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Cancer Treatment > By Cancer Type > Melanoma > Biomarkers, targeted and immunotherapies

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Stages and subtypes
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Standard therapy
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Biomarkers, targeted and immunotherapies
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Inherited mutations

Biomarkers, targeted and immunotherapies for melanoma

This section covers the following topics:


helps the body’s immune system to fight cancer. Two types of immunotherapies are commonly used to treat advanced melanoma: 

  • Immune checkpoint inhibitors are a type of  used to treat melanoma. These include:
    • Keytruda (pembrolizumab)
    • Opdivo (nivolumab)
    • Yervoy (ipilumumab)
      • Sometimes Yervoy is used in combination with Opdivo
  • Imlygic (talimogene laherparepvec or T-VEC therapy) is a genetically engineered virus that is used to treat advanced melanoma. The medication is injected directly into the tumor to stimulate an immune response.  


testing for treatment selection

tests look at samples of blood, tumor or other tissue for changes or abnormalities caused by cancer. These tests can give doctors clues about the cancer, including:

  • how fast the cancer is growing
  • which treatments are most likely to work
  • whether or not the cancer is responding to treatment or growing
  • whether or not the cancer has come back after remission

tests may be used to select treatments, and help patients avoid side effects from treatments that will not work for them. tests used to select a specific treatment are sometimes called companion diagnostic tests. These tests may be done on tumor tissue or on blood. See our Testing section for more information. 

Experts recommend that patients with advanced or recurrent melanoma also be tested for the following biomarkers:

  • Tumor testing can find a specific mutation in a gene known as BRAF.  In melanoma, the most common BRAF mutation is called V600E (may also be V600K/R/M/D/G).  Patients with a BRAF V600 mutation may benefit from the addition of targeted therapies known as BRAF inhibitors.

Additional tests that may be used for melanoma:

  • Tumor testing can find mutations in genes known as KIT and NRAS.
  • testing may help identify people who are eligible for certain clinical trials.


Target therapies for melanoma include:

  • BRAF inhibitors
    • BRAF inhibitors are oral medications that help slow down tumor growth in patients with advanced or recurrent melanoma that test positive for the tumor called a BRAF V600 mutation.
    • About half of all melanomas have a tumor mutation in the BRAF gene.
    • If your melanoma has a BRAF mutation often you will get both a BRAF inhibitor and a MEK inhibitor. Combining these drugs often works better than either one alone.
    • BRAF inhibitors include:
      • Tafinlar (dabrafenib)
      • Braftovi (encorafenib)
      • Zelboraf (vemurafenib)
  • MEK inhibitors
    • MEK inhibitors are oral medications that are given alone or in combination with a BRAF inhibitor to treat melanoma in people with a BRAF V600 mutation.
    • MEK inhibitors include:
      • Mekinist (trametinib)
      • Cotellic (cobimetinib)
      • Mektovi (binimetinib)


Table of targeted and immunotherapies for melanoma

Name of drug Type of agent Cancer Indication
Braftovi
(encorafenib)		 BRAF inhibitor (type of kinase inhibitor) Unresectable or melanoma

Combined with Mektovi (binimetinib), for the treatment of patients with unresectable or melanoma

 BRAF V600E or V600K tumor mutation
Cotellic
(cobimetinib)		 BRAF inhibitor (type of kinase inhibitor) Unresectable or melanoma Combined with Zelboraf (vemurafenib) for the treatment of patients with unresectable or melanoma  BRAF V600E or V600K tumor mutation
Mekinist (trametinib) MEK inhibitor
(type of kinase inhibitor)		 Melanoma Combined with Taflinar (dabrafenib) as treatment of patients with melanoma and involvement of lymph node(s), following complete resection BRAF V600E or V600K tumor mutation
Mekinist (trametinib) MEK inhibitor
(type of kinase inhibitor)		 Unresectable or melanoma As a single agent and in combination with dabrafenib for the treatment of unresectable or melanoma  BRAF V600E or V600K tumor mutation
Mektovi (binimetinib MEK inhibitor
(type of kinase inhibitor)		 Unresectable or melanoma Combined with Braftovi (encorafenib), for the treatment of patients with unresectable or melanoma  BRAF V600E or V600K tumor mutation
Tafinlar
(dabrafenib)		 BRAF inhibitor (type of kinase inhibitor) Unresectable or melanoma Combined with Mekinist (trametinib) for the treatment of patients with unresectable or melanoma  BRAF V600E or V600K tumor mutation
Tafinlar
(dabrafenib		 BRAF inhibitor (type of kinase inhibitor) Unresectable or melanoma Combined with Mekinist (trametinib) for the treatment of patients with unresectable or melanoma  BRAF V600E or V600K tumor mutation
Tafinlar
(dabrafenib		 BRAF inhibitor (type of kinase inhibitor) Melanoma Combined with Mekinist (trametinib) as treatment of patients with melanoma and involvement of lymph node(s), following complete resection BRAF V600E or V600K tumor mutation
Keytruda (pembrolizumab) Immune checkpoint inhibitor or unresectable melanoma For the treatment of patients with melanoma No required
Keytruda (pembrolizumab) Immune checkpoint inhibitor Melanoma For the treatment of patients with involvement of lymph node(s) following complete resection No required
Opdivo 
(nivolumab) 		 Immune checkpoint inhibitor or unresectable melanoma As a single agent or combined with ipilimumab No required
Opdivo 
(nivolumab)		 Immune checkpoint inhibitor or lymph node positive melanoma For the treatment of patients following complete resection No required
Yervoy (ipilumumab) Immune checkpoint inhibitor or unresectable melanoma For the treatment of patients with melanoma No required
Yervoy (ipilumumab) Immune checkpoint inhibitor Melanoma treatment of patients with cutaneous melanoma with pathologic involvement of regional of more than 1 mm who have undergone complete resection, including total lymphadenectomy No required
Imlygic (T-VEC or talimogene laherparepvec) Cancer vaccine Unresectable recurrent melanoma For local treatment of cutaneous, subcutaneous, and nodal lesions in patients with melanoma recurrent after initial surgery No required

paying-for-service paying-for-service

The majority of public and private health insurance plans are required to cover cancer diagnosis and treatment; copays, coinsurance and deductibles often apply. Patient costs and coverage for specific doctors, facilities or treatments may vary based on your health plan. Visit our section on Insurance and Paying for Care: Treatment  for more information, links to sample appeal letters and other resources. 

Some pharmaceutical companies and laboratories have assistance programs that help cover the cost for their medications, tumor testing or genetic testing for an inherited mutation: 

Organizations that offer co-pay assistance:

Other resources:

  • The American Cancer Society provides information and resources on covering the cost of cancer care. Public assistance, such as Medicaid may be available if you are ineligible for other programs. 
  • Needy Meds: Assistance programs to help patients with cost of medications and other healthcare.
  • Triage Cancer offers tools and resources to help individuals cope with the financial aspects of a cancer diagnosis.