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Targeted and Immunotherapies

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Targeted and Immunotherapies for Melanoma

This section covers the following topics:

helps the body’s immune system to fight cancer. Two types of immunotherapies are commonly used to treat advanced melanoma: 

  • Immune checkpoint inhibitors are a type of  used to treat melanoma. These include:
    • Keytruda (pembrolizumab)
    • Opdivo (nivolumab)
    • Tecentriq (atezolizumab)
    • Yervoy (ipilumumab)
  • Imlygic (talimogene laherparepvec or T-VEC therapy) is a genetically engineered virus that is used to treat advanced melanoma. The medication is injected directly into the tumor to stimulate an immune response.  

Targeted therapies for melanoma include:

  • BRAF inhibitors
    • BRAF inhibitors are oral medications that help slow down tumor growth in patients with advanced or recurrent melanoma that test positive for the tumor called a BRAF V600 mutation.
    • About half of all melanomas have a tumor mutation in the BRAF gene.
    • If your melanoma has a BRAF mutation often you will be treated with both a BRAF inhibitor and a MEK inhibitor. Combining these drugs often works better than either one alone.
    • BRAF inhibitors include:
      • Tafinlar (dabrafenib)
      • Braftovi (encorafenib)
      • Zelboraf (vemurafenib)
  • MEK inhibitors
    • MEK inhibitors are oral medications that are given alone or in combination with a BRAF inhibitor to treat melanoma in people with a BRAF V600 mutation.
    • MEK inhibitors include:
      • Mekinist (trametinib)
      • Cotellic (cobimetinib)
      • Mektovi (binimetinib)

Table of targeted and immunotherapies for melanoma

Name of drug Type of agent Cancer Indication
Braftovi
(encorafenib)
BRAF inhibitor (type of kinase inhibitor) Unresectable or melanoma

Combined with Mektovi (binimetinib), for the treatment of people with unresectable or melanoma

BRAF V600E or V600K tumor mutation
Cotellic
(cobimetinib)
BRAF inhibitor (type of kinase inhibitor) Unresectable or melanoma Combined with Zelboraf (vemurafenib) for the treatment of people with unresectable or melanoma  BRAF V600E or V600K tumor mutation
Mekinist (trametinib) MEK inhibitor
(type of kinase inhibitor)
Melanoma Combined with Taflinar (dabrafenib) as treatment of people with melanoma and involvement of lymph node(s), following complete resection BRAF V600E or V600K tumor mutation
Mekinist (trametinib) MEK inhibitor
(type of kinase inhibitor)
Unresectable or melanoma As a single agent and in combination with dabrafenib for the treatment of unresectable or melanoma  BRAF V600E or V600K tumor mutation
Mektovi (binimetinib MEK inhibitor
(type of kinase inhibitor)
Unresectable or melanoma Combined with Braftovi (encorafenib), for the treatment of people with unresectable or melanoma  BRAF V600E or V600K tumor mutation
Tafinlar
(dabrafenib)
BRAF inhibitor (type of kinase inhibitor) Unresectable or melanoma Combined with Mekinist (trametinib) for the treatment of people with unresectable or melanoma  BRAF V600E or V600K tumor mutation
Tafinlar
(dabrafenib)
BRAF inhibitor (type of kinase inhibitor) Unresectable or melanoma Combined with Mekinist (trametinib) for the treatment of people with unresectable or melanoma  BRAF V600E or V600K tumor mutation
Tafinlar
(dabrafenib)
BRAF inhibitor (type of kinase inhibitor) Melanoma Combined with Mekinist (trametinib) as treatment of people with melanoma and involvement of lymph node(s), following complete resection BRAF V600E or V600K tumor mutation

 

Zelboraf
(vemurafenib)

BRAF inhibitor (type of kinase inhibitor) Unresectable or melanoma Combined with Tecentriq (atezolizumab) and Cotellic (cobimetinib) in people with melanoma that has the BRAF gene mutation, when the cancer can’t be removed by surgery or has spread to other parts of the body. BRAF V600 mutations
Tecentriq
(atezolizumab)
Immune checkpoint inhibitor or unresectable melanoma

 

Combined with Cotellic (cobimetinib) and vemurafenib in people with melanoma that has the BRAF gene mutation, when the cancer can’t be removed by surgery or has spread to other parts of the body.

BRAF V600 mutations
Keytruda (pembrolizumab) Immune checkpoint inhibitor or unresectable melanoma For the treatment of people with melanoma No required
Keytruda (pembrolizumab) Immune checkpoint inhibitor Melanoma For the treatment of people with involvement of lymph node(s) following complete removal of the cancer No required
Opdivo 
(nivolumab) 
Immune checkpoint inhibitor or unresectable melanoma As a single agent or combined with ipilimumab No required
Opdivo 
(nivolumab)
Immune checkpoint inhibitor or lymph node positive melanoma For the treatment of people with following complete removal of the cancer No required
Yervoy (ipilumumab) Immune checkpoint inhibitor or unresectable melanoma For the treatment of people with melanoma No required
Yervoy (ipilumumab) Immune checkpoint inhibitor Melanoma treatment of people with cutaneous melanoma with spread to regional of more than 1 mm who have undergone complete removal of the cancer and No required
Imlygic (T-VEC or talimogene laherparepvec) Cancer vaccine Unresectable recurrent melanoma For local treatment of cutaneous, subcutaneous, and lymph node lesions in people with melanoma that came back after initial surgery No required

Paying For Care
Paying For Care

Paying for testing

Insurance companies are required to cover the costs for cancer treatment. Health plans may vary on the amount of out-of-pocket costs and coverage for specific doctors, facilities, tests or treatments. Your doctor's office and treating hospital should disclose how much your treatment may cost you and work with you on a plan to cover the cost of your care.

Medicare will cover the cost for genetic testing and testing for people who meet certain criteria. Medicare coverage varies based on where you live. Visit this site to find and contact your regional Medicare provider for more information about coverage. The Medicaid website has a link to state Medicaid programs, which list specific eligibility for each state.

If you need information about finding an insurance plan, watch our video: Choosing Wisely: How to Pick Insurance Plans.Visit our Health Insurance Appeals page for additional information on insurance appeals. 

Some laboratories have assistance programs that help cover the cost for tumor testing: 

Organizations that offer co-pay assistance:

Other resources:

  • The American Cancer Society provides information and resources on covering the cost of cancer care. Public assistance, such as Medicaid may be available if you are ineligible for other programs. 
  • Triage Cancer offers tools and resources to help individuals cope with the financial aspects of a cancer diagnosis.
Last updated February 14, 2024