon and rectum.). Patients will also give the researchers permission to look at their medical records.
Study Sites
Arizona
Mayo Clinic in Arizona
Scottsdale, Arizona
Contact: Clinical Trials Referral Office 855-776-0015 [email protected]
Florida
Mayo Clinic in Florida
Jacksonville, Florida
Contact: Clinical Trials Referral Office 855-776-0015 [email protected]
Minnesota
Mayo Clinic
Rochester, Minnesota
Contact: Clinical Trials Referral Office 855-776-0015 [email protected]
Patients 18 years or older who have:
- A diagnosis of (mutation in , , , , or ) OR who have suspected OR who have been diagnosed with early onset colorectal cancer (diagnosed younger than 50 years old)
- A colonoscopy OR flexible sigmoidoscopy scheduled 90 days before or after sample collection
People who do not meet the inclusion criteria defined above and those who:
- Have had cancer in the 5 years before sample collection (not including some skin cancers)
- Have had chemotherapy for cancer treatment in the 5 years before sample collection
- Have had abdominal radiation before sample collection
- Have had therapy to remove or shrink a colorectal lesion before sample collection
- Have a diagnosis of non-Lynch hereditary colon cancer syndrome such as familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), (PJS), juvenile polyposis syndrome (JPS), , or POL