Prevention
Prevention study for women at high risk for ovarian cancer
Clinicaltrials.gov identifier:NCT05287451
Study Contact Information:
Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email: rnitecki@mdanderson.org
Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High-Risk Women (TUBA/WISP II)
Prevention
Prevention study for women at high risk for ovarian cancer
Clinicaltrials.gov identifier:NCT05287451
Study Contact Information:
Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email: rnitecki@mdanderson.org
About the Study
This study is looking at whether removal of the () followed by removal of the ovaries () at a later date closer to the time of natural menopause may reduce the risk of ovarian cancer nearly as much as removing both the ovaries and fallopian tubes at the same time (salpingo-oophorectomy) among women with an inherited , , , or mutation. Removing the fallopian tubes only first and the ovaries at a later time closer to natural menopause may lessen menopausal symptoms while still lowering the risk for ovarian cancer.
This Study is Open To:
Women are eligible if they:
Are premenopausal with a documented in one of the genes listed below. Eligible age depends on gene mutation.
- BRCA1: 25-40
- BRCA2: 25-45
- BRIP1: 30-50
- RAD51C: 30-50
- RAD51D: 30-50
Have at least one
Do not wish to be pregnant in the future
This Study is NOT Open To:
Women cannot participate if they:
- are post-menopausal (either naturally or due to cancer treatment)
- wish for second removal of ovaries within 2 years of removing fallopian tubes
- have a personal history of ovarian/fallopian tube or peritoneal cancer
- have had prior removal of the fallopian tubes (salpingectomy)
What the Study Involves
Participants in this study will enroll in one of two groups. Participants will choose which group they enroll in based on their surgical preference.
- Group 1 will include women who choose risk-reducing removal of fallopian tubes (salpingectomy) with delayed oophorectomy.
- Group 2 will include women who choose removal of both fallopian tubes and ovaries at the same time, (salpingo-oophorectomy) which is considered standard-of-care.
Study Contact Information:
Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email: rnitecki@mdanderson.org
Locations:
Massachusetts
City: Boston RECRUITING
Facility: Harvard Cancer Center
Contact Info:
cfeltmate@bwh.harvard.edu
617-732-8843
Colleen Feltmate, MD
Missouri
City: Saint Louis RECRUITING
Facility: Washington University School of Medicine
Contact Info:
hagemanna@wustl.edu
314-362-3181
Andrea Hagemann, MD
Texas
City: Houston RECRUITING
Facility: M D Anderson Cancer Center
Contact Info:
rnitecki@mdanderson.org
713-822-4502
Washington
City: Seattle RECRUITING
Facility: Fred Hutch/University of Washington/Seattle Children's Cancer Consortium
Contact Info:
bnorquis@uw.edu
206-598-8300
Barbara Norquist, MD