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Information for people with inherited  mutations

People with an in have an increased risk for certain cancers. See the Cancer Risk section for more information. There are guidelines for screening and prevention for certain cancers in people with a mutation. There also may be clinical trials available for people who test positive for a mutation. See our Risk Management section for more information about screening options in people with mutations. 

People diagnosed with a mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information about clinical trials for people with a mutation.

Inheriting a mutation from both parents can cause Fanconi anemia. See our Other Considerations section for more information about this disorder.

More about the gene

The name stands for "Partner and Localizer of ." The gene is located on chromosome 16. works together with  to repair damaged .

Last updated January 01, 2024

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Get Support

FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022