Hereditary Cancer and Genetic Testing

Risk management for people with inherited  mutations

The National Comprehensive Cancer Network (NCCN) provides risk management guidelines for men and women with  mutations. We recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you determine the best risk-management plan. You can learn more about risk management options in our section on Screening and Risk Reduction by Cancer Type


Breast cancer screening and prevention

  • Annual  (consider 3D , if available) beginning at age 40 or 5-10 years younger than the earliest age of diagnosis in the family (but no later than age 40).
  • Consider annual breast with contrast beginning at age 40 or 5-10 years younger than the earliest age of diagnosis in the family.
  • There is not enough evidence of benefit from risk-reducing mastectomy (RRM) for women with mutations. Experts recommend consideration of mastectomy be based on family history of breast cancer.
  • There are no current guidelines on breast cancer screening for men with a mutation. Men should speak with their doctor about the benefits and risks of screening. 


Colon cancer screening and prevention

  • Colonoscopy every 5 years beginning at age 40 (or 5-10 years earlier than the age of diagnosis of a close relative with colon cancer).

find-support find-support

FORCE offers many peer support programs for people with inherited mutations. 

updated: 03/12/2022

paying-for-service paying-for-service

Health plan coverage of screening and prevention varies, and deductibles, coinsurance and copays often apply. If you need preventive services and your insurance company denies your claim, your health care provider can help you write an appeal letter, or you can use one of our sample appeal letters. Visit our section on Insurance and Paying for Care: Screening and Prevention for more information. 

updated: 01/23/2022

clinical-trials clinical-trials

The following are risk-management studies enrolling people with inherited mutations. Check study listings or contact the study team to see if you are eligible. 

Multiple cancers

cancer

  • NCT03805919: Men at High Genetic Risk for  Cancer. This is a  cancer screening study using  in high risk men. This study is open to men with , , , , , HOXB13, , , ,  and other inherited mutations.
  • NCT05129605: Cancer Genetic Risk Evaluation and Screening Study (PROGRESS).  This study will look at how well  MRI works as a screening tool for men at high risk for cancer. This study is open to men with inherited mutations in , , , , , , HOXB13, , , , , , , , , and other genes. 

Ovarian cancer

Pancreatic cancer

Additional risk-management clinical trials for people with inherited mutations may be found here.

updated: 03/14/2022

Last updated March 14, 2022