Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. Sign up for our community newsletter to stay up to date on the latest hereditary cancer research.
Featured Studies Results
Study Type: Prevention detection risk
Denosumab for Breast Cancer Risk Reduction in Women With an Inherited BRCA1 Mutation (The Breast Cancer Prevention Study)
Clinicaltrials.gov identifier:
NCT04711109
Prevention
Prevention study enrolling women ages 25-55 with a BRCA1 mutation
Pancreatic Cancer Screening Study (CAPS5)
Clinicaltrials.gov identifier:
NCT02000089
Prevention
Screening study for people at high risk for pancreatic cancer
A Study to Compare Two Surgical Procedures in Women with BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer (SOROCk)
Clinicaltrials.gov identifier:
NCT04251052
Prevention
Ovarian cancer prevention for women with a BRCA1 mutation who still have their ovaries
PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease
Clinicaltrials.gov identifier:
NCT04472338
Prevention
Screening study for people with a mutation linked to prostate cancer risk
The DETECT Study: Detecting Endometrial Cancer in Tampons
Clinicaltrials.gov identifier:
NCT03538665
Prevention
Early detection of endometrial cancer in women over 45 years of age who are undergoing hysterectomy surgery at the University of Alabama
Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05419011
Prevention
Testing a combination of vaccines for cancer prevention in Lynch syndrome
Screening Study for Men at High Genetic Risk for Prostate Cancer
Clinicaltrials.gov identifier:
NCT03805919
Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or other mutation
Testing the Safety And Action of the Investigational Drug REC-4881 in People With Familial Adenomatous Polyposis (FAP)
Clinicaltrials.gov identifier:
NCT05552755
Prevention
Prevention study for people with an APC mutation and FAP who have had colectomy surgery
Testing a Vaccine for Preventing or Treating Triple-Negative Breast Cancer
Clinicaltrials.gov identifier:
NCT04674306
Prevention
Prevention study for people with a BRCA1, BRCA2 or PALB2 inherited mutation who are planning to undergo risk-reducing mastectomy
Pancreatic Cancer Early Detection for People at High Risk
Clinicaltrials.gov identifier:
NCT04970056
Prevention
Registry and biobank for high risk people undergoing pancreatic cancer screening
Early Detection of Colorectal Cancer for People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05410977
Prevention
People with Lynch Syndrome at risk for colon cancer
WISDOM Study: Women Informed to Screen Depending on Measures of Risk
Clinicaltrials.gov identifier:
NCT02620852
Prevention
Study to determine if breast cancer screening can be made better by personalizing each woman’s mammogram schedule
Screening in Men at High Risk of Developing Prostate Cancer
Clinicaltrials.gov identifier:
NCT05608694
Prevention
Screening using MRI for men at risk of developing prostate cancer
My Best GI Eating Study
Clinicaltrials.gov identifier:
NCT05396846
Prevention
Diet and weight loss study for people who are overweight and at increased risk of colorectal cancer
Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy
Clinicaltrials.gov identifier:
NCT05287451
Prevention
Prevention study for women at high risk for ovarian cancer
Testing the Drug Obeticholic Acid for Familial Adenomatous Polyposis
Clinicaltrials.gov identifier:
NCT05223036
Prevention
Prevention study for people with an APC mutation and FAP or AFAP who have polyps in remaining tissue after colectomy surgery
Testing a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation
Clinicaltrials.gov identifier:
NCT04367675
Prevention
People with a BRCA1 or BRCA2 mutation
Studying the Use of Naproxen and Aspirin for Cancer Prevention in People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05411718
Prevention
Prevention study for people with Lynch syndrome
Restoring Sensation after DIEP Flap Reconstruction
Clinicaltrials.gov identifier:
NCT04533373
Prevention
Study for people undergoing DIEP flap reconstruction
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier:
NCT05129605
Prevention
People at high risk for prostate cancer due to an inherited mutation
Blood Markers of Early Pancreas Cancer
Clinicaltrials.gov identifier:
NCT03568630
Prevention
Observational study for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk
Helping Latinas Understand Their Risk for Breast Cancer and Get Breast Cancer Care
Clinicaltrials.gov identifier:
NCT05483283
Prevention
Latinas with a high risk of breast cancer
Upright MRI for Prostate Cancer Screening
Clinicaltrials.gov identifier:
NCT03474913
Prevention
Screening for prostate cancer using upright MRI
Helping People With a Genetic Mutation in BRCA1, BRCA2 or Lynch Syndrome Talk to Their Family Members About Their Risk for Cancer and Find the Best Way to Get Family Members Tested
Clinicaltrials.gov identifier:
NCT05677048
Prevention
People with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome who have relatives who have not been tested
Developing a Test for the Detection of Ovarian Cancer
Clinicaltrials.gov identifier:
NCT04794322
Prevention
Prevention study for women with a BRCA1 or BRCA2 mutation who are scheduled for risk-reducing salpingo-oophorectomy
Screening for Pancreatic Cancer in Patients with an Inherited BRCA1, BRCA2, PALB2 or ATM Mutation
Clinicaltrials.gov identifier:
NCT02478892
Prevention
Pancreatic cancer screening for people at high risk and with an inherited BRCA1, BRCA2, ATM, or PALB2 mutation
Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families
Prevention
Screening study for women with a BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, PMS2, MLH1, MSH2, MSH6, or EPCAM mutation
Blood Tests to Measure Ovarian Reserves in Women with a BRCA Mutation or Women Treated for Early-Stage Breast Cancer
Clinicaltrials.gov identifier:
NCT00823654
Prevention
Study for premenopausal women with early-stage breast cancer and high-risk women with BRCA mutations and no evidence of breast or ovarian cancer
Pancreatic Cancer Screening Study for High Risk People
Clinicaltrials.gov identifier:
NCT03250078
Prevention
Screening study to detect pancreatic cancer and precancer in people with either a strong family history of pancreatic cancer, or an inherited mutation associated with pancreatic cancer risk
Study for People with Unexpected Genetic Results
Clinicaltrials.gov identifier:
NCT02595957
Prevention
This study is recruiting people who received unexpected genetic test results about their cancer risk after having genetic testing done for some other reason
If you would like a more in-depth search, visit our In-Depth Search Tool that searches for studies in FORCE’s database and in clinicaltrials.gov