Hereditary Cancer


Relevance: Medium
Most relevant for: Women considering risk-reducing removal of both ovaries
Study: Early removal of ovaries may be linked to small increase in risk of Parkinson’s disease in later life
The lifetime risk of developing Parkinson’s disease is low. However, having surgery to remove both ovaries before natural menopause can slightly increase the risk of Parkinson's disease later in life. Researchers studied over 20 years of medical records, which confirmed this small increase in risk, particularly for women who have their ovaries removed before age 43. (Posted 5/3/23)
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Relevance: Medium-High
Most relevant for: Women with BRCA1 or BRCA2 mutations who are interested in reducing their ovarian cancer risk
Study: Hormonal birth control may reduce ovarian cancer risk in people with BRCA mutations
Hormonal birth control pill is linked to reduced ovarian cancer among people with an inherited BRCA mutation. Longer-acting forms of birth control given by implant, injection or as an intrauterine device may be associated with lower ovarian cancer risk for people with an inherited BRCA mutation. (Posted 4/28/23)
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Relevance: Medium
Most relevant for: People with an inherited mutation in BRCA1 or BRCA2 concerned about their breast cancer risk
Study: Weight may affect breast cancer risk in women with an inherited BRCA mutation
A study that looked at normal breast cells from women with an inherited BRCA mutation found more DNA damage among women who were overweight (based on a measurement known as body mass index) than those who were not overweight. The results suggest that maintaining a lower weight may reduce breast cancer among this high-risk population. (Posted 3/30/23)
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Relevance: Medium
Most relevant for: People interested in reducing cancer risk
Study: Increasing soy in your diet may lower your cancer risk
This study looked at a link between a diet rich in soy and cancer risk. With the addition of more recent literature, this study suggests that soy lowers the risk of cancer in the general population. (Posted 2/24/23)
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Relevance: Medium
Most relevant for: People with a BRCA1 or PALB2 mutation undergoing prophylactic bilateral mastectomy
Update: Breast cancer vaccine trial begins enrolling people with BRCA1 and PALB2 mutations
A new vaccine was first tested on people diagnosed with triple-negative breast cancer. The vaccine is now being tested to prevent breast cancer among people with an inherited mutation in BRCA1 or PALB2 who are at high risk and who are planning to have a risk-reducing mastectomy. (Posted 1/9/23) Este artículo está disponible en español.
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Relevance: High
Most relevant for: People with Lynch syndrome
Study: Prostate cancer screening may benefit people with Lynch syndrome
Initial results from the IMPACT trial show that PSA testing to screen for prostate cancer in people with Lynch syndrome can detect aggressive early prostate cancers. These findings support the use of PSA screening in men with Lynch syndrome, particularly men with an inherited mutation in an MSH2 or MSH6 gene. (Posted 11/10/22)
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Relevance: Medium-High
Most relevant for: People with Lynch syndrome and people with a personal and/or family history that suggests Lynch syndrome
Study: Resistant starch may help prevent some cancers in people with Lynch syndrome
This study looked at whether a type of nutrient known as resistant starch could lower the risk of cancers in people with Lynch Syndrome. Researchers found that resistant starch can reduce the risk of non-colorectal cancers but not colorectal cancer. (Posted 10/17/22)
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Relevance: Medium-High
Most relevant for: Mothers who have had genetic testing for BRCA1 or BRCA2 whether or not they have been diagnosed with breast or ovarian cancer
Study: Teens and young adults respond well to learning about familial cancer risk
Little is known about how awareness of hereditary cancer in a high-risk family affects the quality of life of teens and young adults. This study looked at the lifestyle choices, cancer awareness and quality of life of adolescents and young adults whose mothers had undergone testing for a BRCA mutation. (Posted 10/11/2022) Este artículo está disponible en español.
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Relevance: Medium
Most relevant for: People with breast implants
Update: FDA reports on new cancers linked to breast implants
New cancers have been found in women with both textured and smooth implants that are filled with either saline or silicone. These cancers are extremely rare. The FDA has reported cases of a type of skin cancer and blood cancers in the scar tissue that forms around breast implants. The newly reported lymphomas are different from the previously reported breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). (Posted 9/27/22). Este artículo está disponible en español.
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Relevance: High
Most relevant for: People at increased risk for pancreatic cancer because of family history or an inherited mutation.
Study: Screening for pancreatic cancer detects early-stage disease and improves survival
A research study has shown that screening for pancreatic cancer in people with an inherited mutation or family history was able to detect early-stage pancreatic cancers and improve survival. These results will likely change pancreatic cancer screening guidelines for high-risk individuals (Posted 8/30/22)
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