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CHEK2 Gene Mutations

Learn about the cancer risks and prevention and treatment options for people with inherited CHEK2 mutations.

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Glossary on

Information for People with an Inherited Mutation

People with an in have increased risk for certain cancers, including:

  • breast cancer in women
  • male breast cancer
  • colorectal cancer

mutations have also been linked to an increased risk for and other cancers, but more research is needed to confirm this. 

People with a mutation have options for screening, prevention and treatment of . There are expert guidelines and clinical trials that focus on:

  • screening and early detection
  • risk-reduction
  • treatment 

Each of these topics is outlined in more detail in the sections highlighted below. 

In the News

New first-line treatment option for metastatic prostate cancer

Update: New first-line treatment option for metastatic prostate cancer

The FDA has approved Talzenna (talazoparib) with Xtandi (enzalutamide) as first-line treatments for some patients with metastatic castration-resistant prostate cancer....

More Information on Mutations

Cancer Risks

Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited mutations. 

More info

Risk Management Options

Read about expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients. 

More info

Cancer Treatment Options

Tumor testing and genetic testing can provide clues about which treatments may work best for your cancer. People with a mutation may have additional treatment or clinical trial options. 

More info

Watch Our Webinar for People with Mutations

Webinar: What's new for people with ATM, CHEK2 or PALB2 mutations?

Last updated June 29, 2024