Hereditary Cancer and Genetic Testing

Cancer treatment for people with CHEK2 mutations

People with an inherited CHEK2 mutation who have been diagnosed with cancer may have different treatment options than people without a mutation. To learn more about standard of care treatment options for specific types of cancer, visit our section on Cancer Treatment by Cancer Type

If you have an inherited CHEK2 mutation, have been diagnosed with cancer and any of the situations below apply to you, you may wish to speak to your doctor about your medical options. You may also consider enrolling in a clinical trial studying which treatments work best for people with an inherited CHEK2 mutation. 

Regardless of cancer type, people with a CHEK2 mutation may qualify for clinical trials looking for more effective treatments for cancer.

Surgical decisions for women diagnosed with breast cancer

Because of the increased risk for a second breast cancer diagnosis, women who are diagnosed with breast cancer who test positive for an inherited mutation in CHEK2 may choose bilateral mastectomy rather than lumpectomy and radiation. Mutation carriers who undergo mastectomy are less likely to develop a second breast cancer. 

PARP inhibitors

PARP inhibitors are a type of targeted therapy that work by blocking a protein used to repair damaged DNA. They were initially developed to treat cancers in people with an inherited BRCA1 or BRCA2 mutation. Since then, research and additional FDA approvals have expanded use of PARP inhibitors to more situations. People with an CHEK2 mutation who have been diagnosed with cancer may want to ask their doctor about PARP inhibitor therapy. 

Metastatic prostate cancer

The PARP inhibitor, Lynparza (olaparib) has received FDA-approval to treat men with metastatic, castration-resistent prostate cancer, who have a mutation in CHEK2 or another gene linked to a certain type of DNA damage repair. Lynparza may be used to treat men whose prostate cancer has progressed on enzalutamide (Xtandi) or abiraterone (Zytiga). 


If you are a person with a CHEK2 mutation, you can find peer support through the following resources:


The majority of public and private health insurance plans are required to cover cancer diagnosis and treatment; copays, coinsurance and deductibles often apply. Patient costs and coverage for specific doctors, facilities or treatments may vary based on your health plan. If your insurance company denies your claim, your health care provider can help you write an appeal letter, or you can use one of our sample appeal letters. Visit our section on Insurance and Paying for Care: Treatment for more information.


The following cancer treatment studies are open to people with a CHEK2 mutation. 

Breast cancer

Other cancers

Last updated September 03, 2021