Hereditary Cancer and Genetic Testing

General information for people with inherited CDKN2A mutations

Both men and women can carry a mutation in the CDKN2A gene. The gene makes more than one protein and inherited mutations in the gene are named according to the protein affected by the mutation.

  • Mutations in CDKN2A (p16INK4a) is associated with a syndrome sometimes called Familial Atypical Mole/ Multiple Melanoma (FAMMM) + Pancreatic Cancer.
  • Mutations in CDKN2A (p14ARF) can increase the risk for melanoma. 

People with an inherited mutation in CDKN2A have increased risk for certain cancers. See the Cancer Risk section for more information. 

There are guidelines for cancer screening and prevention in people with an CDKN2A mutation. There also may be clinical trials available for people with an inherited CDKN2A mutation. See our Risk Management section for more information about screening options in people with CDKN2A mutations.

People with an inherited CDKN2A mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information about clinical trials for people with a CDKN2A mutation.

The name CDKN2A stands for "Cyclin-Dependent Kinase Inhibitor 2A." The gene provides instructions for making several tumor suppressor proteins. The CDKN2A gene is located on chromosome 9.

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If you are a person with a CDKN2A mutation, you can find peer support through the following resources:

Other organizations that provide support for people diagnosed with melanoma include:

  • AIM at Melanoma is a nonprofit organization that has online support and a list of in-person support groups by region. 

Other organizations that provide support for people diagnosed with pancreatic cancer include:

  • PanCAN is a nonprofit organization for people diagnosed with pancreatic cancer. 
  • Let's Win PC is a nonprofit organization that enables doctors, scientists, and patients to share fast-breaking information on potentially life-saving pancreatic cancer treatments and clinical trials.