What are the signs of endometrial cancer?

All women should be educated on the possible signs of endometrial cancer and report any of the following to their doctor: unusual vaginal bleeding pelvic or abdominal pain bloating abdominal distension difficulty eating increased urinary frequency or urgency pain during sex Importantly, these symptoms do not mean you definitely have cancer, other conditions can cause the signs listed above.

How do they screen for endometrial cancer in high-risk women?

Expert guidelines include a list of screening options for people and increased risk for endometrial cancer. They emphasize that the research to date has not proven that these options lower the risk for dying of endometrial cancer. Screening for endometrial cancer in high-risk women may include a combination of the following: A pelvic exam involves the doctor carefully feeling the pelvic area for any changes that might be cancer. A transvaginal ultrasound uses sound waves to look for any thickening of the endometrial wall. This test works best for screening in post-menopausal women. Endometrial biopsies involve removing a small sample of endometrial tissue under local anesthesia. A pathologist will examine the tissue under a microscope and perform special tests to look for cancer or other abnormalities. Endometrial biopsies are quick outpatient procedures. a { text-decoration: none; color: #464feb; } tr th, tr td { border: 1px solid #e6e6e6; } tr th { background-color: #f5f5f5; } People at increased risk should discuss the benefits, limitations, and potential risks of each screening option with their doctor and promptly report any abnormal uterine bleeding or other symptoms.

Which genes are covered in the endometrial cancer screening guidelines?

The National Comprehensive Cancer Network (NCCN), is an organization of cancer experts that creates guidelines on prevention and treatment of cancer, including endometrial cancer. Recommendations for endometrial cancer risk management vary by gene. People with mutations in one of these genes should have a conversation with their healthcare professional about the benefits, limitations and costs of screening and other risk management options:

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Should every woman receive screening?

Currently, experts do not recommend screening healthy women at average risk for endometrial cancer. There are expert guidelines that outline options for screening for high-risk women that are outlined in the sections below.

Every woman should know the symptoms

often causes symptoms. For this reason, experts recommend that all women should be aware of the signs and symptoms of .

Endometrial cancer symptoms

Types of screening

Guidelines for high-risk women

Resources

What are the signs of ?

All women should be educated on the possible signs of and report any of the following to their doctor:

unusual vaginal bleeding
pelvic or abdominal pain
bloating
abdominal distension
difficulty eating
increased urinary frequency or urgency
pain during sex

Importantly, these symptoms do not mean you definitely have cancer, other conditions can cause the signs listed above.

How do they screen for in high-risk women?

Expert guidelines include a list of screening options for people and increased risk for . They emphasize that the research to date has not proven that these options lower the risk for dying of . Screening for in high-risk women may include a combination of the following:

A pelvic exam involves the doctor carefully feeling the pelvic area for any changes that might be cancer.
A transvaginal uses sound waves to look for any thickening of the endometrial wall. This test works best for screening in post-menopausal women.
Endometrial biopsies involve removing a small sample of endometrial tissue under local anesthesia. A pathologist will examine the tissue under a microscope and perform special tests to look for cancer or other abnormalities. Endometrial biopsies are quick outpatient procedures.

People at increased risk should discuss the benefits, limitations, and potential risks of each screening option with their doctor and promptly report any abnormal uterine bleeding or other symptoms.

Article : Six endometrial cancer survivor stories

Gynecologic Cancer Detection and Prevention

Which genes are covered in the screening guidelines?

The National Comprehensive Cancer Network (NCCN), is an organization of cancer experts that creates guidelines on prevention and treatment of cancer, including . Recommendations for risk management vary by gene. People with mutations in one of these genes should have a conversation with their healthcare professional about the benefits, limitations and costs of screening and other risk management options:

*
	NTHL1**	POLD1	POLE

Some mutations may not increase the risk for gynecologic cancers. If you have a mutation in your gene, it's important to speak with a cancer genetics expert to understand your risk for . *Requires a mutation in both copies of the gene.
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, Esophageal and Gastric; v1 2026.