Hereditary Cancer and Genetic Testing

Risk management for people with inherited CHEK2 mutations

The National Comprehensive Cancer Network (NCCN) provides risk management guidelines for men and women with CHEK2 mutations. We recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you determine the best risk-management plan. You can learn more about risk management options in our section on Screening and Risk Reduction by Cancer Type

Breast cancer screening and prevention

  • Annual mammogram (consider 3D mammography, if available) beginning at age 40 or 5-10 years younger than the earliest age of diagnosis in the family (but no later than age 40).
  • Consider annual breast MRI with contrast beginning at age 40 or 5-10 years younger than the earliest age of diagnosis in the family.
  • There is not enough evidence of benefit from risk-reducing mastectomy (RRM) for women with CHEK2 mutations. Experts recommend consideration of mastectomy be based on family history of breast cancer.
  • There are no current guidelines on breast cancer screening for men with a CHEK2 mutation. Men should speak with their doctor about the benefits and risks of screening. 

Colon cancer screening and prevention

  • Colonoscopy every 5 years beginning at age 40 (or 5-10 years earlier than the age of diagnosis of a close relative with colon cancer).

If you are a person with a CHEK2 mutation, you can find peer support through the following resources:


The following are screening and prevention studies open to people with a CHEK2 mutation. 

Prostate cancer

Visit our Research Search and Enroll Tool to find additional prevention and screening studies. 

Last updated September 03, 2021