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Prevention

Prevention study for women at high risk for ovarian cancer

Clinicaltrials.gov identifier:
NCT05287451

Study Contact Information:

Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email:  rnitecki@mdanderson.org

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High-Risk Women (TUBA/WISP II)

Prevention

Prevention study for women at high risk for ovarian cancer

Clinicaltrials.gov identifier:
NCT05287451

Study Contact Information:

Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email:  rnitecki@mdanderson.org

PRINTER FRIENDLY PAGE
Glossary on
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About the Study

This study is looking at whether removal of the () followed by removal of the ovaries () at a later date closer to the time of natural menopause may reduce the risk of ovarian cancer nearly as much as removing both the ovaries and fallopian tubes at the same time (salpingo-oophorectomy) among women with an inherited , , , or mutation. Removing the fallopian tubes only first and the ovaries at a later time closer to natural menopause may lessen menopausal symptoms while still lowering the risk for ovarian cancer.

This Study is Open To:

Women are eligible if they:

Are premenopausal with a documented in one of the genes listed below. Eligible age depends on gene mutation. 

  • BRCA1: 25-40
  • BRCA2: 25-45
  • BRIP1: 30-50
  • RAD51C: 30-50
  • RAD51D: 30-50

Have at least one

Do not wish to be pregnant in the future 

This Study is NOT Open To:

Women cannot participate if they:

  • are post-menopausal (either naturally or due to cancer treatment)
  • wish for second removal of ovaries within 2 years of removing fallopian tubes
  • have a personal history of ovarian/fallopian tube or peritoneal cancer 
  • have had prior removal of the fallopian tubes (salpingectomy) 

What the Study Involves

Participants in this study will enroll in one of two groups. Participants will choose which group they enroll in based on their surgical preference. 

  • Group 1 will include women who choose risk-reducing removal of fallopian tubes (salpingectomy) with delayed oophorectomy. 
  • Group 2 will include women who choose removal of both fallopian tubes and ovaries at the same time, (salpingo-oophorectomy) which is considered standard-of-care.

Study Contact Information:

Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email:  rnitecki@mdanderson.org

Locations:

Massachusetts

City: Boston RECRUITING
Facility: Harvard Cancer Center
Contact Info:
cfeltmate@bwh.harvard.edu 617-732-8843
Colleen Feltmate, MD

Missouri

City: Saint Louis RECRUITING
Facility: Washington University School of Medicine
Contact Info:
hagemanna@wustl.edu 314-362-3181
Andrea Hagemann, MD

Texas

City: Houston RECRUITING
Facility: M D Anderson Cancer Center
Contact Info:
rnitecki@mdanderson.org 713-822-4502

Washington

City: Seattle RECRUITING
Facility: Fred Hutch/University of Washington/Seattle Children's Cancer Consortium
Contact Info:
bnorquis@uw.edu 206-598-8300
Barbara Norquist, MD