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Medications to Reduce Risk
Review national guidelines for cancer screening and prevention; this information is listed by gene mutation and by cancer type.

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Medications to lower endometrial cancer risk

Medications may lower the risk for endometrial and other cancers in women at high risk due to an , but data is very limited. More research is needed to help experts understand how well these medications work, and which patients may benefit most from their use. High-risk women who are considering medications to lower their risk for endometrial cancer should speak with their doctor to decide whether is their best option for managing their risk.


Often used as birth control, progesterone has been shown to lower the risk for ovarian cancer in both high-risk women and average-risk women. Some small studies also suggest that progesterone can lower the risk for endometrial cancer in high-risk women. 

Progesterone may be given as a pill, injection or through an Intrauterine Device (IUD). Progesterone can have side effects which vary widely based on how the medication is taken.  These side effects may include an increased risk for breast cancer and blood clots and weight gain.  


In people with , daily aspirin may decrease the risk for colon cancer. Researchers are studying whether aspirin lowers the risk for other cancers, including endometrial cancer. Aspirin can increase the risk for bleeding.

Find Experts
Find Experts

The following resources can help you locate an expert near you.

Finding gynecologists with expertise in cancer risk and treatment

Related experts

Some symptoms and conditions related to female reproduction may be managed by other experts. 

Fertility experts

  • The Oncofertility Consortium maintains a national database of healthcare providers with expertise in fertility preservation and treatment of people who are diagnosed with cancer or have a high risk for cancer due to an .  
  • Livestrong has a listing of 450 sites that offer fertility preservation options for people diagnosed with cancer.
    Financial assistance may be available to make the cost of fertility preservation affordable for more patients. Patients are referred to those programs as needed.

Menopause experts

Sexual health experts

Other ways to find experts

  • The National Cancer Institute (NCI)-designated comprehensive cancer centers deliver cutting-edge cancer care to patients in communities across the United States. Most centers have specialized screening and prevention centers for high-risk people. Find a center near you and learn about its specific research capabilities, programs, and initiatives.
  • Register for the FORCE Message Boards to get referrals from other members. Once you register, you can post on the Find a Specialist board to connect with other people who share your situation.
Last updated May 23, 2020