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TP53 Gene Mutations (Li-Fraumeni Syndrome)

Learn about the cancer risks and medical options for people with inherited TP53 mutations.

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Glossary on

Information for People with Inherited Mutations ()

mutations cause a condition known as . People with an in have a very high lifetime risk for different types of cancers, including:

  • brain cancer
  • breast cancer
  • colorectal cancer
  • pancreatic cancer
  • sarcomas
  • other cancers

The risks for cancer begin at a very young age.

There are expert guidelines with recommendations for screening and prevention of these cancers. 

There may be family planning considerations and options for people with an inherited mutation. 

Each of these topics is outlined in more detail in the sections highlighted below. 

More Information on Mutations

Cancer Risks

Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited mutations. 

More info

Risk Management Options

Read about the latest expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients.   

More info

Cancer Treatment Options

People with a mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. 

More info

Other Considerations

People with mutations can develop cancer beginning at an early age. Learn about other important considerations for people with inherited mutations. 

More info

More Resources

Participate in Research

The studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool

Last updated February 25, 2024